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Modified water-based material as well as preparation method and application thereof

A water-based material and modification technology, applied in the field of materials, can solve the problems of changing the mechanical properties of contact lenses, long drug loading time, and fast drug release, and achieve the effects of controllable release, low cost, and excellent biocompatibility.

Pending Publication Date: 2022-07-08
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are some methods for preparing therapeutic contact lenses, such as simply soaking the contact lens in the drug solution, embedding drug-loaded colloidal nanoparticles or molecular imprinting in the contact lens, these methods have the disadvantages of long drug loading time and high drug loading capacity. Low, fast drug release and other limitations, most importantly, may change the mechanical properties of contact lenses, and mechanical properties are important parameters in the actual use of contact lenses

Method used

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  • Modified water-based material as well as preparation method and application thereof
  • Modified water-based material as well as preparation method and application thereof
  • Modified water-based material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Add 0.1433g of tris(2-carboxyethyl)phosphine to 10mL of ultrapure water, adjust the pH to 7.0 with NaOH; add 70mg of human lactoferrin to 10mL of ultrapure water to prepare 7mg / mL of human lactoferrin the aqueous solution;

[0058] Mix 200 μL of 50 mmol / L tris(2-carboxyethyl) phosphine aqueous solution with 200 μL of 7 mg / mL aqueous solution of human lactoferrin and add dropwise to a 18mm*18mm glass slide. After standing at room temperature for 2 hours, the surface of the mixed solution The formed transparent protein film self-floats on the aqueous solution (e.g. figure 1 shown), and then use the water-saturated agarose hydrogel to approach and contact the surface of the protein nanofilm to complete the adhesion (such as figure 2 shown).

Embodiment 2

[0060] Because protein nanofilms are optically transparent, in order to make the process of nanofilm-modified hydrogels more intuitive, the self-floating protein nanofilms were transferred into a 0.1 wt% Congo red aqueous solution, stained for 3 minutes at room temperature, and then transferred to ultrapure water Rinse off the float. Then transfer to ultrapure water and modify the agarose hydrogel (as image 3 shown).

Embodiment 3

[0062] The nanofilms and nanofilm-modified hydrogels were subjected to various extreme conditions to test their stability. like Figure 4 As shown, the nanomembrane modified hydrogel (A) in Example 1 was soaked in organic solvent ethanol, n-hexane, diethyl ether, chloroform and (B) extremely acid or extremely alkaline solution (pH=1 or pH= 12) for 12 hours, (C) sonicated in ultrapure water at 40 KHz for 30 min and (D) sonicated in 0.5 wt% polyoxyethylene ether aqueous solution at 40 KHz for 30 min, the nanofilm still adhered stably on the on the hydrogel.

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Abstract

The invention relates to a modified water-based material as well as a preparation method and application thereof, a protein film is adhered to the surface of the water-based material, and the protein film is a film formed by inducing protein by a modifier. The protein nano-film for modifying hydrogel / biological tissue not only has good stability, biocompatibility and excellent optical transparency, but also can entrap functional molecules, maintain the activity of the functional molecules and realize controllable release, and the protein film entrapped with the functional molecules can be used for modifying common commercial contact lenses. The prepared therapeutic contact lens can be applied to the field of ophthalmology, is simple and efficient in preparation process and low in cost, and has a good application prospect.

Description

technical field [0001] The invention relates to the field of materials, in particular to the application of a protein nano film on the surface of water-based materials, modified water-based materials, a preparation method of modified water-based materials, a composition of modified water-based materials and modified contact lenses. Background technique [0002] Through intermolecular forces such as hydrogen bonding, electrostatic interactions, and van der Waals interactions, the coating can achieve immediate adhesion upon contact with the dry material surface. However, this on-the-fly modification is difficult to achieve on wet surfaces such as hydrogels, because water separates the molecules of the coating and the hydrogel surface, preventing the coating-hydrogel from being necessary for durable adhesion. interaction. Although it is currently possible to modify the hydrogel surface by restricting the graft polymerization to occur only on the surface of the hydrogel, this m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/42A61K45/00A61K31/728A61K38/13A61P27/02C08L89/00C08J5/18G02C7/04G02B1/04
CPCA61K9/7007A61K47/42A61K45/00A61K31/728A61K38/13A61P27/02C08J5/18G02C7/049G02B1/043C08J2389/00
Inventor 杨鹏秦荣荣
Owner SHAANXI NORMAL UNIV