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Difunctional small organic molecule DATH for detecting and degrading acetaldehyde as well as preparation method and application of difunctional small organic molecule DATH

A bifunctional, small molecule technology, applied in chemical instruments and methods, hydrazide preparation, organic chemistry, etc., can solve the problems of low detection sensitivity, poor selectivity, and limited imaging applications of acetaldehyde, achieving high specificity and sensitivity High stability, high degradability, and wide detection range

Pending Publication Date: 2022-07-12
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems of low detection sensitivity, poor selectivity and limited imaging application of acetaldehyde in the prior art, the primary purpose of the present invention is to provide a bifunctional small organic molecule DATH for detection and degradation of acetaldehyde

Method used

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  • Difunctional small organic molecule DATH for detecting and degrading acetaldehyde as well as preparation method and application of difunctional small organic molecule DATH
  • Difunctional small organic molecule DATH for detecting and degrading acetaldehyde as well as preparation method and application of difunctional small organic molecule DATH
  • Difunctional small organic molecule DATH for detecting and degrading acetaldehyde as well as preparation method and application of difunctional small organic molecule DATH

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Example 1: Preparation of bifunctional organic small molecule DATH for detecting and degrading acetaldehyde

[0052] A preparation method of bifunctional organic small molecule DATH for detecting and degrading acetaldehyde, comprising the steps of:

[0053] (1) Add 1.96g (10mmol) 2,5-diaminoterephthalic acid, 30mL absolute ethanol and 2.1mL concentrated sulfuric acid to a 100mL round-bottomed flask equipped with a magnetic stirring bar, stir, reflux at 85°C for 12h, there is A large amount of red solid was formed, cooled to room temperature, and the solid was obtained by suction filtration, washed 3 times with water and 3 times with absolute ethanol to obtain the intermediate product:

[0054]

[0055](2) Add the intermediate product obtained in step (1) and 30 mL of absolute ethanol into a 100 mL round-bottomed flask equipped with a magnetic stirrer, add 6 mL of 80% hydrazine hydrate solution under stirring, stir at 85°C and heat under reflux for 12 h, and cool To ...

Embodiment 2

[0058] Example 2: Detection and Degradation of Acetaldehyde by Bifunctional Organic Small Molecule DATH Detection of Acetaldehyde

[0059] PBS buffer: prepare PBS buffer with pH=7.4 and concentration of 10mM;

[0060] Preparation of bifunctional organic small molecule DATH stock solution for detecting and degrading acetaldehyde: using dimethyl sulfoxide as a solvent to prepare a bifunctional organic small molecule DATH stock solution for detecting and degrading acetaldehyde with a final concentration of 10 mM;

[0061] Acetaldehyde stock solution with a final concentration of 10 mM: A stock solution of acetaldehyde with a final concentration of 10 mM was prepared with distilled water as the solvent.

[0062] The bifunctional organic small molecule DATH for detecting and degrading acetaldehyde was prepared according to the method described in Example 1.

[0063] 1. DATH, a bifunctional organic small molecule for detecting and degrading acetaldehyde, detects acetaldehyde

[00...

Embodiment 3

[0078] Example 3: Detecting and Degrading Acetaldehyde Bifunctional Organic Small Molecule DATH Detection and Mechanism Verification of Degrading Acetaldehyde

[0079] In a 1.5mL mass spectrometry sample vial, add 1mL of the bifunctional organic small molecule DATH stock solution (10mM) for the detection and degradation of acetaldehyde, and then add 30μL of pure ethyl acetate to the bifunctional organic small molecule DATH stock solution for the detection and degradation of acetaldehyde. Aldehyde was shaken uniformly to obtain a mixed solution; the molecular weight of the product in the mixed solution was detected by high-resolution mass spectrometry (Thermo Fisher Q Exactive ultra-high-resolution mass spectrometer).

[0080] Depend on Figure 7 and Figure 8 It can be seen that the bifunctional organic small molecule DATH for detecting and degrading acetaldehyde can react with four times the molar amount of acetaldehyde molecules, which proves that the bifunctional organic s...

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Abstract

The invention discloses a difunctional small organic molecule DATH for detecting and degrading acetaldehyde as well as a preparation method and application thereof, and belongs to the technical field of acetaldehyde detection and degradation. The difunctional small organic molecule DATH for detecting and degrading acetaldehyde is an acetaldehyde degradation reagent with high application value, and can quickly react with acetaldehyde with the molar weight 4 times that of the difunctional small organic molecule DATH. The difunctional small organic molecule DATH for detecting and degrading acetaldehyde is a stable and sensitive aldehyde group-containing compound, especially an acetaldehyde detection reagent, has the advantages of simple and convenient detection process, strong anti-interference capability, rapidness, sensitivity and accurate detection result, and has strong practical application value. The difunctional small organic molecule DATH for detecting and degrading acetaldehyde, which is prepared through esterification reaction and hydrazinolysis reaction, has relatively high specificity and sensitivity on acetaldehyde, is wide in detection range and rapid and convenient in detection process, and has relatively high degradation capacity on acetaldehyde.

Description

technical field [0001] The invention belongs to the technical field of acetaldehyde detection and degradation, in particular to a bifunctional organic small molecule DATH for detecting and degrading acetaldehyde, and a preparation method and application thereof. Background technique [0002] Acetaldehyde is a simple aldehyde compound with the molecular formula C 2 H 4 O, colorless and easy-flowing liquid with pungent odor, miscible with some organic substances such as water and ethanol. Acetaldehyde is often used in the production of dairy products, fruit flavors and fruit wines. An appropriate amount of acetaldehyde can make liquor and spirits have a unique flavor, and is the main source of the pungent flavor of liquor. In addition, a large amount of acetaldehyde exists in automobile exhaust and human necessities, which may cause water and environmental pollution. At the same time, acetaldehyde is also a by-product of cellular metabolism, which can react with genomic DN...

Claims

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Application Information

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IPC IPC(8): C07C243/38C07C241/04C09K11/06G01N21/64C02F1/58C02F101/34
CPCC07C243/38C07C241/04C07C227/18C09K11/06G01N21/6428C02F1/58C02F2101/34C07C229/62Y02A50/20
Inventor 朱伟郑观生
Owner SOUTH CHINA UNIV OF TECH
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