Continuous production method and device of meropenem side chain

Abstract

The invention provides a continuous production method and device for meropenem side chains, and the production method comprises the following steps: taking O powder and an activating agent as raw materials, and enabling the raw materials to sequentially pass through a first continuous reactor, an esterification post-treatment unit, a second continuous reactor, a vulcanization post-treatment unit, a third continuous reactor and a fourth continuous reactor, and successively carrying out an activation reaction, an esterification reaction, esterification post-treatment, a vulcanization reaction, vulcanization post-treatment, a cyclization reaction, an ester aminolysis reaction and ester aminolysis post-treatment to obtain the meropenem side chain. Wherein the first continuous reactor is provided with a first-stage reactor for performing activation reaction and a second-stage reactor for performing esterification reaction. According to the continuous production method, the dynamic pipeline reactor is adopted, the heat transfer and mass transfer effects of reactants are improved, the reaction time is effectively shortened, side reactions are effectively reduced, and therefore the input amount of raw materials is reduced, the product yield and quality are improved, and the aftertreatment process is simplified. Meanwhile, the discharge amount of three wastes is reduced, and the method is environment-friendly.

Description

technical field [0001] The invention belongs to the technical field of continuous green synthesis of fine chemical products, and particularly relates to a continuous production method and device for meropenem side chains. Background technique [0002] The side chain of meropenem is a key intermediate in the synthesis of meropenem, a very broad antimicrobial and injectable antibiotic used to treat many different infections, including meningitis and pneumonia. [0003] The CAS number of the side chain of meropenem is: 96034-64-9, and the molecular formula is: C 15 H 19 N 3 O 5 S, the molecular weight is 353.40, the density is: 1.36.0±0.1g / cm; the chemical structural formula is: [0004] [0005] The Chinese name of O powder is (4-nitrobenzyloxy)carbonyl-4-hydroxypyrrolidine-2-carboxylic acid, and the molecular formula is: C 13 H 14 N 2 O 7 , the molecular weight is 310.262, and the density is 1.37±0.2g / cm 3 , the chemical structure is: [0006] [0007] The syn...

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Problems solved by technology

[0011] The above synthesis schemes are all carried out in traditional tank reactors, which cannot achieve continuous production; and the reaction time is long due to the low heat and mass transfer efficiency of tank reactors, which brings the safety, environmental protection and auxiliary materials of the above analysis. Various problems such as excessive proportioning, product quality, product yield and cost

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