Preparation method and application of lubricating additive

A technology for lubricating additives and medicines, which is applied in the field of preparation of lubricating additives, can solve problems such as the preparation technology has not yet been established, and achieve the effects of improving drug loading efficiency, excellent lubrication and wear-reducing performance, and enhancing lubrication

Pending Publication Date: 2022-07-29
QUFU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, to the best of our knowledge, there are no studies on the use of FGQDs as joint lubricant additives while simultaneously visualizing drug loading, and the preparation technology has not yet been established.

Method used

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  • Preparation method and application of lubricating additive
  • Preparation method and application of lubricating additive
  • Preparation method and application of lubricating additive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] (1) Preparation of lubricant: Dissolve 15 mg of sodium hyaluronate (NaHA) solid in 1 mL of water and sonicate (200 W) until the solid is completely dissolved. A mixed solution of 0.5 mg of fluorinated graphene quantum dots (FGQDs) and 0.1 mg of DS was added, and sonicated (400 W) until uniformly dispersed to obtain 0.5 mg / mL of FGQDs-NaHA lubricant (fluorinated graphene quantum dots) The oxygen content is about 50%, and the fluorine content is about 30%; the molecular weight of sodium hyaluronate is 200,000 Da~400,000 Da).

[0038] (2) Tribological characterization of lubricants: The friction pair (zirconia balls and plates) were cleaned twice with ethanol (200 W) by ultrasonic waves, and the anhydrous ethanol was evaporated. Then, the friction coefficient of the prepared 0.5 mg / mL FGQDs-NaHA lubricant was tested with a TRB-3 reciprocating friction tester under the conditions of 5 N, 5 Hz, 25 °C, a reciprocating distance of 2 mm, and a test time of 30 min.

Embodiment 2

[0040] (1) Preparation of lubricant: Dissolve 15 mg of sodium hyaluronate (NaHA) solid in 1 mL of water and sonicate (200 W) until the solid is completely dissolved. Add a mixed solution of 1 mg of fluorinated graphene quantum dots (FGQDs) and 1 mg of DS, and ultrasonically (400W) to disperse uniformly to obtain 1 mg / mL of FGQDs-NaHA lubricant (containing fluorinated graphene quantum dots). The oxygen content is about 50%, and the fluorine content is about 30%; the molecular weight of sodium hyaluronate is 200,000 Da~400,000 Da).

[0041] (2) Tribological characterization of lubricants: The friction pair (zirconia balls and plates) were cleaned twice with ethanol (200 W) by ultrasonic waves, and the anhydrous ethanol was evaporated. Then, the friction coefficient of the prepared 1 mg / mL FGQDs-NaHA lubricant was tested with a TRB-3 reciprocating friction tester under the conditions of 5 N, 5 Hz, 25 °C, a reciprocating distance of 2 mm, and a test time of 30 min.

Embodiment 3

[0043](1) Preparation of lubricant: Dissolve 15 mg of sodium hyaluronate (NaHA) solid in 1 mL of water and sonicate (200 W) until the solid is completely dissolved. Add a mixed solution of 3 mg of fluorinated graphene quantum dots (FGQDs) and 2 mg of DS, and ultrasonically (400W) to disperse uniformly to obtain 3 mg / mL of FGQDs-NaHA lubricant (containing fluorinated graphene quantum dots). The oxygen content is about 50%, and the fluorine content is about 30%; the molecular weight of sodium hyaluronate is 200,000 Da~400,000 Da).

[0044] (2) Tribological characterization of lubricants: The friction pair (zirconia balls and plates) were cleaned twice with ethanol (200 W) by ultrasonic waves, and the anhydrous ethanol was evaporated. Then, the friction coefficient of the prepared 3 mg / mL FGQDs-NaHA lubricant was tested with a TRB-3 reciprocating friction tester under the conditions of 5 N, 5 Hz, 25 °C, a reciprocating distance of 2 mm, and a test time of 30 min.

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Abstract

The invention discloses a preparation method of a lubricating additive, a joint lubricant is prepared based on fluorinated graphene quantum dots (FGQDs), and a novel anti-inflammatory drug visual loading method based on the FGQDs is developed. The lubricating additive has good dispersion stability, high drug loading capacity and good antifriction and antiwear properties. By utilizing the spectroscopy property between the FGQDs and the anti-inflammatory drug, naked eye visual monitoring of drug loading is realized, and the efficiency of drug loading is greatly improved. The lubricating additive also has good biocompatibility and inflammation treatment effect, and can effectively improve the lubricating effect of the joint part and inhibit inflammation.

Description

technical field [0001] The invention belongs to the fields of mechanical engineering, material and biomedical technology and their intersections, and particularly relates to a preparation method and application of a lubricating additive. Background technique [0002] The friction and wear of cartilage caused by insufficient lubrication of human joints is an important cause of joint inflammation. Injecting hyaluronic acid can improve the lubrication of joints, but it is easy to degrade and requires frequent injections to supplement, which increases the chance of bacterial infection and the suffering of patients. Fluorinated graphene quantum dots (FGQDs) are a novel zero-dimensional carbon nanomaterial with ultra-small size and abundant fluorine functional groups, which can both induce positive bioresponsiveness and reduce surface energy. In particular, FGQDs not only inherit the excellent properties of fluorinated graphene such as high surface area, high mechanical strength,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/36A61K31/196A61K9/08A61P19/02A61P29/00
CPCA61K47/02A61K47/36A61K31/196A61K9/08A61P19/02A61P29/00
Inventor 公培伟戚长敏刘哲王丹丹宗佳霖刘建喜蔡美荣刘维民
Owner QUFU NORMAL UNIV
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