Nonmetal temperature-responsive magnetic resonance imaging composite material as well as preparation method and application thereof

A temperature-responsive, magnetic resonance imaging technology, used in pharmaceutical formulations, preparations for in vivo experiments, etc., can solve problems such as limited application, inability to directly reflect cell proliferation, allergies, etc.

Active Publication Date: 2022-07-29
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] However, the above disclosed technical solutions have the following problems: (1) the disclosed temperature-responsive contrast agent technology needs to generate an additional magnetic field (usually provided by metal atoms) in the use environment, and this type of contrast agent injection in the human body will Cause allergic and other discomfort reactions (see Semelka R C et al. Magnetic Resonance Imaging, 2016, 34(10): 1399-1401 and Daldruplink H E. Radiology, 2017, 284(3): 616-629 reports); (2) have been Disclosed that temperature-influenced contrast agents switch between high and low relaxation efficiencies with temperature, rather than "on" and "off" contrast effects, so the injected area is always in contrast
As a result, the signal generated by the cells migrating into the polymer material will also be changed by the contrast agent. Regardless of the state of the contrast agent’s contrast efficiency, the MRI signal intensity cannot directly reflect the value-added situation of the cells inside the polymer material. Limit its application in fields such as tissue engineering scaffolds

Method used

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  • Nonmetal temperature-responsive magnetic resonance imaging composite material as well as preparation method and application thereof
  • Nonmetal temperature-responsive magnetic resonance imaging composite material as well as preparation method and application thereof
  • Nonmetal temperature-responsive magnetic resonance imaging composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Polybutylene succinate was dissolved in chloroform to form a polymer solution with a mass concentration of 60%, and lauric acid was dissolved in dichloromethane to form a contrast agent solution with a mass concentration of 75%; The spinning solution was obtained after mixing in a ratio of 1:2.

[0059] Electrospin the solution through the following parameters, the liquid supply rate of the liquid supply device is 3mL / h, the distance between the spinneret and the collection device is 20cm, the high voltage of 20kV is connected to the spinneret, and the high voltage of -1kV is connected to the collection device.

[0060] The collected composite fiber product is dried, immersed in water, and the air in the fiber is exhausted.

[0061] The response temperature of the fibers was 44.2°C, as measured by differential scanning calorimetry.

Embodiment 2

[0063] Polyethylene terephthalate was dissolved in chloroform to form a polymer solution with a mass concentration of 45%, and lauryl alcohol was dissolved in dichloromethane to form a contrast agent solution with a mass concentration of 75%; The spinning solution was obtained after mixing in a mass ratio of 1:2.

[0064] Electrospin the solution through the following parameters, the liquid supply rate of the liquid supply device is 3mL / h, the distance between the spinneret and the collection device is 20cm, the high voltage of 20kV is connected to the spinneret, and the high voltage of -1kV is connected to the collection device.

[0065] The collected composite fiber product is dried, immersed in water, and the air in the fiber is exhausted.

[0066] The response temperature of the fibers was 24.0°C as measured by differential scanning calorimetry.

[0067] In order to illustrate that the organic hydrogen-containing molecular contrast agent used in the present invention prov...

Embodiment 3

[0069] Dissolving polyvinyl alcohol in water to form a polymer solution with a mass concentration of 5%, and dissolving glycerol trimyristate in tetrahydrofuran to form a contrast agent solution with a mass concentration of 60%; the two solutions were mixed in a mass ratio of 1:2 After mixing, a spinning solution is obtained.

[0070] Electrospin the solution through the following parameters, the liquid supply rate of the liquid supply device is 0.1 mL / h, the distance between the spinneret and the collecting device is 50 cm, the high voltage 50kV is connected to the spinneret, and the high voltage -1kV is connected to the collecting device.

[0071] The collected composite fiber product is dried, immersed in water, and the air in the fiber is exhausted.

[0072] The response temperature of the fibers was 56.2°C as measured by differential scanning calorimetry.

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Abstract

The invention belongs to the field of functional fiber materials, and discloses a non-metal temperature-responsive magnetic resonance imaging composite material as well as a preparation method and application thereof. An organic hydrogen-containing molecule contrast agent is loaded in polymer fibers through an electrostatic spinning technology, and the relaxation time of the organic hydrogen-containing molecule contrast agent is regulated and controlled by controlling the phase structure and molecular movement ability of the organic hydrogen-containing molecule contrast agent. Under the condition that an additional magnetic field is not added, temperature-responsive magnetic resonance imaging with an on/off effect is realized for a high polymer material. Compared with the prior art, an additional magnetic field does not need to be added; the selected contrast agent can be extracted from a plant/animal body and is non-toxic to a human body; the advantages that the on/off radiography effect can be achieved, and the nuclear magnetic signal of the material is not affected when the radiography is not carried out are achieved.

Description

technical field [0001] The invention belongs to the field of functional fiber materials, and more particularly, relates to a non-metallic temperature-responsive magnetic resonance imaging composite material and a preparation method and application thereof. Background technique [0002] Magnetic Resonance Imaging (MRI) [0003] Magnetic resonance is a physical phenomenon in which the nucleus of an atom resonates with an external magnetic field under certain conditions. The basic working principle of Magnetic Resonance Imaging (MRI) is to place the measured object in a special magnetic field, and use radio frequency pulses to excite the hydrogen nuclei in the object, causing the hydrogen nuclei to resonate and absorb energy. After the radio frequency pulses are stopped, the hydrogen nuclei release the absorbed energy and emit radio signals at specific frequencies. This radio signal is collected by the receiver of the MRI equipment and processed by a computer to obtain an ima...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/12A61K49/14
CPCA61K49/12A61K49/14
Inventor 王林格贾毅凡于倩倩
Owner SOUTH CHINA UNIV OF TECH
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