Nonmetal temperature-responsive magnetic resonance imaging composite material as well as preparation method and application thereof

Abstract

The invention belongs to the field of functional fiber materials, and discloses a non-metal temperature-responsive magnetic resonance imaging composite material as well as a preparation method and application thereof. An organic hydrogen-containing molecule contrast agent is loaded in polymer fibers through an electrostatic spinning technology, and the relaxation time of the organic hydrogen-containing molecule contrast agent is regulated and controlled by controlling the phase structure and molecular movement ability of the organic hydrogen-containing molecule contrast agent. Under the condition that an additional magnetic field is not added, temperature-responsive magnetic resonance imaging with an on / off effect is realized for a high polymer material. Compared with the prior art, an additional magnetic field does not need to be added; the selected contrast agent can be extracted from a plant / animal body and is non-toxic to a human body; the advantages that the on / off radiography effect can be achieved, and the nuclear magnetic signal of the material is not affected when the radiography is not carried out are achieved.

Description

technical field [0001] The invention belongs to the field of functional fiber materials, and more particularly, relates to a non-metallic temperature-responsive magnetic resonance imaging composite material and a preparation method and application thereof. Background technique [0002] Magnetic Resonance Imaging (MRI) [0003] Magnetic resonance is a physical phenomenon in which the nucleus of an atom resonates with an external magnetic field under certain conditions. The basic working principle of Magnetic Resonance Imaging (MRI) is to place the measured object in a special magnetic field, and use radio frequency pulses to excite the hydrogen nuclei in the object, causing the hydrogen nuclei to resonate and absorb energy. After the radio frequency pulses are stopped, the hydrogen nuclei release the absorbed energy and emit radio signals at specific frequencies. This radio signal is collected by the receiver of the MRI equipment and processed by a computer to obtain an ima...

AI Technical Summary

Problems solved by technology

[0017] However, the above disclosed technical solutions have the following problems: (1) the disclosed temperature-responsive contrast agent technology needs to generate an additional magnetic field (usually provided by metal atoms) in the use environment, and this type of contrast agent injection in the human body will Cause allergic and other discomfort reactions (see Semelka R C et al. Magnetic Resonance Imaging, 2016, 34(10): 1399-1401 and Daldruplink H E. Radiology, 2017, 284(3): 616-629 reports); (2) have been Disclosed that temperature-influenced contrast agents switch between high and low relaxation efficiencies with temperature, rather than "on" and "off" contrast effects, so the injected area is always in contrast

As a result, the signal generated by the cells migrating into the polymer material will also be changed by the contrast agent. Regardless of the state of the contrast agent’s contrast efficiency, the MRI signal intensity cannot directly reflect the value-added situation of the cells inside the polymer material. Limit its application in fields such as tissue engineering scaffolds

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