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Soft tissue-like elastic hydrogel and preparation method and application of hydrogel tissue organ model thereof

A tissue organ and hydrogel technology, applied in teaching models, instruments, educational appliances, etc., can solve the problem of poor mechanical properties of elastic hydrogel, lack of elastic hydrogel, and difficulty in directly constructing vascular channels and heterogeneous structures Organ models and other issues, to achieve good strength and good toughness

Pending Publication Date: 2022-08-05
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there is still a lack of effective methods to tune the mechanical properties of elastic hydrogels to match various natural soft tissues.
In addition, the mechanical properties of elastic hydrogels are poor, and it is difficult to directly construct tissue and organ models with vascular channels and heterogeneous structures, which is the biggest challenge in the field of artificial hydrogel tissue and organ model construction.

Method used

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  • Soft tissue-like elastic hydrogel and preparation method and application of hydrogel tissue organ model thereof
  • Soft tissue-like elastic hydrogel and preparation method and application of hydrogel tissue organ model thereof
  • Soft tissue-like elastic hydrogel and preparation method and application of hydrogel tissue organ model thereof

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preparation example Construction

[0061] The invention provides a preparation method of a kind of soft tissue elastic hydrogel, comprising the following steps:

[0062] Mixing acrylamide monomer, unsaturated double bond monomer containing negative electron group, water-soluble photoinitiator, crosslinking agent, light absorber and water to obtain a hydrogel photocurable ink solution;

[0063] photocuring the hydrogel photocurable ink solution to obtain a photocurable hydrogel precursor;

[0064] soaking the photocurable hydrogel precursor in a zirconium salt solution to carry out a metal coordination reaction to obtain a photocurable hydrogel precursor enhanced by metal coordination;

[0065] The metal coordination-enhanced photocurable hydrogel precursor is soaked in water to perform ion balance to obtain a soft tissue-like elastic hydrogel.

[0066] In the present invention, acrylamide monomer, unsaturated double bond monomer containing negative electron group, water-soluble photoinitiator, crosslinking age...

Embodiment 1

[0102] 25.6g acrylamide, 8.3g 2-acrylamide-2-methylpropanesulfonic acid, 0.17g phenyl(2,4,6-trimethylbenzoyl) phosphate lithium salt, 0.09g methylenebispropylene Amide and 0.01g of tartrazine were fully dissolved in 100mL of deionized water, and the hydrogel precursor solution was obtained after deoxidizing with nitrogen gas; the hydrogel precursor solution was photocured for 3min under 500mW light intensity to obtain photocured water. gel; immersing the photocurable hydrogel in a 0.1 mol / L zirconium oxychloride salt solution for 5 days to carry out a metal coordination reaction to obtain a photocurable hydrogel enhanced by metal coordination; finally the metal The coordination-enhanced photocurable hydrogel was immersed in water and ion-equilibrated for 5 days to obtain a soft tissue-like elastic hydrogel.

[0103] The scanning electron microscope image of the obtained soft tissue-like elastic hydrogel is shown in Fig. image 3 shown. Depend on image 3 It can be seen that...

Embodiment 2

[0106] 25.6g acrylamide, 8.3g 2-acrylamide-2-methylpropanesulfonic acid, 0.17g phenyl(2,4,6-trimethylbenzoyl) phosphate lithium salt, 0.09g methylenebispropylene Amide and 0.01 g of tartrazine were fully dissolved in 100 mL of deionized water, and a photocurable printed hydrogel ink was obtained after deoxidizing with nitrogen.

[0107] The prepared photocurable printing hydrogel ink was transferred to the photocurable 3D printer material box, and the STL file of the ear tissue and organ model was established by 3D modeling software, and imported into the 3D printer software for slicing processing to obtain slice data; It is 405nm, the single-layer slice thickness is 0.1mm, the single-layer exposure time is 15s, the light intensity of the light source is 500mW, and the printing environment temperature is room temperature.

[0108] The light-cured tissue-organ model was immersed in 0.10 mol / L zirconium oxychloride solution for metal coordination treatment for 5 days; the metal ...

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Abstract

The invention provides soft tissue-like elastic hydrogel as well as a preparation method and application of a tissue and organ model of the soft tissue-like elastic hydrogel, and belongs to the technical field of hydrogel-based tissue and organ model manufacturing. Acrylamide and an unsaturated double-bond monomer containing a negative electron group are subjected to photocuring to form a covalent cross-linked network, then the negative electron group is coordinated with zirconium ions to form an ionic cross-linked network, and the controllable dual-network elastic hydrogel with the mechanical property close to that of soft tissue is constructed. By means of the advantage of constructing a fine structure by means of a photocuring rapid prototyping technology, various personalized tissue and organ models matched with natural soft tissues can be printed and prepared, and the contradiction between the mechanical property and the processability of a soft material is solved. The elastic hydrogel provided by the invention is simple and feasible in preparation method, has adjustable and controllable mechanical properties, can be better matched with soft tissues, can simulate mechanical behaviors of human soft tissues, and is expected to be applied to the medical fields of medical preoperative simulation, organ transplantation and surgical resection.

Description

technical field [0001] The invention relates to the technical field of hydrogel-based tissue-organ model manufacturing, in particular to a preparation method and application of a soft tissue-like elastic hydrogel and a tissue-organ model thereof. Background technique [0002] Human tissue and organ models are an important means for doctors to use for preoperative simulation and medical teaching. For example, in clinical diagnosis, when doctors perform interventional surgery (cardiovascular and tumor interventional therapy), they need to know in advance the size of blood vessels and tissues and organs, the location of diseased tissues and their spatial relationships, so as to make adequate surgical plans and plans, evaluate Possible risks of surgery and taking steps to deal with potential risks. In addition, artificial tissue and organ models are also required to carry out simulation experiments in the process of robotic surgery training. Compared with traditional living ti...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J7/12C08L33/26C08F220/56C08F220/58C08F222/38G09B23/28
CPCC08J3/075C08J7/12C08F220/56G09B23/28C08J2333/26C08F220/585C08F222/385
Inventor 王晓龙刘德胜蒋盼吴家宇周峰刘维民
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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