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Multilayer microencapsulated mild composite acid repair gel based on lactic acid bacteria fermentation product EPS and preparation method and application thereof

A technology of lactic acid bacteria fermentation and lactic acid bacteria fermentation liquid, which is applied in the field of skin care products, can solve the problems of chemical skin peeling agents that have not yet been discovered, achieve the effect of removing acne and acne, repairing and rejuvenating the skin, taking into account effectiveness and safety, and ensuring safety Effect

Pending Publication Date: 2022-08-09
绽妍生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no precedent for compounding specific lactic acid bacteria exopolysaccharides with different monoacids into chemical skin peeling agents

Method used

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  • Multilayer microencapsulated mild composite acid repair gel based on lactic acid bacteria fermentation product EPS and preparation method and application thereof
  • Multilayer microencapsulated mild composite acid repair gel based on lactic acid bacteria fermentation product EPS and preparation method and application thereof
  • Multilayer microencapsulated mild composite acid repair gel based on lactic acid bacteria fermentation product EPS and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 mild complex acid repair gel

[0029] By weight, the formula is: 23 parts of lactic acid bacteria fermentation extract, 15 parts of salicylic acid, 1 part of octanoyl salicylic acid, 2 parts of glycolic acid, 3 parts of mandelic acid, 1 part of citric acid, 1 part of lactic acid, 5 parts of Wen 80 and 49 parts of water.

[0030] The lactic acid bacteria fermentation extract is an extracellular polysaccharide isolated from traditional dairy products in pastoral areas.

Embodiment 2

[0031] Example 2 mild complex acid repair gel

[0032] By weight, the formula is: 23 parts of lactic acid bacteria fermentation extract, 15 parts of salicylic acid, 1 part of octanoyl salicylic acid, 2 parts of glycolic acid, 3 parts of mandelic acid, 1 part of citric acid, 1 part of lactic acid, 5 parts of Wen 80 and 49 parts of water.

[0033] The lactic acid bacteria fermentation extract is as follows: inoculate a single colony of lactic acid bacteria (Lactobacillus plantarum AS 1.555) in MRS medium for activation and culture at 37°C for 24 hours to obtain seed liquid, and inoculate the seed liquid into the MRS medium according to the inoculation amount of 4w / w% Then, the fermentation culture is carried out, and the fermentation culture temperature is 37° C., and after the fermentation culture is performed for 72 hours, the lactic acid bacteria fermentation broth is obtained. The lactic acid bacteria fermentation broth was centrifuged at 2000 rpm for 10 min, the supernatan...

Embodiment 3

[0034] Example 3 mild complex acid repair gel

[0035] By weight, the formula is: 23 parts of lactic acid bacteria fermentation extract, 15 parts of salicylic acid, 1 part of octanoyl salicylic acid, 2 parts of glycolic acid, 3 parts of mandelic acid, 1 part of citric acid, 1 part of lactic acid, 5 parts of Wen 80 and 49 parts of water.

[0036] The lactic acid bacteria fermentation extract is as follows: inoculate a single colony of lactic acid bacteria (Lactobacillus plantarum AS 1.555) in MRS medium for activation and culture at 37° C. for 24 hours to obtain seed liquid, and inoculate the seed liquid according to the inoculation amount of 4w / w% to a concentration of 0.02 g / L threonine MRS medium for fermentation culture, fermentation culture temperature is 37 ℃, fermentation culture is 72h, and lactic acid bacteria fermentation broth is obtained. The lactic acid bacteria fermentation broth was centrifuged at 2000 rpm for 10 min, the supernatant was taken, and the componen...

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Abstract

The invention discloses a multi-layer microencapsulated mild composite acid repair gel based on a lactic acid bacteria fermentation product EPS and a preparation method and application of the multi-layer microencapsulated mild composite acid repair gel. The composite acid repair gel comprises the following components: a lactobacillus fermentation extract, salicylic acid, capryloyl salicylic acid, glycolic acid, mandelic acid, citric acid and lactic acid. The preparation method of the lactic acid bacteria fermentation extract comprises the following steps: inoculating a lactic acid bacteria seed solution into a fermentation culture medium for culturing to obtain a lactic acid bacteria fermentation solution; the fermentation culture medium contains threonine and serine. The mild repairing gel obtained by adopting a 1 + N formula and an exclusive multi-layer micro-capsule wrapping technology can solve the problems of irritation and dissolution of salicylic acid and capryloyl salicylic acid, can slowly release effective components at a constant speed, more accurately acts on each layer of skin, efficiently plays the acne removing and skin repairing effects, and takes both effectiveness and safety into account.

Description

technical field [0001] The invention belongs to the technical field of skin care products, and in particular relates to a multi-layer microencapsulated mild compound acid repair gel based on a lactic acid bacteria fermentation product EPS, and a preparation method and application thereof. Background technique [0002] Compound acid refers to a new type of chemical peeling agent made by compounding two or more different types of monoacids with different action mechanisms through a special process, which can be made into dosage forms such as gels. Through reasonable compatibility and preparation process, the action mechanisms of different monoacids can make up for each other (1+1>2), penetrate into different skin levels, act on the skin at multiple targets, and enhance the curative effect; greatly reduce the effect of monoacids concentration, improve safety and reduce side effects. At present, there are a variety of compound acid products on the market, but the quality is ...

Claims

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Application Information

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IPC IPC(8): A61K8/99A61K8/368A61K8/365A61K8/04A61Q19/00C12N1/20C12R1/225
CPCA61K8/99A61K8/368A61K8/365A61K8/042A61Q19/00C12N1/20A61K2800/10A61K2800/805A61K2800/63A61K2800/622Y02A40/90
Inventor 舒凌祖月榕
Owner 绽妍生物科技有限公司
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