Long-acting tretnoin intraocular slow-releasing system
A retinoic acid, long-acting technology, applied in non-active ingredients medical preparations, anhydride/acid/halide active ingredients, sensory diseases, etc., can solve the problems of non-availability, increased drug release, etc., and achieve high drug effect. Effect
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Embodiment 1
[0018] Copolymer (lactic acid / glycolic acid) (PLGA) (molecular weight: 110,000) 15 parts, dissolve with 20 parts of dichloromethane, add 10 parts of retinoic acid powder, stir evenly, pour into polytetrafluoroethylene mold, control the airflow speed, make dichloromethane Methane evaporates. After being completely dried, this copolymer (lactic acid / glycolic acid) drug slow-release system containing retinoic acid was taken off from the polytetrafluoroethylene mold, kept in a vacuum oven at room temperature for 48 hours to completely remove the solvent, and obtained a thickness of 2 mm, in the form of sheet-like medicaments with 10 nanometer pores, and then use a die with an aperture of 2 mm to punch a retinoic acid sustained-release system with a thickness of 2 mm and a diameter of 2 mm. The retinoic acid slow-release system was fumigated with ethylene oxide for 24 hours, sterilized and sterilized, and placed in the vitreous cavity of the rabbit eye after being placed for anothe...
Embodiment 2
[0022] According to the method and steps of Example 1, but adopting 10 parts of poly DL-lactic acid (PDLLA) (molecular weight 60,000), 20 parts of methylene chloride and 4 parts of retinoic acid, a medicine rod with a diameter of 2 mm is obtained, and a diameter of 2 mm is obtained. 2 mm, pore structure of 10 nanometers of drug rods, kept in a vacuum oven at room temperature for 48 hours to completely remove the solvent and then cut into 2 mm long retinoic acid sustained-release system. The retinoic acid slow-release system was sterilized by fumigation with ethylene oxide for 24 hours, placed for another week, and then implanted into the vitreous cavity of the rabbit eye in the same manner as in Example 1. The results of postoperative macroscopic observation and local histopathological examination showed that the retinoic acid sustained-release system has good intraocular biocompatibility, and retinoic acid can maintain a certain concentration in the aqueous humor within 10 wee...
Embodiment 3
[0024] According to the method and steps of Example 1, but using (prepared by the method of Chinese invention patent application number 99105984.0) (glycolic acid / lactic acid / caprolactone) terpolymer (PGLC) (molecular weight 80,000) 10 parts, dichloro 18 parts of methane and 9 parts of retinoic acid were used to obtain a block with a length of 10 mm on each side, which was kept in a vacuum oven at room temperature for 48 hours to completely remove the solvent and then cut into a 2 mm square retinoic acid sustained-release system. The retinoic acid slow-release system was sterilized by fumigation with ethylene oxide for 24 hours, placed for another week, and then implanted into the vitreous cavity of the rabbit eye in the same manner as in Example 1.
[0025] The results of postoperative macroscopic observation and local histopathological examination showed that the retinoic acid sustained-release system has good intraocular biocompatibility. The retinoic acid can maintain a cer...
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