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Freeze-dried powder injection of Corydalis thalictrifolia franch for curing hepatitis, large dise transfusion medicine preparation method

A freeze-dried powder injection and anti-hepatitis technology, which is applied in freeze-dried delivery, powder delivery, drug delivery, etc., can solve the problems of petridine base being unstable when exposed to light, inconvenient to carry, transport and store, and affect drug stability, etc., to achieve effective Benefits of long-term storage, shorter treatment time, good market prospects and social benefits

Inactive Publication Date: 2005-10-26
陕西天森药物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the anti-hepatitis Yanhuanglian injection small injection made of the traditional Chinese medicine Yanhuanglian as the main component is injected intramuscularly, and the therapeutic effect is relatively slow. In addition, there are the following deficiencies. First, it is inconvenient to use. It is necessary to break the ampoule first, which will inevitably cause the ampoule to fall into pieces more or less; secondly, when the small injection is produced and sealed, it needs to be given local high temperature, which will inevitably affect the quality of the drug. Stability; thirdly, the main component of the drug, petrizine, is unstable when exposed to light, and the drug in the small injection is highly dispersed to increase the photosensitive surface, which makes the drug easy to deteriorate and unstable; fourth, the small injection ampoule is fragile and fragile, so it is easy to carry, transport and store inconvenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1: Preparation of anti-hepatitis drug freeze-dried powder injection

[0019] The method for preparing antihepatitis drug freeze-dried powder injection comprises the steps:

[0020] Grind rhizoma rhizome into coarse powder, weigh the coarse powder, soak with 5 times the amount of 90% ethanol for 24 hours, reflux extraction 4 times, each time for 1 hour, combine the extracts, recover ethanol under reduced pressure and concentrate to a relative density of 0.92- The clear paste of 1.02 is allowed to cool, filtered, and the filtrate is concentrated to a thick paste with a relative density of 1.16-1.20. Add distilled water to the thick paste, precipitate brown precipitated water, adjust the pH value to 2-3 with 10% hydrochloric acid solution, stir well, filter, wash 4-5 times with 10% hydrochloric acid solution, combine acid water, sodium carbonate Adjust the pH value to 9-10, precipitate a tan precipitate, filter, and extract the filter residue with 5 times the a...

Embodiment 2

[0021] Embodiment 2: Preparation of large infusion of anti-hepatitis drugs

[0022] Steps for preparing large infusion of anti-hepatitis drugs:

[0023] Grind rhizoma rhizome into coarse powder, weigh the coarse powder, soak with 5 times the amount of 90% ethanol for 24 hours, reflux extraction 4 times, each time for 1 hour, combine the extracts, recover ethanol under reduced pressure and concentrate to a relative density of 0.92- The clear paste of 1.02 is allowed to cool, filtered, and the filtrate is concentrated to a thick paste with a relative density of 1.16-1.20. Add distilled water to the thick paste, precipitate brown precipitated water, adjust the pH value to 2-3 with 10% hydrochloric acid solution, stir well, filter, wash 4-5 times with 10% hydrochloric acid solution, combine acid water, sodium carbonate Adjust the pH value to 9-10, precipitate a tan precipitate, filter, and extract the filter residue with 5 times the amount of chloroform for 5-6 times, combine the...

Embodiment 3

[0024] Embodiment 3: Preparation of anti-hepatitis drug freeze-dried powder injection composition

[0025] According to the weight ratio, it contains 1 part of active ingredient of rhizome and 185 parts of auxiliary materials. Wherein the solubilizer polybehenate 10 parts, polyethylene glycol 5 parts. Filler lactose 30 parts, mannitol 140 parts.

[0026] The steps of preparing the drug freeze-dried powder injection:

[0027] Grind rhizoma rhizome into coarse powder, weigh the coarse powder, soak with 5 times the amount of 90% ethanol for 24 hours, reflux extraction 4 times, each time for 1 hour, combine the extracts, recover ethanol under reduced pressure and concentrate to a relative density of 0.92- The clear paste of 1.02 is allowed to cool, filtered, and the filtrate is concentrated to a thick paste with a relative density of 1.16-1.20. Add distilled water to the thick paste, precipitate brown precipitated water, adjust the pH value to 2-3 with 10% hydrochloric acid sol...

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PUM

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Abstract

The present invention relates to a kind of freeze-dried powder injection for curing hepatitis, its medicine composition for fluid infusion and their preparation method. The freeze-dried powder injection composition contains 1 portion of effective component extracted from root of meadowrueleaf corydalis and 50-500 portions of auxiliary material, and the medicine composition for fluid infusion contains 1 portion of effective component of root of meadowrueleaf corydalis and 800-1000 portions of auxiliary material, and their preparation method includes the following steps: decocting root of meadowrueleaf corydalis, separating and purifying to obtain its extract, mixing it with auxiliary material uniformly, dissolving them in injection water, filtering, filling and sterilizing so as to obtain the invented product.

Description

technical field [0001] The invention relates to a preparation method of the anti-hepatitis drug Litectin, in particular to a preparation method of the anti-hepatitis drug Litectin freeze-dried powder injection and large infusion solution which can be used for intravenous injection. Background technique [0002] At present, the anti-hepatitis Yanhuanglian injection small injection made of the traditional Chinese medicine Yanhuanglian as the main component is injected intramuscularly, and the therapeutic effect is relatively slow. In addition, there are the following deficiencies. First, it is inconvenient to use. It is necessary to break the ampoule first, which will inevitably cause the ampoule to fall into pieces more or less; secondly, when the small injection is produced and sealed, it needs to be given local high temperature, which will inevitably affect the quality of the drug. Stability; thirdly, the main component of the drug, petrizine, is unstable when exposed to li...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K9/19A61P1/16A61P31/12
Inventor 毛幼桦
Owner 陕西天森药物研究开发有限公司
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