Process for preparing aspartame
A technology of aspartame and aspartic acid, applied in the direction of peptides, etc., can solve the problems of low yield of aspartame products, long reaction cycle, long process, etc., and achieve convenient post-processing and reuse and low processing cost Low, highly selective effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0027] A 500ml four-neck round bottom flask with mechanical stirring, thermometer, condenser. Add 160g of 50wt% sodium hydroxide solution into the flask, cool to 0°C, add 133g of L-aspartic acid in batches, and keep the temperature below 0°C. After the addition, 150 g of ethyl thiomethyl formate and 80 g of methanol were added. Slowly raise the temperature to 45°C and stir for 2 hours. After the feed liquid was cooled to room temperature, it was left to stand for 1 hour, and the feed liquid was separated. Cool the water layer to 0°C, slowly add 180ml of concentrated hydrochloric acid with a content of 35wt%, adjust the pH to about 3, add 600ml of ethyl acetate for extraction in 3 times, combine the extracts, wash once with saturated saline, and add the feed solution to 15g of anhydrous magnesium sulfate was dried. Filter and collect the filtrate for concentration. The concentrated solution was filtered again, and the filter cake was dried to obtain 200 g of acylate, with a...
Embodiment 2
[0032] A 500ml four-neck round bottom flask with mechanical stirring, thermometer, condenser. Add 160g of sodium hydroxide solution with a content of 50wt% into the flask, cool to 0°C, add 133g of L-aspartic acid in batches, and keep the temperature below 0°C. After the addition, 150 g of ethyl thiomethyl formate and 80 g of methanol were added. Slowly raise the temperature to 50°C, and stir the reaction for 2 hours. Then, after the feed liquid was cooled to room temperature, it was allowed to stand for 1 hour, and the feed liquid was separated. Then the separated water layer was cooled to 10°C, and 150ml of 35wt% concentrated hydrochloric acid was slowly added to adjust the pH to about 3.5; 600ml of ethyl acetate was added in 3 times for extraction, the combined extracts were washed once with saturated brine . Add 15 g of anhydrous magnesium sulfate to the washed feed liquid to dry, filter, and collect the filtrate for concentration. The concentrate was filtered again, an...
Embodiment 3
[0037] A 500ml four-neck round bottom flask with mechanical stirring, thermometer, condenser. Add 120g of 50wt% sodium hydroxide solution into the flask, cool to 0°C, add 133g of L-aspartic acid in batches, and keep the temperature below 0°C. After the addition, 150 g of ethyl thiomethyl formate and 80 g of methanol were added. Slowly raise the temperature to 45°C and stir for 2 hours. After the feed liquid was cooled to room temperature, it was left to stand for 1 hour, and the feed liquid was separated. Then the separated water layer was cooled to 0°C, and 180ml of concentrated hydrochloric acid with a content of 35wt% was slowly added to adjust the pH to about 3, and 600ml of ethyl acetate was added for extraction in 3 times, the combined extracts were washed once with saturated saline . Add 15g of anhydrous magnesium sulfate to the washed feed liquid to dry. Filter and collect the filtrate for concentration. The concentrated solution was filtered again, and the filter...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More