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Low-temperature ultramicro disintegrating method of Chinese traditional medicinal materials

A low-temperature ultrafine pulverization and ultrafine pulverization technology, which is applied in the direction of making medicines into special physical or ingestible devices, grain processing, etc., can solve the problems of affecting biological activity, contamination of pharmaceutical raw materials, and reduction of mechanical properties.

Inactive Publication Date: 2006-12-13
SUN YAT SEN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mechanical equipment used in this field, such as ultra-fine grinding, micro-grinding, ultra-fine grinding and other devices came into being, through strong extrusion, shearing, impact, impact, collision, grinding, friction, cutting rubbing, cavitation explosion, Mechanical pulverization such as turbulence, although it can achieve the purpose of ultrafine pulverization of materials, it also causes the materials to undergo ultrafine pulverization during the process of ultrafine pulverization such as metal material impact and grinding parts, impact, collision, grinding, cutting, rubbing, and friction. Heat generation, reduce mechanical properties, and affect the biological activity of ultra-finely pulverized materials, and at the same time, different degrees of heavy metal powder particles are peeled off and released, such as chromium, nickel, cadmium, titanium, iron, copper, zinc, lead, arsenic and other heavy metals , so that the drug raw materials are seriously polluted during the ultrafine pulverization process and lose their original medicinal value

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. The monoclinic phase pure zirconia raw material is 98.7%, the purity is 92%, and the particle size is 0.5-0.8μm.

[0018] 2. Select 0.9% of nano-alumina, 0.2% of yttrium oxide, and 0.2% of calcium oxide, and the purity of the raw material of the toughening agent is 95-96%.

[0019] 3. The cylinder lining and grinding body specifications of the vibrating mill are prefabricated according to the cylinder model specifications. The thickness of the cylinder lining is 56mm; the diameter of the ball grinding body is 29mm.

[0020] 4. The sintering temperature of the green body of the high-strength ceramic cylinder lining and grinding body is 1610°C.

[0021] 5. Embed the prepared high-strength ceramic cylinder lining in the vibration mill cylinder, and place 420 pieces of high-toughness ceramic ball mills.

[0022] 6. When crushing materials, spray coolant nitrogen dioxide into the barrel during the crushing process, and the injection amount is 0.3 times the weight of the ...

Embodiment 2

[0025] 1. The monoclinic phase pure zirconia raw material is 95%, the purity is 95%, and the particle size is 0.6-0.7μm.

[0026] 2. The toughening agent is 4% of nano-alumina and 1% of yttrium oxide, and the purity of the raw material of the toughening agent is 99.2%.

[0027] 3. The specifications of the cylinder lining and grinding body of the vibrating mill are prefabricated according to the cylinder model specification. The thickness of the cylinder lining is 63mm; the diameter of the ball mill is 38mm.

[0028] 4. The sintering temperature of the green body of the high-toughness ceramic cylinder lining and grinding body is 1570°C.

[0029] 5. Embed the prepared high-toughness ceramic cylinder liner in the vibrating mill cylinder, and place 350 pieces of high-toughness ceramic ball mills.

[0030] 6. When crushing materials, the coolant dry ice is sprayed into the barrel during the crushing process, and the injection amount is 0.25 times the weight of the crushed materia...

Embodiment 3

[0033] 1. Chemical co-precipitation process zirconia raw material 91%, purity 99.5%, particle size 0.7-0.9μm.

[0034] 2. Select 6% of nano-alumina and 3% of yttrium oxide as toughening agents, and the purity of the toughening agent raw materials is 99.3%.

[0035] 3. The specifications of the cylinder lining and grinding body of the vibrating mill are prefabricated according to the cylinder model specifications. The thickness of the cylinder lining is 41mm; the diameter of the short cylinder is 33mm and the length is 50mm.

[0036] 4. The sintering temperature of the green body of the high-strength ceramic cylinder lining and grinding body is 1598°C.

[0037] 5. Embed the prepared high-strength ceramic cylinder liner into the vibration mill cylinder, and place 410 pieces of high-toughness ceramic short cylinders.

[0038] 6. When crushing materials, the crushed raw materials are frozen to -60°C by ultra-low temperature.

[0039] 7. According to the test, the temperature of ...

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PUM

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Abstract

The present invention relates to one kind of method suitable for super micro crushing of Chinese medicinal material. Vibrating mill with vibrating mill barrel lining grinding body of high-strength ceramic material is used as the super micro crusher. Before and / or during super micro crushing, the crushed material is freeze treated and / or the NO2 or dry ice as cooling agent is used to cool heating grinding parts. The method of the present invention is suitable for continuous industrial super micro crushing production of heat-sensitive biological material, such as Chinese medicinal material. The crushed Chinese medicinal material has granularity of 0.09-1.5 micron and no pollutant heavy metal detected, and the material temperature during super micro crushing is below 10 deg.c.

Description

technical field [0001] The invention relates to a method suitable for ultrafine pulverization of Chinese medicinal materials. Background technique [0002] The ultrafine particle crushing of traditional Chinese medicinal materials is a hot topic in the international modern manufacturing technology of traditional Chinese medicine. Mechanical equipment used in this field, such as ultra-fine grinding, micro-grinding, ultra-micro-grinding and other devices came into being, through strong extrusion, shearing, impact, impact, collision, grinding, friction, cutting rubbing, cavitation explosion, Mechanical pulverization such as turbulence can achieve the purpose of ultrafine pulverization of materials, but at the same time it also causes the materials to undergo ultrafine pulverization during the process of ultrafine pulverization such as metal material impact and grinding parts, impact, collision, grinding, cutting, rubbing, and friction. Heat generation, reduce mechanical proper...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B02C19/16A61J3/02
Inventor 刘昕吴佳扬
Owner SUN YAT SEN UNIV