Prepn. of water soluble chitosan with controllable molecular weight

A technology for water-soluble chitosan and chitosan, which is applied in the field of preparation of water-soluble chitosan with controllable molecular weight, can solve the problems of high viscosity and difficult to control, and achieves no by-products, good biocompatibility, reaction Effects with easily controlled conditions

Inactive Publication Date: 2003-01-08
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent 00114484.7 has introduced a kind of method that high-concentration hydrogen peroxide prepares oligomeric water-soluble chitosan, and this patent mentions under the action of hydrogen peroxide of 20-50% by

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0011] Example 1:

[0012] Implementation of chitosan with 54% deacetylation degree and 0.05 mol / L sodium hypochlorite-0.1 mol / L hydrogen peroxide.

[0013] Weigh 2g of chitosan with 54% deacetylation degree, grind, dissolve in hydrochloric acid solution, stir well, slowly add 10ml of 0.05mol / L sodium hypochlorite, stir for 1 hour, then add 5ml 0.1mol / L peroxide dropwise Hydrogen solution, react at room temperature for 8 hours. After the completion of the reaction, the reaction solution was filtered, the filtrate was concentrated under vacuum for 24 hours, and then the concentrated solution was poured into methanol to fully precipitate, and a light yellow product was obtained after filtration and drying.

Example Embodiment

[0014] Example 2:

[0015] Implementation of chitosan with a degree of deacetylation of 78% and 0.05 mole / liter sodium hypochlorite-1.0 mole / liter hydrogen peroxide.

[0016] Weigh 2g of chitosan with a degree of deacetylation of 78%, grind it, dissolve it in hydrochloric acid solution, stir well, slowly add 10ml of 0.05mol / L sodium hypochlorite, stir for 1 hour, and then add 5ml 1.0mol / L peroxide dropwise Hydrogen solution, react at room temperature for 4 hours. After the completion of the reaction, the reaction solution was filtered, the filtrate was concentrated under vacuum for 24 hours, and then the concentrated solution was poured into methanol to fully precipitate, and a light yellow product was obtained after filtration and drying.

Example Embodiment

[0017] Example 3:

[0018] Implementation of chitosan with a degree of deacetylation of 92% and 0.1 mol / L sodium hypochlorite-2.0 mol / L hydrogen peroxide.

[0019] Weigh 2 g of chitosan with a degree of deacetylation of 92%, grind it, dissolve it in a hydrochloric acid solution, stir well, slowly add 6 ml of 0.1 mol / L sodium hypochlorite, stir for 1 hour, and then add 5 ml of 2.0 mol / L peroxide dropwise Hydrogen solution, react at room temperature for 4 hours. After the completion of the reaction, the reaction solution was filtered, the filtrate was concentrated under vacuum for 24 hours, and the concentrated solution was poured into methanol to fully precipitate it, and a white product was obtained after filtration and drying.

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Abstract

There is a method of preparing the controlled molecular weight, water-soluble shell glycan, which fully dissolve all kinds of non-acetyl shell glycans into the hydrochloric acid, then slowly add the oxidant-sodium hypochlorite-hydrogen peroxide to the solution, then make them react under the room temperature to break away the 1,4-beta-D-indican bond, and produce the low molecular weight, water-soluble shell glycan. The invention's process is simple, and the prepared low molecular weight, water-soluble shell glycan had good water solubility and retains the main-chain structure of the shell glycan, and can be used as not only the materials of oral medicines and health products, but also the additive of the cosmetics and the food trades.

Description

Technical field: [0001] The invention relates to a method for preparing water-soluble chitosan with controllable molecular weight. The obtained product has unique water-solubility, can expand the processing range of original chitosan, and can be used not only as an additive in cosmetics and food industries, but also as a Raw materials for oral medicines and health products, or processed into other related biological products. Background technique: [0002] Chitin is a straight-chain polysaccharide in which N-acetyl-D-glucose is linked by β(1→4) glycosidic bonds, and it is very abundant in nature. Chitosan obtained by deacetylation of chitin usually has a molecular weight of about one million and has a compact crystal structure. It is insoluble in common solvents and only soluble in some acidic media, which severely limits its use in medicine, food, and cosmetics. and many other applications. If appropriate methods are used to degrade it to an average molecular weight of ~1...

Claims

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Application Information

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IPC IPC(8): C08B37/08
Inventor 田丰胡克鳌
Owner SHANGHAI JIAO TONG UNIV
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