Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Prepn. of water soluble chitosan with controllable molecular weight

A technology for water-soluble chitosan and chitosan, which is applied in the field of preparation of water-soluble chitosan with controllable molecular weight, can solve the problems of high viscosity and difficult to control, and achieves no by-products, good biocompatibility, reaction Effects with easily controlled conditions

Inactive Publication Date: 2003-01-08
SHANGHAI JIAO TONG UNIV
View PDF1 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese patent 00114484.7 has introduced a kind of method that high-concentration hydrogen peroxide prepares oligomeric water-soluble chitosan, and this patent mentions under the action of hydrogen peroxide of 20-50% by weight concentration, can react at 60-90 ℃ To obtain oligomeric water-soluble chitosan, a large number of foams are produced in the reaction, and a sticky liquid appears, the viscosity is high, and it is difficult to control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Implementation of chitosan with 54% degree of deacetylation and 0.05 mol / liter sodium hypochlorite-0.1 mol / liter hydrogen peroxide.

[0013] Weigh 2 grams of chitosan with a degree of deacetylation of 54%, grind, dissolve in hydrochloric acid solution, stir well, slowly add 10 ml of 0.05 mol / liter sodium hypochlorite, stir for 1 hour, then add 5 ml of 0.1 mol / liter peroxide dropwise Hydrogen solution, reacted at room temperature for 8 hours. After the reaction was completed, the reaction liquid was filtered, and the filtrate was concentrated under vacuum for 24 hours, and then the concentrated liquid was poured into methanol for sufficient precipitation, and a light yellow product was obtained after filtration and drying.

Embodiment 2

[0015] Implementation of chitosan with a deacetylation degree of 78% and 0.05 mol / liter sodium hypochlorite-1.0 mol / liter hydrogen peroxide.

[0016] Weigh 2 grams of chitosan with a degree of deacetylation of 78%, grind, dissolve in hydrochloric acid solution, stir well, slowly add 10 ml of 0.05 mol / L sodium hypochlorite, stir for 1 hour, then add 5 ml of 1.0 mol / L peroxide dropwise Hydrogen solution, reacted at room temperature for 4 hours. After the reaction was completed, the reaction liquid was filtered, and the filtrate was concentrated under vacuum for 24 hours, and then the concentrated liquid was poured into methanol for sufficient precipitation, and a light yellow product was obtained after filtration and drying.

Embodiment 3

[0018] Implementation of chitosan with a deacetylation degree of 92% and 0.1 mol / liter sodium hypochlorite-2.0 mol / liter hydrogen peroxide.

[0019] Weigh 2 grams of chitosan with a degree of deacetylation of 92%, grind, dissolve in hydrochloric acid solution, stir well, slowly add 0.1 mol / L sodium hypochlorite 6ml, stir for 1 hour, then add 5ml 2.0 mol / L peroxide dropwise Hydrogen solution, reacted at room temperature for 4 hours. After the reaction, the reaction liquid was filtered, and the filtrate was concentrated under vacuum for 24 hours, and then the concentrated liquid was poured into methanol for sufficient precipitation, and a white product was obtained after filtration and drying.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

There is a method of preparing the controlled molecular weight, water-soluble shell glycan, which fully dissolve all kinds of non-acetyl shell glycans into the hydrochloric acid, then slowly add the oxidant-sodium hypochlorite-hydrogen peroxide to the solution, then make them react under the room temperature to break away the 1,4-beta-D-indican bond, and produce the low molecular weight, water-soluble shell glycan. The invention's process is simple, and the prepared low molecular weight, water-soluble shell glycan had good water solubility and retains the main-chain structure of the shell glycan, and can be used as not only the materials of oral medicines and health products, but also the additive of the cosmetics and the food trades.

Description

Technical field: [0001] The invention relates to a method for preparing water-soluble chitosan with controllable molecular weight. The obtained product has unique water-solubility, can expand the processing range of original chitosan, and can be used not only as an additive in cosmetics and food industries, but also as a Raw materials for oral medicines and health products, or processed into other related biological products. Background technique: [0002] Chitin is a straight-chain polysaccharide in which N-acetyl-D-glucose is linked by β(1→4) glycosidic bonds, and it is very abundant in nature. Chitosan obtained by deacetylation of chitin usually has a molecular weight of about one million and has a compact crystal structure. It is insoluble in common solvents and only soluble in some acidic media, which severely limits its use in medicine, food, and cosmetics. and many other applications. If appropriate methods are used to degrade it to an average molecular weight of ~1...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08B37/08
Inventor 田丰胡克鳌
Owner SHANGHAI JIAO TONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com