A kind of silicon calcium phosphate nanopowder, preparation method and application

Abstract

The invention relates to a silicon calcium phosphate nanopowder, a preparation method and an application. The preparation method includes: mixing the calcium source with the first liquid phase dispersant to prepare a calcium source dispersion system, then adding the silicon source dropwise, and dispersing evenly to obtain a calcium-silicon mixed liquid; mixing the phosphorus source with the second liquid phase dispersant , to be prepared into a phosphorus source dispersion system; the phosphorus source dispersion system is added dropwise to the calcium-silicon mixed solution, and the mixed system containing the calcium-silicon mixed solution and the phosphorus source dispersion system is ultrasonically treated during the dropping process, and the addition ends Afterwards, ultrasonic treatment is continued; the mixed system after ultrasonic treatment is filtered, washed, and dried to obtain a silicon calcium phosphate precursor; the silicon calcium phosphate precursor is calcined to obtain silicon calcium phosphate nanopowder. The silicon calcium phosphate nanometer powder obtained by the method has high purity, nanoscale particle size, low degree of agglomeration, good dispersion, low calcining temperature, cheap raw materials, simple operation, no by-products, and easy industrial production.

Description

technical field

[0001] The invention relates to the technical field of medical biomaterials, in particular to a silicon calcium phosphate nanopowder, a preparation method and an application. Background technique

[0002] In recent years, the biomedical material market in China and the world has shown an exponential growth trend. As an important part of biomedical materials, bone repair materials have a considerable market. Currently, the commonly used bone repair materials mainly include autologous bone, allogeneic bone and artificial materials. Although these materials have been applied clinically, they still have certain limitations. The development of bone repair materials with excellent performance is still an important topic in the field of biomedical materials, which has great social significance and huge economic benefits.

[0003] At present, inorganic materials for hard tissue repair mainly include bioceramics, bioglass and their composite materials. Phosphate bio...

Examples

preparation example Construction

[0047] The invention provides a preparation method of silicon calcium phosphate nanopowder, comprising the following steps:

[0048] (1) The calcium source is mixed with the first liquid phase dispersant to prepare a calcium source dispersion system, and then the silicon source is added dropwise to disperse evenly to obtain a calcium-silicon mixed liquid.

[0049]In this step, the calcium source is any one or more of easily soluble, soluble or slightly soluble calcium sources, for example, any one of calcium nitrate, calcium chloride, calcium phosphate, and calcium hydroxide can be selected. or more, preferably calcium hydroxide; the silicon source can be selected from commonly used silicon source reagents, more suitable are ethyl orthosilicate, silica sol, sodium silicate, calcium silicate, and the above-mentioned Any one or more of the silicon source reagents is preferably ethyl orthosilicate.

[0050] It should be noted that the above-mentioned easily soluble, soluble, and...

Embodiment 1

[0082] (1) Prepare Ca(OH) with a concentration of 0.5mol / L 2 Solution 500mL. Weigh 18.53 g of analytically pure calcium hydroxide powder into a beaker, add deionized water until the total volume of the solution is 500 mL, place the beaker in an ultrasonic device for full-power ultrasonication with mechanical stirring for 30 min, and obtain a highly dispersed suspension.

[0083] (2) Prepare H with a concentration of 0.2mol / L 3 PO 4 Solution 500mL. Measure 6.8mL of analytically pure H 3 PO 4 , diluted with deionized water to a total volume of 500mL, placed in an ultrasonic device and ultrasonically mixed evenly.

[0084] (3) Measure 11.2 mL of analytically pure tetraethyl orthosilicate (TEOS) and add it dropwise to Ca(OH) 2 The suspension was placed in an ultrasonic device for continuous ultrasonication and mechanical stirring for 1 hour to obtain a calcium-silicon mixture.

[0085] (4) After step (3), the H 3 PO 4 The solution was slowly added dropwise into the calciu...

Embodiment 2

[0089] (1) With embodiment 1.

[0090] (2) With embodiment 1.

[0091] (3) with embodiment 1.

[0092] (4) After step (3), the H 3 PO 4 The solution was slowly added dropwise into the calcium and silicon mixed solution with a separatory funnel, and the mixed system was ultrasonically treated during the dropping process (H 3 PO 4 The solution dripping process lasted 27±2min), and continued ultrasonic treatment after the addition, wherein the ultrasonic power was 350W, the ultrasonic frequency was 53kHz, the total duration of ultrasonic treatment was 60min, and the temperature of the mixing system was maintained at 40-60°C. At the same time, ammonia water is used to control the pH of the solution between 10 and 11 without aging time.

[0093] (5) with embodiment 1.

[0094] (6) With embodiment 1.

technical field

[0001] The invention relates to the technical field of medical biomaterials, in particular to a silicon calcium phosphate nanopowder, a preparation method and an application. Background technique

[0002] In recent years, the biomedical material market in China and the world has shown an exponential growth trend. As an important part of biomedical materials, bone repair materials have a considerable market. Currently, the commonly used bone repair materials mainly include autologous bone, allogeneic bone and artificial materials. Although these materials have been applied clinically, they still have certain limitations. The development of bone repair materials with excellent performance is still an important topic in the field of biomedical materials, which has great social significance and huge economic benefits.

[0003] At present, inorganic materials for hard tissue repair mainly include bioceramics, bioglass and their composite materials. Phosphate bio...

Examples

preparation example Construction

[0047] The invention provides a preparation method of silicon calcium phosphate nanopowder, comprising the following steps:

[0048] (1) The calcium source is mixed with the first liquid phase dispersant to prepare a calcium source dispersion system, and then the silicon source is added dropwise to disperse evenly to obtain a calcium-silicon mixed liquid.

[0049]In this step, the calcium source is any one or more of easily soluble, soluble or slightly soluble calcium sources, for example, any one of calcium nitrate, calcium chloride, calcium phosphate, and calcium hydroxide can be selected. or more, preferably calcium hydroxide; the silicon source can be selected from commonly used silicon source reagents, more suitable are ethyl orthosilicate, silica sol, sodium silicate, calcium silicate, and the above-mentioned Any one or more of the silicon source reagents is preferably ethyl orthosilicate.

[0050] It should be noted that the above-mentioned easily soluble, soluble, and...

Embodiment 1

[0082] (1) Prepare Ca(OH) with a concentration of 0.5mol / L 2 Solution 500mL. Weigh 18.53 g of analytically pure calcium hydroxide powder into a beaker, add deionized water until the total volume of the solution is 500 mL, place the beaker in an ultrasonic device for full-power ultrasonication with mechanical stirring for 30 min, and obtain a highly dispersed suspension.

[0083] (2) Prepare H with a concentration of 0.2mol / L 3 PO 4 Solution 500mL. Measure 6.8mL of analytically pure H 3 PO 4 , diluted with deionized water to a total volume of 500mL, placed in an ultrasonic device and ultrasonically mixed evenly.

[0084] (3) Measure 11.2 mL of analytically pure tetraethyl orthosilicate (TEOS) and add it dropwise to Ca(OH) 2 The suspension was placed in an ultrasonic device for continuous ultrasonication and mechanical stirring for 1 hour to obtain a calcium-silicon mixture.

[0085] (4) After step (3), the H 3 PO 4 The solution was slowly added dropwise into the calciu...

Embodiment 2

[0089] (1) With embodiment 1.

[0090] (2) With embodiment 1.

[0091] (3) with embodiment 1.

[0092] (4) After step (3), the H 3 PO 4 The solution was slowly added dropwise into the calcium and silicon mixed solution with a separatory funnel, and the mixed system was ultrasonically treated during the dropping process (H 3 PO 4 The solution dripping process lasted 27±2min), and continued ultrasonic treatment after the addition, wherein the ultrasonic power was 350W, the ultrasonic frequency was 53kHz, the total duration of ultrasonic treatment was 60min, and the temperature of the mixing system was maintained at 40-60°C. At the same time, ammonia water is used to control the pH of the solution between 10 and 11 without aging time.

[0093] (5) with embodiment 1.

[0094] (6) With embodiment 1.

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