Porous material for scaffold of tissue engineering and its preparing process

Abstract

A porous material used as the scaffold in tissue engineering is prepared from the sericine and silk extract extracted from the silk of silkworm or tussah through proportionally mixing, fast stirring at a certain temp. freeze drying to shape porous block or membrane, and injecting the slowly-releasing microgel of cell growth factor into the pores. Its advantages are high biocompatibility and adjustable biodegradation speed.

Description

technical field

[0001] The invention belongs to the field of biomedical materials, in particular to a porous material suitable for tissue engineering scaffolds and a preparation method thereof. Background technique

[0002] At present, biodegradable porous materials for tissue engineering have been developed, mainly including polylactic acid (PLA), polyglycolic acid (PGA), and collagen. However, synthetic materials (PLA, PGA, etc.) still have many problems in biocompatibility, physicochemical properties, control of degradation rate and sustained release, and the synthesis process is complicated. Collagen in natural material itself contains a lot of biological information, which can enable cells to maintain or produce many functions, but the purification of specific types of collagen is cumbersome, quality control is more difficult, and whether the influence of antigens and diseases can be completely avoided. The spread remains to be seen.

[0003] Studi...