In-situ detection of product quality index in Chinese medicine production process

A production process and product quality technology, applied in the direction of measuring device, color/spectral characteristic measurement, material analysis through optical means, etc., can solve the problems of insurmountable quality control, no online detection, etc., to improve uniformity and stability , Eliminate blind spots, improve the effect of quality control

Inactive Publication Date: 2003-03-19
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, in the production process of traditional Chinese medicine, especially the extraction and separation process, there is basically no online detection method, resulting in an insurmountable blind spot in quality control

Method used

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  • In-situ detection of product quality index in Chinese medicine production process
  • In-situ detection of product quality index in Chinese medicine production process
  • In-situ detection of product quality index in Chinese medicine production process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] see figure 1 , is the process flow chart of Chinese medicine extraction, which is carried out according to different process routes according to different Chinese medicine varieties. The general extraction process of traditional Chinese medicine includes extraction, solid-liquid separation, concentration, refining, and drying.

[0017] 1. During extraction, an extraction medium selected from the following is included: water, ethanol, wine, petroleum ether, ether, chloroform, acetone, fatty oil, carbon dioxide, ethylene, and nitrous oxide.

[0018] 2. Including an extraction aid selected from the following during extraction: acid, alkali, glycerin, surfactant, methanol, ethanol, isopropanol, ammonia, and low-boiling alkanes.

[0019] 3. Wherein said extraction comprises a method selected from the following: cold soaking, warm soaking, percolation, decoction, reflux, distillation, pressure leaching, decompression leaching, ultrasonic extraction, microwave Extraction met...

Embodiment 2

[0028] see figure 2 , is a schematic diagram for on-line measurement in the present invention. In a typical production process of traditional Chinese medicine, the Chinese medicine extract at each time point produced in each process is measured by near-infrared. In an embodiment of the present invention, the spectrometer used is a Fourier transform near-infrared spectrometer, which is a spectrometer designed to measure the near-infrared region, and the output of the spectrometer is the absorption spectrum of the Chinese medicine extract at each time point of the measured process. Spectral data, and for computer adoption.

[0029] 1. Obtain a group of near-infrared measurement spectra and quality index values ​​of a group of calibration samples of at least one intermediate step in the process.

[0030] 2. Spectral preprocessing: first-order differential, second-order differential, vector normalization, straight-line subtraction, minimum-maximum normalization, multiple scatter...

Embodiment 3

[0036] Example 3: On-line detection of macroporous resin separation process in Chinese medicine industry

[0037] Taking the content of multiple alkaloids in Coptidis Rhizome as the investigation index, using high performance liquid chromatography as the standard control method, the index value of the calibration sample was obtained. The correlation model between the near-infrared spectrum and the concentration of Coptidis alkaloids was established by the square algorithm, and the elution curve of Coptidis alkaloids in macroporous resin chromatography was predicted by this. The method of the present invention can simultaneously determine the content of multiple alkaloids in the eluate, and the detection process of each sample can be completed in only 30 seconds, and the prediction accuracy meets the requirements. For the results, see image 3 , Figure 4 .

[0038] step:

[0039] 1. Collect eluent calibration samples at different elution time points.

[0040] 2. Use RP-HPL...

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Abstract

The present invention provides the in-situ detection of product quality index in Chinese medicine production process and relates to one Chinese medicine producing shop, where relevant technological parameters and quality indexex are in-situ detected directly. The shop is equipped with in-situ detection system, which needs no any sample from the technological process. The system is equipped with one near infrared spectrometer and one industrial control comdputer and its in-situ real-time analysis system adopting least-square method and neural network method can be used in predicting the quality indexes in the production and providing analysis data. The method may be used in different Chinese medicine production shops.

Description

technical field [0001] The invention belongs to product quality detection, and relates to product quality detection in a traditional Chinese medicine production process, in particular to a method for on-line detection of quality indicators in a traditional Chinese medicine extraction workshop in the extraction and separation process of traditional Chinese medicine. Background technique [0002] The current quality control mode of traditional Chinese medicine generally selects a certain index component or active ingredient of traditional Chinese medicine, establishes simple physical and chemical identification, spectral, chromatographic identification, and content determination methods to control the quality of traditional Chinese medicine, and the objects of control are generally limited to Chinese medicinal materials and the production process of traditional Chinese medicine. There is no effective control over the quality changes of Chinese medicine extracts during the produ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N35/00
Inventor 程翼宇瞿海斌吴永江邵青栾连军赵宜军
Owner ZHEJIANG UNIV
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