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Chemical process of preparing bioactive hydroxy apatite layer on the surface of NiTi alloy

A technology of hydroxyapatite and biological activity, which is applied in metal material coating technology, coating, medical science, etc., can solve the problems of affecting clinical use effect, destroying shape memory effect, low matrix binding force, etc., and achieving nickel ion Dissolution problem control, bone growth induction, high bonding strength effect

Inactive Publication Date: 2003-05-14
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The coatings prepared by these methods are all formed at high temperature, hydroxyapatite is amorphous, easy to dissolve, and has low binding force with the substrate
At the same time, the high-temperature environment of the process will cause a phase change in the substrate, destroying the shape memory effect, and retraining will inevitably cause the coating to peel off, affecting the clinical use effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] 1) A bulk NiTi alloy of 10×10×3mm was selected for the experiment, and the atomic percentage of Ni and Ti was about 1:1.

[0009] 2) Sand the sample from 150 # -400 # Polish in sequence, ultrasonically clean with acetone for about 10 minutes, then clean with deionized water and dry.

[0010] 3) Acid treatment: immerse the cleaned sample in 1:1 ratio of HCl (36%), H 2 SO 4 (95%) in the mixed liquid solution, etched at a constant temperature of 60°C for 25 minutes, then taken out, cleaned by ultrasonic waves, and dried at 40°C.

[0011] 4) Alkali treatment: the acid-treated sample was placed in a condensation reflux device, heated and boiled with 2M NaOH solution for 5 hours, and the volume of NaOH was kept constant during the whole process. The samples after alkali boiling were ultrasonically cleaned with deionized water.

[0012] 5) Pre-calcification treatment: put the above sample into saturated Na 2 HPO 4 In the solution, keep the temperature at 40°C for 15 hou...

Embodiment 2

[0016] 1) A bulk NiTi alloy of 10×10×3mm was selected for the experiment, and the atomic percentage of Ni and Ti was about 1:1.

[0017] 2) Sand the sample from 150 # -400 # Polish in sequence, ultrasonically clean with acetone for about 10 minutes, then clean with deionized water and dry.

[0018] 3) Acid treatment: immerse the cleaned sample in HNO 3 (40%) aqueous solution, eroded at a constant temperature of 60°C for 20h, taken out, cleaned by ultrasonic waves, and dried at 40°C.

[0019] 4) Alkali treatment: the acid-treated sample was placed in a condensation reflux device, heated and boiled with 1.2M NaOH aqueous solution for 5 hours, and the volume of NaOH was kept constant during the whole process. The samples after alkali boiling were ultrasonically cleaned with deionized water.

[0020] 5) Pre-calcification treatment: put the above sample into saturated Na 2 HPO 4 In the solution, keep the temperature at 40°C for 15 hours, take it out, wash it, and place it in ...

Embodiment 3

[0024] 1) A bulk NiTi alloy of 10×10×3mm was selected for the experiment, and the atomic percentage of Ni and Ti was about 1:1.

[0025] 2) Sand the sample from 150 # -400 # Polish in sequence, ultrasonically clean with acetone for about 10 minutes, then clean with deionized water and dry.

[0026] 3) Acid treatment: immerse the cleaned sample in HNO 3 (52%) in an aqueous solution, etched at a constant temperature of 60°C for 20 hours, taken out, ultrasonically cleaned, and dried at 40°C.

[0027] 4) Alkali treatment: Soak the acid-treated sample in 1.0M NaOH aqueous solution, treat it at a constant temperature of 60°C for 24 hours, take it out, and dry it at 40°C after ultrasonic cleaning.

[0028] 5) Pre-calcification treatment: put the above sample into saturated Na 2 HPO 4 In the solution, keep the temperature at 40°C for 15 hours, take it out, wash it, and place it in saturated Ca(OH) 2 Solution, soak at room temperature for 10 hours, take out and wash.

[0029] 6)...

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PUM

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Abstract

The present invention discloses a chemical process of preparing bioactive hydroxyapatite layer on the surface of NiTi alloy. The NiTi alloy matrix is first polished, cleaned and dried; then acid and alkali treated, dried and precalcified in Na2HOP4 and Ca(OH)2 solution; and finally processed in simulating body fluid to grow hydroxyapatite naturally. The present invention is characterized by the said treating liquid, which is mixed acid of HCl, H2SO4 and H2O in the ratio of 1 to 1 to 0-4 30-65 % concentration HNO3 water solution and used in treatment at 20-60 deg.c for 1-24 hr; and the alkali solution of 1-5 M concentration sodium hydroxide solution at 40-150 deg.c used in soaking for 1-24 hr. The present invention has the advantages of low acid and alkali treating temperature, matrix withshape memory effect and surface bioactivity and capable of being implanted into body to induce the formation of hydroxyapatite, etc.

Description

technical field [0001] The invention relates to a method for activating the surface of a NiTi shape memory alloy through chemical treatment to rapidly grow a hydroxyapatite bioactive layer in simulated body fluid. The invention belongs to the technology of preparing bioactive layer on the surface of NiTi alloy. Background technique [0002] Hydroxyapatite (HA) has good biocompatibility. If HA can be coated on the surface of NiTi shape memory alloy, it can give full play to the excellent mechanical properties of metal and the unique biocompatibility of ceramics. , to make human hard tissue replacement and repair materials that can meet clinical applications. At present, the common methods for forming hydroxyapatite on the surface of NiTi alloy are plasma spraying method and laser melting coating method. The coatings prepared by these methods are all formed at high temperature, and the hydroxyapatite is amorphous, easy to dissolve, and has low...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/32C23C22/00
Inventor 杨贤金崔振铎陈民芳朱胜利
Owner TIANJIN UNIV
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