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Freeze-dried powder injection for curing hepatitis, large dise transfusion medicine and its preparation method

A freeze-dried powder injection and anti-hepatitis technology, which can be used in freeze-dried delivery, powder delivery, drug delivery, etc., can solve the problems of petridine base being unstable when exposed to light, inconvenient to carry, transport and store, and affect drug stability, etc., to achieve effective Benefits of long-term storage, shorter treatment time, good market prospects and social benefits

Inactive Publication Date: 2003-12-10
陕西天森药物研究开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, the anti-hepatitis Yanhuanglian injection small injection made of the traditional Chinese medicine Yanhuanglian as the main component is injected intramuscularly, and the therapeutic effect is relatively slow. In addition, there are the following deficiencies. First, it is inconvenient to use. It is necessary to break the ampoule first, which will inevitably cause the ampoule bottle to fall into pieces more or less; secondly, it needs to be given local high temperature during its production and sealing, which will inevitably affect the stability of the drug; The third is that the main component of the drug, petrizine, is unstable when exposed to light, and the drug in the small injection is highly dispersed to increase the photosensitive surface, which makes the drug easy to deteriorate and unstable; the fourth small injection ampoule is fragile and fragile, and it is inconvenient to carry, transport and store

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: Preparation of anti-hepatitis drug freeze-dried powder injection

[0016] Methods include:

[0017] Grind rhizoma rhizome into coarse powder, weigh the coarse powder, soak with 5 times the amount of 90% ethanol for 24 hours, reflux extraction 4 times, each time for 1 hour, combine the extracts, recover ethanol under reduced pressure and concentrate to a relative density of 0.92- The clear paste of 1.02 is allowed to cool, filtered, and the filtrate is concentrated to a thick paste with a relative density of 1.16-1.20. Add distilled water to the thick paste, precipitate brown precipitated water, adjust the pH value to 2-3 with 10% hydrochloric acid solution, stir well, filter, wash 4-5 times with 10% hydrochloric acid solution, combine acid water, sodium carbonate Adjust the pH value to 9-10, precipitate a tan precipitate, filter, and extract the filter residue with 5 times the amount of chloroform for 5-6 times, combine the chloroform solution, add anhydr...

Embodiment 2

[0018] Embodiment 2: preparation anti-hepatitis drug big infusion

[0019] Methods include:

[0020] Grind rhizoma rhizome into coarse powder, weigh the coarse powder, soak with 5 times the amount of 90% ethanol for 24 hours, reflux extraction 4 times, each time for 1 hour, combine the extracts, recover ethanol under reduced pressure and concentrate to a relative density of 0.92- The clear paste of 1.02 is allowed to cool, filtered, and the filtrate is concentrated to a thick paste with a relative density of 1.16-1.20. Add distilled water to the thick paste, precipitate brown precipitated water, adjust the pH value to 2-3 with 10% hydrochloric acid solution, stir well, filter, wash 4-5 times with 10% hydrochloric acid solution, combine acid water, sodium carbonate Adjust the pH value to 9-10, precipitate a tan precipitate, filter, and extract the filter residue with 5 times the amount of chloroform for 5-6 times, combine the chloroform solution, add anhydrous sodium sulfate f...

Embodiment 3

[0021] Embodiment 3: Preparation of anti-hepatitis drug freeze-dried powder injection composition

[0022] According to the weight ratio, it contains 1 part of active ingredient of rhizome and 185 parts of auxiliary materials. Wherein the solubilizer polybehenate 10 parts, polyethylene glycol 5 parts. Filler lactose 30 parts, mannitol 140 parts.

[0023] The method for preparing this medicine freeze-dried powder injection:

[0024] Grind rhizoma rhizome into coarse powder, weigh the coarse powder, soak with 5 times the amount of 90% ethanol for 24 hours, reflux extraction 4 times, each time for 1 hour, combine the extracts, recover ethanol under reduced pressure and concentrate to a relative density of 0.92- The clear paste of 1.02 is allowed to cool, filtered, and the filtrate is concentrated to a thick paste with a relative density of 1.16-1.20. Add distilled water to the thick paste, precipitate brown precipitated water, adjust the pH value to 2-3 with 10% hydrochloric a...

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Abstract

The present invention relates to a kind of freeze-dried powder injection for curing hepatitis, its medicine composition for fluid infusion and their preparation method. The freeze-dried powder injection composition contains 1 portion of effective component extracted from root of meadowrueleaf corydalis and 50-500 portions of auxiliary material, and the medicine composition for fluid infusion contains 1 portion of effective component of root of meadowrueleaf corydalis and 800-1000 portions of auxiliary material, and their preparation method includes the following steps: decocting root of meadowrueleaf corydalis, separating and purifying to obtain its extract, mixing it with auxiliary material uniformly, dissolving them in injection water, filtering, filling and sterilizing so as to obtain the invented product.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition of freeze-dried powder injection and large transfusion of anti-hepatitis drugs and a preparation method thereof, and is especially suitable for preparing the pharmaceutical composition of freeze-dried powder injection and large transfusion by using the purified product of Chinese herbal medicine Yanhuanglian method. 2. Background technology [0002] At present, the anti-hepatitis Yanhuanglian injection small injection made of the traditional Chinese medicine Yanhuanglian as the main component is injected intramuscularly, and the therapeutic effect is relatively slow. In addition, there are the following deficiencies. First, it is inconvenient to use. It is necessary to break the ampoule first, which will inevitably cause the ampoule bottle to fall into pieces more or less; secondly, it needs to be given local high temperature during its production and sealing, which will inevitably affect the sta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61P1/16A61P31/12
Inventor 毛幼桦
Owner 陕西天森药物研究开发有限公司
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