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Recombination alpha-interferon gelatin injection

A technology of gel propellant and interferon, which is applied in the direction of antiviral agents, drug combinations, peptide/protein components, etc., can solve the problems of clothing contaminated by dissolved effluent and inconvenient vaginal medication, and achieve safe and non-toxic use. Negative effect, long shelf life effect

Inactive Publication Date: 2004-01-14
SHENYANG SUNSHINE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the interferon preparations that have been marketed for the treatment of gynecological viral inflammation are suppositories, using gelatin-glycerin base or fat-soluble base, which is not very convenient for vaginal administration, and the dissolved effluent contaminates clothes

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Ingredient content (weight%)

[0025] Carbomer 934 0.5%

[0026] 10% Sodium Hydroxide 2%

[0027] Methylparaben 0.2%

[0028] Recombinant Human Alpha Interferon 333,000 IU / g

[0029] Water make up 100%

[0030] Take water, add methyl p-hydroxybenzoate, add carbomer after dissolving, add sodium hydroxide solution after dissolving, neutralize, and form a gel. Add recombinant human α-interferon, mix well, and fill in a syringe.

Embodiment 2

[0032] Ingredient content (weight%)

[0033] Carbomer 934 0.5%

[0034] 10% Sodium Hydroxide 2%

[0035] Methylparaben 0.18%

[0036] Propylparaben 0.02%

[0037] Glycerin 10%

[0038] Disodium edetate 0.02%

[0039] Recombinant Human Alpha Interferon 10,000 IU / g

[0040] Water make up 100%

[0041] Take water, add glycerin, add methyl p-hydroxybenzoate and propyl p-hydroxybenzoate after dissolving, add disodium edetate after dissolving, add carbomer after dissolving, add sodium hydroxide solution after dissolving, and, to form a gel. Add recombinant human α-interferon, mix well, and fill in a syringe.

Embodiment 3

[0043] Ingredient content (weight%)

[0044] Carbomer 940 0.5%

[0045] 10% Sodium Hydroxide 2%

[0046] Methylparaben 0.2%

[0047] Ethanol 10%

[0048] Sodium thiosulfate 0.02%

[0049] Recombinant Human Alpha Interferon 100,000 IU / g

[0050] Water make up 100%

[0051] Take water, add ethanol, add methyl p-hydroxybenzoate after dissolving, add sodium thiosulfate after dissolving, add carbomer after dissolving, add sodium hydroxide solution after dissolving, neutralize, and form a gel. Add recombinant human α-interferon, mix well, and fill in a syringe.

[0052] The recombinant human alpha interferon of the above-mentioned example 1-3 is stable at 2~8°C,

[0053] Interferon activity (×10 5 IU / g)

[0054] Conclusion: The interferon activity remains unchanged within 15 months of storage at 2-8°C; the long-term investigation is still in progress.

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PUM

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Abstract

A recombinant human alpha-interferon gel in the injection for treating the viral vagina diseases of woman contains the recombinant human alpha-interferon as active component, the carbomer as the gel matrix, the antiseptic compatible with interferon, the sodium hydroxide or triethanolamine as neutralizer of carbomer, and water. Its advantages are no irritation and pollution to clothes, and no any by-effect.

Description

technical field [0001] The invention relates to a recombinant human alpha interferon gel propellant for treating gynecological diseases. Interferon is an important cell activity factor, which has biological activities such as anti-virus, immune regulation, hormone-like activity, and anti-tumor. Clinically, it has been widely used in antiviral infection, treatment of tumors and activation of immune cells to play an immune mediation role. Background technique [0002] Chronic cervicitis (cervical erosion) caused by herpes simplex virus and human papillomavirus is a common disease in gynecology, and it is the most common inflammation of the female reproductive system. At present, the interferon preparations that have been marketed for the treatment of gynecological viral inflammation are suppositories, which use gelatin-glycerin base or fat-soluble base, which is not very convenient for vaginal administration, and the dissolved effluent contaminates clothes. Using gelatin-gly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K38/21A61P15/02A61P31/12
Inventor 赵会林侯绪凤苏冬梅
Owner SHENYANG SUNSHINE PHARMA
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