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Slow and control release aspirin capsule formulation and method for making same

A technology of aspirin and capsules, which is applied in the field of aspirin sustained and controlled release capsule preparations and its preparation, can solve the problems of large impact, aggravated side effects, unstable blood drug concentration, etc., and achieve the effect of improving curative effect and reducing side effects

Inactive Publication Date: 2004-08-25
TIANJIN PACIFIC PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Aspirin enteric-coated tablets have been produced and sold to reduce gastric irritation, but the tablets are greatly affected by the gastric pyloric sphincter. It has been reported that the time from the stomach to the small intestine is 15 minutes to 7 hours, resulting in a very low blood concentration. Stable, and it is easy to cause excessive local concentration in the small intestine, aggravating side effects

Method used

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  • Slow and control release aspirin capsule formulation and method for making same
  • Slow and control release aspirin capsule formulation and method for making same
  • Slow and control release aspirin capsule formulation and method for making same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the preparation of ball core

[0036] The ball core used in the present invention can adopt commercially available blank ball core, also can adopt telecentric type coating machine, fluidized bed coating machine or the water chestnut type sugar-coated pan after transformation to prepare by oneself by following prescription. The preferred diameter is 450μm-780μm, and the bulk density is 0.75-0.95g / ml.

[0037] Homemade blank ball core prescription:

[0038] Sucrose (or lactose) 1-4Kg

[0039] Starch (or microcrystalline cellulose) 1-4Kg

[0040] 30-66% sucrose for sucrose syrup 3-5Kg

[0041] (or 1-4% hypromellose, 3-10% povidone or 3-10% polyethylene glycol) 0.1-0.5Kg

[0042] Preparation:

[0043] Grind sucrose (or lactose) through a 150 μm sieve, starch (or microcrystalline cellulose) through a 150 μm sieve, and prepare a mixed powder according to the prescription ratio. The sucrose syrup is heated and dissolved with sucrose plus the prescribed amou...

Embodiment 2

[0044] Embodiment 2: Preparation and coating of aspirin-containing pellets

[0045] The aspirin-containing pellets of the present invention can be prepared according to the following prescription using a telecentric coating machine or a modified sugar coating pan.

[0046] Prescription containing aspirin pellets:

[0047] Blank ball core 13-18Kg

[0048] Aspirin 6-10Kg

[0049] Starch (or microcrystalline cellulose) 1-4Kg

[0050] Sucrose (or lactose) 1-4Kg

[0051] 30-66% sucrose syrup 5-7Kg

[0052] (or 1-3% hypromellose, 3-10% povidone or 3-10% polyethylene glycol) 0.1-0.5Kg

[0053]Grind aspirin to a size of 150 μm, starch (microcrystalline cellulose) to a size of 150 μm, and sucrose (lactose) to a size of 150 μm, and make a mixed powder according to the prescription ratio. Heat and dissolve sucrose syrup with sucrose plus prescribed amount of purified water (or prepare hydroxypropylmethylcellulose, povidone, polyethylene glycol according to the concentration) and pa...

Embodiment 3

[0061] Embodiment 3: Preparation and coating of blank pellets

[0062] The blank pellets in the present invention can be prepared by using a telecentric coating machine or a modified sugar pan according to the following prescription.

[0063] Blank ball core 10-15Kg

[0064] Starch (or microcrystalline cellulose) 4-8Kg

[0065] Sucrose (or lactose) 4-8Kg

[0066] 30-66% sucrose for sucrose syrup 4-6Kg

[0067] (or 1-3% hypromellose, 3-10% povidone or 3-10% polyethylene glycol) 0.25-1.25Kg

[0068] The starch (microcrystalline cellulose) is crushed through 150 μm, the sucrose (lactose) is crushed through 150 μm, and mixed powder is made according to the prescription ratio. Heat and dissolve sucrose syrup with sucrose plus prescribed amount of purified water (or prepare hydroxypropylmethylcellulose, povidone, polyethylene glycol according to the concentration) and pass through a 150 μm sieve. Put the blank ball cores into the telecentric coating machine or the modified suga...

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Abstract

The present invention relates to a slowly-controllable released capsule preparation of aspirin and its preparation method. It mainly includes aspirin, sucrose, starch, ethyl alcohol, Tween-80, acrylic resin and talcum powder. Every 1000 capsule pills includes 100-350g of micropill containing medicine, in which the aspirin is 50g, 75g or 150g and blank micropill 0-200g. Its preparation method includes the following steps: covering blank pill core with aspirin to obtain micropill containing aspirin, screening to obtain medicine-containing micropill with required grain size, then covering it with controllable release film and capsulizing so as to obtain the invented product. Said product can reduce side effect and can raise therapeutic effect.

Description

technical field [0001] The invention relates to a sustained and controlled release capsule preparation of aspirin, in particular to a sustained and controlled release capsule preparation of aspirin and a preparation method thereof. Background technique [0002] Aspirin is a drug that has been used for nearly a hundred years. Its main pharmacological effects are antipyretic and anti-inflammatory in large doses, and it has a clear anticoagulant effect at 50-150 g, so it is used as a commonly used drug to prevent various types of thrombosis. But the side effects of aspirin, mainly gastrointestinal irritation, are also significant. It is especially noticeable with high doses or long-term use. There have been many medical reports about gastric ulcer and gastric bleeding caused by heavy use of aspirin. Aspirin enteric-coated tablets have been produced and sold to reduce gastric irritation, but the tablets are greatly affected by the gastric pyloric sphincter. It has been reporte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K31/60A61P7/02A61P29/00
Inventor 宋德成
Owner TIANJIN PACIFIC PHARMA
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