Slow and control release aspirin capsule formulation and method for making same

A technology of aspirin and capsules, which is applied in the field of aspirin sustained and controlled release capsule preparations and its preparation, can solve the problems of large impact, aggravated side effects, unstable blood drug concentration, etc., and achieve the effect of improving curative effect and reducing side effects
CN1522702AInactive Publication Date: 2004-08-25TIANJIN PACIFIC PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN PACIFIC PHARMA
Publication Date
2004-08-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a slowly-controllable released capsule preparation of aspirin and its preparation method. It mainly includes aspirin, sucrose, starch, ethyl alcohol, Tween-80, acrylic resin and talcum powder. Every 1000 capsule pills includes 100-350g of micropill containing medicine, in which the aspirin is 50g, 75g or 150g and blank micropill 0-200g. Its preparation method includes the following steps: covering blank pill core with aspirin to obtain micropill containing aspirin, screening to obtain medicine-containing micropill with required grain size, then covering it with controllable release film and capsulizing so as to obtain the invented product. Said product can reduce side effect and can raise therapeutic effect.
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Description

technical field

[0001] The invention relates to a sustained and controlled release capsule preparation of aspirin, in particular to a sustained and controlled release capsule preparation of aspirin and a preparation method thereof. Background technique

[0002] Aspirin is a drug that has been used for nearly a hundred years. Its main pharmacological effects are antipyretic and anti-inflammatory in large doses, and it has a clear anticoagulant effect at 50-150 g, so it is used as a commonly used drug to prevent various types of thrombosis. But the side effects of aspirin, mainly gastrointestinal irritation, are also significant. It is especially noticeable with high doses or long-term use. There have been many medical reports about gastric ulcer and gastric bleeding caused by heavy use of aspirin. Aspirin enteric-coated tablets have been produced and sold to reduce gastric irritation, but the tablets are greatly affected by the gastric pyloric sphincter. It has been reporte...

Claims

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