Method for preparing hydroxyapatite biodegradable aliphatic polyester composite material

A technology of hydroxyapatite and aliphatic polyester is applied in the field of preparation of hydroxyapatite biodegradable aliphatic polyester composite material, which can solve the problem of limiting the application range of composite materials, high toxicity of isocyanate and less covalent bond connection and other problems, to achieve the effect of high use value, uniform and stable dispersion, and good biocompatibility

Active Publication Date: 2004-11-10
CHANGCHUN SINOBIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method is far from meeting the requirements of practical applications. The toxicity of isocyanate is very high. Its addition limits the application range of composite materials and is not

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0025] Example 1:

[0026] Preparation of modified hydroxyapatite nanoparticles with lactic acid grafted on the surface. In three reaction flasks, 15g of hydroxyapatite (HA) nanoparticles (about 20-50nm in diameter) were dispersed in 80ml of tetrahydrofuran solvent, and 7.5ml, 15ml, 30ml were slowly added dropwise at room temperature and stirring. After the lactic acid is completely added, the reaction is stirred at 60°C for 3 hours, and then 200ml of toluene is added and the reaction is continued for 10 hours under the conditions of azeotropic dehydration. The product was washed 5 times with tetrahydrofuran and ethanol to remove unsupported lactic acid, and dried in vacuum at 40° C. for 48 hours to obtain modified hydroxyapatite nanoparticles with lactic acid on the surface. Infrared spectroscopy can verify the chemical connection between lactic acid and nanoparticles. The amount of lactic acid on the nanoparticles obtained by the thermogravimetric method is shown in Table 1.

[...

Example Embodiment

[0028] Example 2:

[0029] In Example 1, dioxane was used to replace the tetrahydrofuran solvent, and the test procedure and method were the same as in Example 1. The results of the content of grafted lactic acid on the surface of hydroxyapatite are shown in Table 2.

[0030]

Example Embodiment

[0031] Example 3:

[0032] In Example 1, xylene was used to replace the toluene dehydrating agent and dispersant, and the test procedure and method were the same as in Example 1. The results of the content of lactic acid grafted on the surface of hydroxyapatite are shown in Table 3.

[0033]

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Abstract

The invention provides a process for preparing a novel nanometer/ micrometer inorganic- biological degradable polyester composite material comprising, subjecting hydroxyapatite nanometer/micrometer particles and lactic acid to dewatering polycondensation reaction in organic solvent under the condition of heating and stirring, further reacting under toluene azeotropic dewatering condition, the dewatering polycondensation reaction can also be conducted to hydroxyapatite and lactic acid without the presence of solvent, grafting the hydroxyl of the particle surface of the hydroxyapatite to obtain the chemical constitution of lactic acid ester or low polylactic acid ester - hydroxyapatite, under the condition of waterless and oxygen free, using stannous octoate as initiating agent to trigger epsi-caprolactone, lactide, glycolide or cyclic ester monomer, and ring-opening polymerizing to obtain the homopolymer of epsi-caprolactone, lactide or glycolide biodegradable polyester and the nanometer/micrometer composite material of their dyadic and ternary copolymer.

Description

technical field [0001] The invention relates to a preparation method of a hydroxyapatite biodegradable aliphatic polyester composite material. Background technique [0002] Aliphatic polyesters, such as polylactide (PLA), polyε-caprolactone (PCL), and polyglycolide (PGA), are currently a class of fully biodegradable materials that are widely used. Aliphatic polyester has low immunity and good biodegradability, biocompatibility and mechanical strength, so it is widely used in biomedical and medical fields, such as: fracture fixation materials, surgical sutures, tissue engineering scaffold materials, drugs Sustained-release carrier materials, etc. [0003] Hydroxyapatite is a good degradable bone substitute material, and almost no adverse reactions occur in the human body. There have been a large number of literature reports that osteoblasts are more likely to grow on bone-like hydroxyapatite. The osseointegration ability of pure polylactic acid is low. A large number of stu...

Claims

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Application Information

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IPC IPC(8): C08K3/32C08L67/04
Inventor 陈学思邱学宇洪重奎景遐斌边新超杨立新徐效义
Owner CHANGCHUN SINOBIOMATERIALS
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