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Dried bacterial powder process containing gamma-linolenic acid

A technology of linolenic acid and dry bacteria powder, which is applied in the direction of medical preparations containing active ingredients, powder delivery, metabolic diseases, etc., can solve the problems of source limitation, lack of raw materials, irreplaceable and other problems, and achieve short production cycle and stable product quality , better results

Inactive Publication Date: 2005-05-11
王景恒 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, no drug can replace or exceed the effect of gamma-linolenic acid combined with traditional Chinese medicine on the human body
[0004] At present, the gamma-linolenic acid produced at home and abroad mainly comes from evening primrose, but due to the extreme shortage of raw materials and limited sources, it is far from meeting the growing domestic and foreign market demand

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Use γ-linolenic acid contained in plants or Cunninghamella cchinulata (scientific name Cunninghamella cchinulata) as the strain

[0043] The strains were screened under conditions in the incubator;

[0044] The slant culture of the bacteria was shaken at 25°C for 5 days;

[0045] Ferment for 3 days under the condition of 25 ℃ in the primary fermentation tank;

[0046] Fermentation at 25°C for 5 days in a secondary fermenter;

[0047] Ferment for 5 days under the condition of 25 ℃ in the three-stage fermenter;

[0048] Ferment for 7 days under the condition of 25 ℃ in the four-stage fermenter;

[0049] Then filter the bacteria and dehydrate the bacteria, and then shake and dry at 50°C;

[0050] Finally, 120-mesh crushing and sieving, aseptic vacuum packaging of the product and storage of the product.

[0051] The slant culture refers to the inoculation of the enlarged cultured strains in the liquid culture solution, and vibration culture at 25° C. for 5 days on a sh...

Embodiment 2

[0064] Using gamma-linolenic acid contained in plants and Cunninghamella cchinulata (scientific name Cunninghamella cchinulata) as strains:

[0065] The strains were screened under conditions in the incubator;

[0066] The slant culture of the bacteria was shaken at 28°C for 3 days;

[0067] Ferment for 3 days under the condition of 28 ℃ in the primary fermentation tank;

[0068] Ferment for 3 days under the condition of 28 ℃ in the secondary fermenter;

[0069] Fermentation for 3 days at 28°C in a three-stage fermenter;

[0070] Fermented for 6 days at 28°C in a four-stage fermenter;

[0071] Then filter the bacteria and dehydrate the bacteria, and then shake and dry at 60°C;

[0072] Finally, 160-mesh crushing and sieving, aseptic vacuum packaging of the product and storage of the product.

[0073] The slant culture refers to the inoculation of the enlarged cultured strains in the liquid culture solution, and vibration culture at 28° C. for 3 days on a shaker at 150 rpm...

Embodiment 3

[0086] Using gamma-linolenic acid contained in plants and Cunninghamella cchinulata (scientific name Cunninghamella cchinulata) as strains:

[0087] The strains were screened under conditions in the incubator;

[0088] The slant culture of the bacteria was shaken at 30°C for 2 days;

[0089] Ferment for 1 day under the condition of 30 ℃ in the primary fermentation tank;

[0090] Fermentation at 29°C for 2 days in a secondary fermenter;

[0091] Fermented for 2 days under the condition of 30°C in the three-stage fermenter;

[0092] Fermented for 5 days under the condition of 30 ℃ in the four-stage fermenter;

[0093] Then filter the bacteria and dehydrate the bacteria, and then shake and dry at 70°C;

[0094] Finally, 200-mesh crushing and sieving, aseptic vacuum packaging of the product and storage of the product.

[0095] The slant culture refers to the inoculation of the enlarged cultured strains in the liquid culture solution, and vibration culture at 30° C. for 2 days...

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Abstract

It was a new technique using gama-linolenic acid in the plant or Cunninghamellaechinulata as culture and producing dry fungus powder containing gama linolenic acid. There were the following characteristic: a) culture was inducted and filtered in the culture medium; b) slant culture of the strain was for 2-5 days at 25-30deg.C ; c) fermented for 1-3 days in the single stage fermentation can at 25-30deg.C; d) fermented for 2-5days in the second stage fermentation can at 25-29deg.C ; e) fermented for 2-5 days in the third stage fermentation can at 25-30deg.C ; f) fermented for 5-7 days in the fourth stage fermentation can at 25-30deg.C; g) the mycelium was filtrated and dehydrated to and then was shaked to dry at 50-70deg.C ; h) the product was crushed and sifted out from120-200 mu ,then it was enclosed in asepsis and enter warehouse.

Description

technical field [0001] The present invention relates to the production of biomedicines capable of treating and preventing various diseases such as AIDS, diabetes, hypertension, cardiovascular disease, endocrine disorders, etc. through induction and fermentation by using existing bacterial strains, especially a dry product containing γ-linolenic acid A new process for the production of bacterial powder. technical background [0002] γ-linolenic acid, chemical name: 6, 9, 12, octadecatrienoic acid, is all-cis, non-conjugated three-dimensional structure, molecular formula is C18H30O2. It is a colorless or light yellow oily liquid, which is unstable in the air due to its high degree of unsaturation, especially under high temperature conditions, it is prone to oxidation reaction, and it is prone to double bond position and configuration isomerism under alkaline conditions reaction to form conjugated polyenoic acid. [0003] As an essential fatty acid for the human body, γ-linol...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K38/44A61P3/10A61P9/10A61P9/12A61P31/18C12P1/02C12P7/64C12P21/00
Inventor 王景恒向芙戊
Owner 王景恒
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