Method for preparing night rest medicine and its solid preparation

A solid preparation, Ye Ning technology, applied in the field of preparation of Ye Ning medicine, can solve problems such as corruption, prolong production cycle, increase production cost, etc., achieve the effects of easy industrial production, ensure product quality, and ensure stability

Inactive Publication Date: 2005-05-18
丁青龙
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In this way, the alcohol-soluble sedative and hypnotic parts of Ganoderma lucidum are effectively extracted, and it also avoids starch gelatinization that may occur when the starch-rich floating wheat is fried together with other herbs, wrapping the effective parts of the medicinal materials, and causing them to not be fully fried. , affecting the overall curative effect of the prescription
Although the above-mentioned preparation method is scientific to a certain extent, there are still deficiencies: firstly, the alcohol-soluble active part of Ganoderma lucidum is extracted by using the traditional dipping extraction method, the dipping time is longer, prolonging the production cycle, and the concentration and amount of ethanol used are not accurate enough. If the ethanol concentration is too high or the dosage is too high, although the extraction rate can be guaranteed, it will increase the burden on the recovery process and increase the production cost; if the ethanol concentration is too low or the dosage is too small, the extraction rate cannot be guaranteed, which will affect the final product. curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0016] Example 1 Preparation of Yening Medicine

[0017] The following operations are carried out in the GMP purification workshop.

[0018] ①Weigh 21kg of Albizia julibrissin, 10kg of Ganoderma lucidum, 21kg of Shouwu vine, 15kg of jujube, 21kg of Ligustrum lucidum, 6kg of licorice, and 60kg of floating wheat for use;

[0019] ②Preparation of Ganoderma lucidum alcohol extract dry extract powder

[0020] Take 10 kg of Ganoderma lucidum crushed to 10 mesh, put it into an extraction tank, add 20 times the volume of Ganoderma lucidum with 60% ethanol, and extract at 80°C under reflux for 2 hours. After filtration, the filtrate is recovered from ethanol, concentrated under reduced pressure, and spray-dried to obtain an alcohol extract of Ganoderma lucidum. 0.6 kg of dry extract powder for use; the filtered ganoderma lucidum residue is stored for further processing;

[0021] ③Preparation of water-soluble extract of floating wheat

[0022] Add 60 kg of floating wheat to the extraction t...

Example Embodiment

[0034] Example 2 Preparation of solid preparation of Yening drug

[0035] 1. Yening hard capsules

[0036] In the GMP purification workshop, the Yening medicine prepared according to the method of Example 1 was crushed, passed through a No. 4 sieve, and then packed into capsule shells by a fully automatic capsule filling machine to produce 0.1 to 1 g Yening hard capsules of different specifications.

[0037] 2. Yening soft capsule

[0038] In the GMP purification workshop, 100 kg of the Yening drug prepared according to the method in Example 1 was crushed and passed through a 200-mesh sieve. 45 kg of it was mixed with 20 kg of polyethylene glycol, 7 kg of ethanol, 2 kg of water, 20 kg of polysorbate and 6 kg of glycerin. Evenly, the Yening soft capsules of different specifications of 0.4~1g are made by the compression method.

[0039] 3. Yening tablets

[0040] In the GMP purification workshop, the Yening drug prepared according to the method in Example 1 was crushed and passed th...

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PUM

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Abstract

The night rest medicine is developed on the classical recipe of night rest syrup. Its preparation process includes water extraction of light wheat, reflux extraction of glossy ganoderma with alcohol to obtain alcohol soluble extract of glossy ganoderma and concentration and drying to obtain dry glossy ganoderma extractum powder; water decoction of glossy ganoderma dregs, silktree albizia bark, fleeceflower stem, etc. and filtering to obtain filtrate; merging the light wheat extracting liquid and the filtrate, concentration and spray drying to obtain mixture dry extractum powder; and further mixing with the dry glossy ganoderma extractum powder to obtain the night rest medicine. The night rest medicine may be prepared into various preparation forms.

Description

technical field [0001] The invention relates to a preparation method of Yening medicine and its solid preparation. Background technique [0002] Yening Syrup is a classic Chinese patent medicine recorded in the 2000 edition of "Chinese Pharmacopoeia". , its curative effect is exact and reliable. The drug composition of Yening Syrup is: 105g of Albizia Julibrissin, 50g of Ganoderma lucidum, 105g of Shouwu vine, 75g of jujube, 105g of Ligustrum lucidum, 30g of licorice and 300g of floating wheat, and its dosage form is syrup. The preparation method of Yening syrup recorded in the "Chinese Pharmacopoeia" is: after the floating wheat is boiled with water, soak twice at 80-90°C for 2 hours each time, and combine the warm soaking liquid; Soak in ethanol for one week, collect the soaking liquid by filtration, and recover the ethanol for later use; decoct the dregs of the medicine with the bark of Albizia Julibrissin, Shouwu vine, jujube, licorice, and Ligustrum lucidum twice, for...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/16A61K9/20A61K9/48A61P25/20
Inventor 丁青龙李莹
Owner 丁青龙
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