Method for preparing night rest medicine and its solid preparation

Abstract

The night rest medicine is developed on the classical recipe of night rest syrup. Its preparation process includes water extraction of light wheat, reflux extraction of glossy ganoderma with alcohol to obtain alcohol soluble extract of glossy ganoderma and concentration and drying to obtain dry glossy ganoderma extractum powder; water decoction of glossy ganoderma dregs, silktree albizia bark, fleeceflower stem, etc. and filtering to obtain filtrate; merging the light wheat extracting liquid and the filtrate, concentration and spray drying to obtain mixture dry extractum powder; and further mixing with the dry glossy ganoderma extractum powder to obtain the night rest medicine. The night rest medicine may be prepared into various preparation forms.

Description

technical field [0001] The invention relates to a preparation method of Yening medicine and its solid preparation. Background technique [0002] Yening Syrup is a classic Chinese patent medicine recorded in the 2000 edition of "Chinese Pharmacopoeia". , its curative effect is exact and reliable. The drug composition of Yening Syrup is: 105g of Albizia Julibrissin, 50g of Ganoderma lucidum, 105g of Shouwu vine, 75g of jujube, 105g of Ligustrum lucidum, 30g of licorice and 300g of floating wheat, and its dosage form is syrup. The preparation method of Yening syrup recorded in the "Chinese Pharmacopoeia" is: after the floating wheat is boiled with water, soak twice at 80-90°C for 2 hours each time, and combine the warm soaking liquid; Soak in ethanol for one week, collect the soaking liquid by filtration, and recover the ethanol for later use; decoct the dregs of the medicine with the bark of Albizia Julibrissin, Shouwu vine, jujube, licorice, and Ligustrum lucidum twice, for...

AI Technical Summary

Problems solved by technology

In this way, the alcohol-soluble sedative and hypnotic parts of Ganoderma lucidum are effectively extracted, and it also avoids starch gelatinization that may occur when the starch-rich floating wheat is fried together with other herbs, wrapping the effective parts of the medicinal materials, and causing them to not be fully fried. , affecting the overall curative effect of the prescription

Although the above-mentioned preparation method is scientific to a certain extent, there are still deficiencies: firstly, the alcohol-soluble active part of Ganoderma lucidum is extracted by using the traditional dipping extraction method, the dipping time is longer, prolonging the production cycle, and the concentration and amount of ethanol used are not accurate enough. If the ethanol concentration is too high or the dosage is too high, although the extraction rate can be guaranteed, it will increase the burden on the recovery process and increase the production cost; if the ethanol concentration is too low or the dosage is too small, the extraction rate cannot be guaranteed, which will affect the final product. curative effect

But there is following shortcoming in above-mentioned method: 1. making nano particle involves many new production equipments and instruments, can make equipment investment increase; Decoction or separate decoction), it is likely to change the active ingredients of the extracts obtained after decocting different Chinese herbal medicines. Therefore, it is impossible to ensure that its curative effect is the same as that of the original Yening syrup; It must be the same. The extract is used to make nanoparticles, and then various preparations are made according to the prescription amount. Obviously, the same prescription as the original nighting syrup cannot be guaranteed.

[0003] In addition, Yening syrup is a syrup, and there are inherent problems in the preparation and storage: large dosage, incomplete absorption, easy to be contaminated by microorganisms during preparation and storage, and then mildew and spoilage occur, and it is easy to occur during storage. The precipitation of active ingredients affects the curative effect, and it cannot cover the bad smell of the drug well, and it is inconvenient to carry, etc.