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Application of microcapsule composition infusing to abdomen cavity for preventing carcinomatosis

A composition and cancer spreading technology, applied in the field of pharmaceuticals, can solve the problems that patients are difficult to accept, the expected therapeutic effect is not achieved, and it is difficult to control the drug concentration and drug effective action time, so as to prolong the action time and increase the bioavailability

Inactive Publication Date: 2005-06-01
SHENYANG EYE DROP RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The conventional method of intraperitoneal infusion of medicinal solution is to infuse limited drugs into one or several potential lesions in the abdominal cavity, all of which are liquid preparations (infusion of solid preparations is unacceptable to patients), and its disadvantage is that it is difficult to control the drug use. Concentration and effective action time of the drug, the bioavailability of the infused drug is low, and the toxic and side effects are large, which is generally difficult for patients to accept or does not achieve the expected therapeutic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0026] Example 1. Intraperitoneal infusion of cisplatin controlled-release microcapsules

[0027] Preparation: main ingredient: cisplatin; microcapsule carrier: gelatin, polylactic acid, polyvinyl alcohol, polyacrylic acid resins with quaternary ammonium groups and any one of polyacrylic resins; either method.

[0028] Solvent: sodium chloride physiological saline or glucose plasma isotonic solution, mixed in an amount of about 1:80-100ml per 1g of the drug component before use.

[0029] Peritoneal perfusion: After surgical resection of cancer tissue, perfuse the liver, bladder, uterus, lung and other tissues and organs in the abdominal cavity.

example 2

[0030] Example 2. Ondansetron

[0031] Preparation: main ingredient: ondansetron; microcapsule carrier: gelatin, polylactic acid, polyvinyl alcohol, polyacrylic acid resins with quaternary ammonium groups, and any one of polyacrylic resins; preparation method: adopt the aforementioned three preparation methods any of the methods.

[0032] Solvent: Sodium chloride physiological saline, phosphate buffer saline, glucose, mannitol or organic acid plasma isotonic solution, mixed in an amount of about 1:100-200ml per 1g of the drug component before use.

[0033] Peritoneal perfusion: Perfusion of various tissues and organs in the abdominal cavity is used to prevent and treat nausea and vomiting caused by chemotherapy drugs and radiotherapy.

example 3

[0034] Example 3. Lomustine

[0035] Preparation: main ingredient: lomustine; microcapsule carrier: any one of polyvinylpyrrolidone, gelatin, polylactic acid, chitosan, polyacrylic acid resins with quaternary ammonium groups and polyacrylic resins, and the preparation method: adopt the aforementioned Any of the 3 preparation methods.

[0036] Solvent: Sodium chloride physiological saline, carbonate buffer, glucose, mannitol, sorbic acid or organic acid plasma isotonic solution, mixed in an amount of about 1:100-150ml per 1g of drug ingredients before use,

[0037] Peritoneal perfusion: After surgical resection of cancer tissue, perfusion of lymph, lung and other tissues and organs in the abdominal cavity.

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PUM

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Abstract

The present invention relates to one kind of release controlling microcapsule preparation for preventing abdominal cavity carcinomatosis and its abdominal cavity infusing application technology. The release controlling microcapsule preparation is infused into abdominal cavity after cancer tissue incising operation and the medicine is released timely to prevent carcinomatosis and inhibit the growth of cancer cells. Technologically, the present invention includes three key aspects: preparing release controlling microcapsule, selecting proper solvent and abdominal cavity infusion technology. By means of the technology of combining release controlling microcapsule and abdominal cavity infusion, the present invention has high medicine bioavailability.

Description

technical field [0001] The invention belongs to the technical field of medicines. The invention relates to a controlled-release microcapsule preparation for preventing the spread of abdominal cancer and its application technology for intraperitoneal infusion. After the cancer tissue is removed, the preparation is infused into the abdominal cavity so that it is evenly distributed in various tissues and organs. The drug microcapsule The drug can be released quantitatively in the abdominal cavity at regular intervals, and the controlled release time is 7-14 days, which can effectively prevent the spread of cancer cells and inhibit the growth of cancer cells that have metastasized to other parts of the abdominal cavity. Background technique [0002] For cancerous lesions of intra-abdominal tissues and organs, surgical resection of the lesion is often used to remove various adverse physiological effects caused by cancerous lesions, so that patients can escape the pain and death t...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K9/52A61K45/00A61P35/00
Inventor 刘继东杨宇春唐世军宋长海
Owner SHENYANG EYE DROP RES
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