Chinese medicine preparation for treating rheumatism and preparation and use

A traditional Chinese medicine preparation, rheumatism technology, applied in the directions of non-central analgesics, antipyretics, anti-inflammatory agents, etc., can solve the problems of non-specific immunosuppression of the body, no effective treatment method, incomplete pathogenesis, etc. Less toxic and side effects, avoiding toxic effects, and significant curative effect

Inactive Publication Date: 2005-10-19
湖北中医学院
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  • Claims
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Problems solved by technology

Because its pathogenesis is not completely clear, there is no specific treatment at present (Lu Junjian, Chinese and Western Medicine Diagnosis and Treatment of Connective Tissue Diseases, People's Health Publishing

Method used

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  • Chinese medicine preparation for treating rheumatism and preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0017] Example 1

[0018] API W 3 Preparation

[0019] See attached figure 1

[0020] Take the coarse powder of Diwu, add 8-12 times of water and reflux for 3 to 4 times, 1 to 3 hours each time, combine the extracts, concentrate the extracts under reduced pressure to dryness, add 50% to 80% ethanol, and filter out the precipitate. Obtain the alcohol extract, concentrate to dryness under reduced pressure, add water to dissolve, filter, the filtrate is adsorbed on D101 macroporous resin, and eluted with water, 40%~80% ethanol, 80%~95% ethanol; 40%~80% collected Ethanol eluate, recover the ethanol and evaporate to dryness in a water bath to obtain the total glycosides of Diwu; apply the obtained total glycosides on silica gel dry column chromatography and elute with a mixture of chloroform: methanol: water = 20: 10:1 by volume , Roughly divided into 5 sections, detected by high performance liquid chromatography (TLC), collected the second section part rich in Diwu saponins W3, and th...

Example Embodiment

[0021] Example 2

[0022] Long-term toxicity test in rats:

[0023] To investigate the long-term toxicity of Diwu extract 864, 288, and 96 mg / kg by intragastric administration for 6 months. Observe the general conditions of the animals, weight changes, hematology, blood biochemistry, general anatomy of the whole body organs, organ coefficients and histopathological changes. Results None of the animals died. There were no statistical differences in the general conditions of the animal test of each dose group at the end of the 3-month test period and the recovery period, body weight changes, hematology, blood biochemistry, general organ anatomy, and organ coefficients compared with the negative control group. At the end of the experiment, the histopathological examination of each dose group showed that the proportion of hyperplastic lobules in thyroid follicular lobules was different. Among them, hyperplastic lobules accounted for more than 50% of the thyroid follicular lobules in t...

Example Embodiment

[0024] Example 3.

[0025] Beagle dog long-term toxicity test:

[0026] To investigate the long-term toxicity of Diwu extract at the doses of 128mg / kg, 256mg / kg and 512mg / kg for 9 months. Observe the general condition of the animal, weight change, stool and urine routine, electrocardiogram, hematology, blood biochemistry, general organ anatomy, organ coefficient and histopathological changes. As a result, none of the animals died. There was no significant difference in the indicators of the high, medium, and low-dose groups in the 3 months, 6 months, 9 months and recovery period compared with the blank control group. Long-term toxicity test results show that Diwu extract is safe to be fed to Beagle dogs at 128 mg / kg, 256 mg / kg and 512 mg / kg for 9 consecutive months.

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Abstract

The Chinese medicine preparation, Fengshi'an, for treating rheumatism has the effective component 3-O-alpha-L-pyranorhamnose (1->2)-beta-D-xylopyranose-oleanolic acid-28-O-alpha-L-pyranorhamnose(1->4) beta-D-pyranoglucose (1->6) beta-D-glucopyranoside, named flaccid anemone saponin W3, and with molecular expression of C59H96O25. Flaccid anemone saponin W3 is prepared with coarse flaccid anemone rhizome powder, and through reflux extraction, concentration, adsorption and elution in macroposrous resin, adsorption and elution in dry silicon gel column and liquid separation. Flaccid anemone saponin W3 is further prepared into Chinese medicine preparation with flaccid anemone saponin W3 content over 90 wt%, and the Chinese medicine preparation is used in treating rheumatic diseases with high curative effect and less toxic side effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for rheumatic diseases and its preparation and application. Background technique [0002] Rheumatic diseases are common autoimmune diseases that can affect multiple organs and tissues. Clinical morbidity is high. Because its pathogenesis is not completely clear, there is no specific treatment at present (Lu Junjian, Chinese and Western Medicine Diagnosis and Treatment of Connective Tissue Diseases, People's Medical Publishing House, 1992: 348). Clinically, comprehensive treatment such as corticosteroid hormones and cytotoxic drugs is often used, but this often causes adverse consequences such as non-specific immunosuppression of the body. [0003] The dried rhizome of Anemone flaccida Fr. Schmidt, a plant of the genus Anemone (Anemone flaccida Fr. Schmidt) in the Ranunculaceae family. It is recorded in "Guizhou Folk Medicine" and "Zhejiang Tianmu Mountain Drug Chronicle" that it is ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P19/02A61P29/00
Inventor 邴飞虹
Owner 湖北中医学院
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