Chinese medicine preparation for treating rheumatism and preparation and use

Abstract

The Chinese medicine preparation, Fengshi'an, for treating rheumatism has the effective component 3-O-alpha-L-pyranorhamnose (1->2)-beta-D-xylopyranose-oleanolic acid-28-O-alpha-L-pyranorhamnose(1->4) beta-D-pyranoglucose (1->6) beta-D-glucopyranoside, named flaccid anemone saponin W3, and with molecular expression of C59H96O25. Flaccid anemone saponin W3 is prepared with coarse flaccid anemone rhizome powder, and through reflux extraction, concentration, adsorption and elution in macroposrous resin, adsorption and elution in dry silicon gel column and liquid separation. Flaccid anemone saponin W3 is further prepared into Chinese medicine preparation with flaccid anemone saponin W3 content over 90 wt%, and the Chinese medicine preparation is used in treating rheumatic diseases with high curative effect and less toxic side effect.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine preparation for rheumatic diseases and its preparation and application. Background technique

[0002] Rheumatic diseases are common autoimmune diseases that can affect multiple organs and tissues. Clinical morbidity is high. Because its pathogenesis is not completely clear, there is no specific treatment at present (Lu Junjian, Chinese and Western Medicine Diagnosis and Treatment of Connective Tissue Diseases, People's Medical Publishing House, 1992: 348). Clinically, comprehensive treatment such as corticosteroid hormones and cytotoxic drugs is often used, but this often causes adverse consequences such as non-specific immunosuppression of the body.

[0003] The dried rhizome of Anemone flaccida Fr. Schmidt, a plant of the genus Anemone (Anemone flaccida Fr. Schmidt) in the Ranunculaceae family. It is recorded in "Guizhou Folk Medicine" and "Zhejiang Tianmu Mountain Drug Chronicle" that it is ...

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