Astragalus glycoside fatty emulsion and its preparation technology

A technology of astragaloside IV fat and astragaloside IV, which is applied in the direction of emulsion transportation, medical preparations containing active ingredients, anti-toxins, etc., can solve the problems of poor water solubility and easy precipitation, so as to ensure safety and effectiveness, and improve The effect of stability and advanced preparation technology

Inactive Publication Date: 2005-10-26
JIANGSU QINGJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the main drug is wrapped in oil, this preparation form has good stability, low toxicity, low irritation, less adverse reactions, and has a certain slow-release property, which not only solves the problem of poor water solubility and easy precipitation, but also ensures clinical drug use. Safety and Effectiveness

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Under the protection of nitrogen, weigh 30 g of soybean oil, heat to 40°C, add 1 g of egg yolk lecithin and 0.001 g of astragaloside IV under high-speed stirring, and stir evenly as the oil phase. Add 1 g of glycerol for injection to 600 ml of water for injection, mix well and filter with a 0.45 μm filter membrane as the water phase. Add the oil phase to the water phase under high-speed stirring to make colostrum. Add water for injection to 1000ml, adjust the pH to 3.0, homogenize with a high-pressure homogenizer to obtain a white milky liquid, filter, fill, seal, and sterilize.

Embodiment 2

[0028] Under the protection of nitrogen, weigh 50 g of soybean oil, heat to 60°C, add 10 g of egg yolk lecithin and 1 g of astragaloside IV under high-speed stirring, and stir evenly as the oil phase. Add 20 g of glycerol for injection to 600 ml of water for injection, mix well and filter with a 0.45 μm filter membrane as the water phase. Add the oil phase to the water phase under high-speed stirring to make colostrum. Add water for injection to 1000ml, adjust the pH to 5.0, homogenize with a high-pressure homogenizer to obtain a white milky liquid, filter, fill, seal, and sterilize.

Embodiment 3

[0030] Under the protection of nitrogen, weigh 100 g of sesame oil, heat it to 50°C, add 12.5 g egg yolk lecithin and 0.5 g astragaloside IV under high-speed stirring, and stir evenly as the oil phase. Add 22.5 g of glycerol for injection to 500 ml of water for injection, mix well and filter with a 0.45 μm filter membrane as the water phase. Add the oil phase to the water phase under high-speed stirring to make colostrum. Add water for injection to 1000ml, adjust the pH to 8.0, homogenize with a high-pressure homogenizer to obtain a white milky liquid, filter, fill, seal, and sterilize.

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PUM

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Abstract

A lipid emulsion of astragaloside A is proportional prepared from astragaloside A, oil, surfactant, isotonic regulator, cosolvent and water for injection. Its preparing process is also disclosed.

Description

Technical field: [0001] The invention relates to an astragaloside IV fat emulsion and a preparation process thereof. Background technique: [0002] Astragaloside IV is one of the monomers of astragalus. In addition to its anti-inflammatory, antihypertensive, and improving myocardial ischemia effects, recent studies have shown that it has the following pharmacological effects: it can inhibit the increase in the amount of malondialdehyde in brain tissue after cerebral ischemia , And improve the activity of glutathione peroxidase; it has obvious anti-liver injury (hepatitis, liver fibrosis, liver tumor), treatment of rheumatoid arthritis and anti-aging effects; it has the effect of renal ischemia-reperfusion injury in rats Protective effect; has a protective effect on rats with early diabetic nephropathy. Astragaloside IV is extremely active, especially in diabetic nephropathy and anti-tumor. [0003] Astragaloside IV is difficult to dissolve in water, and the higher the purity, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048
Inventor 张来芳晏彩霞蔡紫阳张喜全
Owner JIANGSU QINGJIANG PHARMA
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