Unlock instant, AI-driven research and patent intelligence for your innovation.

Cinnamon twig and poria soft capsule and its preparation method

A technology of cinnamon twigs and soft capsules, which can be used in capsule delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve the problems of hard capsules, such as bad smell, slow drug dissolution rate, and slow absorption by the human body, to prevent Dispersion of bitter taste and bad smell, easy control of loading difference, not easy to oxidize and volatilize

Inactive Publication Date: 2005-10-26
温光辉 +1
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The main defects in the prior art are: firstly, the drug dissolution rate in the hard capsule is slow, resulting in slow absorption by the human body and slow drug effect; secondly, the hard capsule drug is easy to emit bitter taste and bad smell, which is not easy for patients to accept; It is difficult to control the difference in the drug loading of concentrated hard capsules made of traditional Chinese medicine extracts; finally, the hard capsules have poor sealing performance, the fatty acids in the drug are easily oxidized, and volatile components such as cinnamic acid and cinnamic aldehyde are easy to escape, resulting in The active ingredients are reduced and cannot be stored for a long time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] [embodiment 1] ethanol extraction

[0030] 1.1 The influence of the fragmentation degree of medicinal materials on the extraction

[0031] Take cinnamon twigs, peach kernels, white peony root, peony cortex and poria cocos according to the prescription and break them into particles of different particle sizes, extract them according to the extraction process of cinnamon twigs and poria cocos capsules, and investigate the ointment rate of alcohol extraction, water extraction ointment rate, and alcohol extraction liquid The content of paeonol, the content of paeoniflorin in the alcohol extract, and the content of paeoniflorin in the water extract.

[0032] try

test

No

break

broken

Spend

alcohol extract

Creaming rate

water extract

Creaming rate

Alcohol Extraction Zhongdan

Skin phenol content

(g)

Peony in Alcohol Extract

Glycoside content (g)

Paeoniae officinalis in w...

Embodiment 2

[0038] [embodiment 2] the concentration of alcohol extract

[0039] Take the alcohol extracts and concentrate them at 60°C, 80°C, 100°C and normal pressure to the liquid extracts with a relative density of 1.25 (50°C), respectively measure the paeonol content in each liquid extract, and then draw the Yield of paeonol in concentrated liquid extract. The experimental results are shown in Table 4.

[0040] sample number

[0041] As can be seen from the above table, when the concentration temperature is controlled below 80°C, the yield of paeonol is about 70%, which is the preferred solution of the present invention.

Embodiment 3

[0042] [embodiment 3] water extraction

[0043] Taking the number of extractions, the amount of water added, and the extraction time as the investigation factors, using the ointment yield and the content of paeoniflorin in the extract as the investigation index, the experiment was carried out according to the L9(3)4 orthogonal experiment table, and the water extraction was determined according to the analysis of the experimental results. craft. For the factor levels of its orthogonal experiment, see

[0044] Level

[0045] The test results show that: with the ointment yield as the index, the factor C has the greatest influence, and the factor A has the least influence, and the best process is A2B3C3; taking the paeoniflorin content as the index, the factor C has the greatest influence, and the factor A has the least influence.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention discloses a kind of soft cassia twig and tuckahoe capsule, which is prepared by mixing evenly extract powder by 10-40 percents weight and supplementary material by 60-90 percents weight and being colloid milled to prepare the soft capsule content particle, then dropping or pressing the soft capsule content particle to produce with capsule material. Wherein, the extract powder is prepared by alcohol-extracting cassia twig, tuckahoe, peach kernel, white peony root and tree peony bark, and concentrating the extracting solution, water-extracting and concentrating the extracting solution, then combining two concentrating solutions, then drying and crushing the same after adding Tuckahoe. And the supplementary material includes at least vegetable oil as diluent. The present invention has fast acting, good sealing, homogeneous effective components and stable curative effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine and a preparation process thereof, in particular to a traditional Chinese medicine soft capsule and a preparation process thereof. Background technique [0002] Guizhi Fuling Capsule is a compound preparation composed of five traditional Chinese medicines, namely Guizhi, Poria, Peach Kernel, Paeoniae Alba and Cortex Moutan. It has the effects of promoting blood circulation and removing blood stasis, and alleviating blockages. It is used for women with persistent lumps in the lower abdomen caused by blood stasis, heavy menstrual flow or continuous bleeding, dark purple blood, multiple blood clots, dull pain in the lower abdomen or abdominal pain refusal to press, dark tongue with ecchymosis, astringent or thready pulse. [0003] The main defects in the prior art are: firstly, the drug dissolution rate in the hard capsule is slow, resulting in slow absorption by the human body and slow drug effect;...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
Inventor 温光辉史林
Owner 温光辉