Orally disintegrated Ubenimex tablet and its prepn process

A technology of orally disintegrating tablets and ubenimex, which is applied in the field of medicine and its preparation, can solve the problems of unfavorable absorption, inconvenient and inconvenient medication, and achieve the effects of reducing irritation, rapid onset of effect, and improving compressibility

Inactive Publication Date: 2005-12-14
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most cancer patients have vomiting symptoms after radiotherapy or chemotherapy, so it is inconvenient to take medicine, especially for the elderly, children, patients with swallowing difficulties or patients in special circumstances.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] In the prescription of this embodiment, the active ingredient ubenimex accounts for 5% by mass ratio. Disintegrants are low-substituted hydroxypropyl cellulose and microcrystalline cellulose 19%; soluble diluent sorbitol 60%; binder povidone 5%; lubricant silicon dioxide 4%; , the flavoring agent aspartame and mint essence accounted for 7%.

Embodiment 2

[0018] In the prescription of this embodiment, the active ingredient ubenimex accounts for 10% by mass ratio. The disintegrant is low-substituted hydroxypropyl cellulose and crospovidone 21%; soluble diluent maltitol 54%; binder povidone 5%; lubricant silicon dioxide 5%; There are flavoring agents aspartame and sweet orange essence accounting for 5%.

Embodiment 3

[0020] In the prescription of this embodiment, the active ingredient ubenimex accounts for 10% by mass ratio. Disintegrants are croscarmellose sodium and microcrystalline cellulose accounted for 16%; soluble diluent mannitol accounted for 68%; binder hydroxypropyl cellulose accounted for 2%; lubricant micronized silica gel and silicon dioxide 4%.

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PUM

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Abstract

The orally disintegrated Ubenimex tablet consists of Ubenimex as active component and supplementary material including disintegrating agent, soluble diluent, adhesive and lubricant. The disintegrating agent is mixture of 2 or 3 of low substituted hydroxypropyl cellulose, cross-linked carboxymethyl cellulose, cross-linked sodium carboxymethyl starch, cross-linked polyvidon and microcrystalline cellulose. The preparation process is the combination of wet pelletizing and direct tabletting. The orally disintegrated Ubenimex tablet has fast disintegration, administration convenience, fast absorption, high bioavailability, and less irritation to gastrointestinal tract.

Description

technical field [0001] The invention belongs to the field of medicines and preparation methods thereof, in particular to an orally disintegrating tablet and a preparation method thereof. Background technique [0002] Ubenimex exhibits anti-tumor effect by activating anti-tumor immune function. It has the effect of inhibiting cell proliferation, used alone or in combination with other chemotherapy drugs can inhibit tumor growth and metastasis, and prolong the survival period of patients. As an immunomodulator, Ubenimex is mainly used in patients with acute and chronic leukemia. [0003] Currently on the market Ubenimex is an oral dosage form. For example, Baishixin Capsules whose approval number is Guoyao Zhunzi (1998) X-348. The common name is ubenimex, and the chemical name is N-[(2S,3R)-4-phenyl-2-hydroxybutyryl]-L-leucine. Baishixin capsules are used in combination with other chemotherapy drugs for the treatment of acute myeloid leukemia, chronic myelogenous leukemia,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/198
Inventor 滕利荣孟庆繁田晓乐高海鹰王贞佐
Owner JILIN UNIV
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