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Peripheral nerve regeneration conduit and process for preparing the same

A technology for peripheral nerves and catheters, applied in biochemical equipment and methods, catheters, microorganisms, etc., can solve problems such as inability to provide damaged nerves, compression of regenerative nerves, prolong absorption time, etc., achieve good plasticity, and less toxic and side effects , the effect of improving quality and speed

Inactive Publication Date: 2006-02-08
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chitin tubes and chitosan tubes are absorbable nerve conduits that have been studied more at present, but the current problem of this material is that it is relatively brittle, and when the tube wall is thin, it will be broken and depressed; if the tube wall is made too thick , it will prolong the absorption time and produce local compression on the regenerative nerve
However, because these materials still have various problems in terms of mechanical properties, degradation and absorption speed, etc., especially the inability to provide the required nutrients for damaged nerves, the nerve induction repair surgery performed with biodegradable polymer materials has so far been have not yet been applied clinically

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Dry the absorbable polymer polyglycolide-lactide (PGLA) (the ratio of GA to LA is 90:10) in an oven at 100°C for 24 hours, The melt with a temperature of 210°C is produced inside, sprayed out from the spinneret by a metering pump, and solidified in the filament chamber. The medium in the filament chamber is air, and the temperature is room temperature; the prepared primary fiber is wound on the bobbin Above, the winding speed is 200 m / min; the as-spun fiber on the bobbin is subjected to two-stage stretching, the first-stage stretching temperature is 70°C, the second-stage stretching temperature is 80°C, and the total draw ratio is 5.0 times; followed by heat setting in an oven at a temperature of 100°C; the finished fibers are braided, the parameters are: when the inner diameter of the catheter is 2.80 mm, the yarn count is 330tex, the number of spindles of the braiding machine is 24, and the braiding angle is 60°; Carry out setting then, parameter is: setting temperatu...

Embodiment 2

[0046] Dry the absorbable polymer polyglycolide-lactide (PGLA) (the ratio of GA to LA is 85:15) in an oven at 100°C for 24 hours, The melt with a temperature of 210°C is produced inside, sprayed out from the spinneret by a metering pump, and solidified in the filament chamber. The medium in the filament chamber is air, and the temperature is room temperature; the prepared primary fiber is wound on the bobbin Above, the winding speed is 100 m / min; the as-spun fiber on the bobbin is subjected to two-stage stretching, the first-stage stretching temperature is 75°C, the second-stage stretching temperature is 85°C, and the total draw ratio is 6.0 times; followed by heat setting in an oven at a temperature of 100°C; the finished fibers are braided, the parameters are: when the inner diameter of the catheter is 0.80 mm, the yarn count is 55tex, the number of spindles of the braiding machine is 12, and the braiding angle is 600; then Carry out setting, parameter is: setting temperatur...

Embodiment 3

[0048] Dry the absorbable polymer polyglycolide-lactide (PGLA) (the ratio of GA to LA is 90:10) in an oven at 100°C for 24 hours, The melt is produced at a temperature of 215°C, sprayed out from the spinneret by a metering pump, and solidified in the filament chamber. The medium in the filament chamber is air, and the temperature is room temperature; the prepared primary fiber is wound on the bobbin Above, the winding speed is 200 m / min; the as-spun fiber on the bobbin is subjected to two-stage stretching, the first-stage stretching temperature is 80°C, the second-stage stretching temperature is 90°C, and the total draw ratio is 3.5 times; followed by heat setting in an oven at a temperature of 100°C; the finished fibers are braided, the parameters are: when the inner diameter of the catheter is 5.00 mm, the yarn count is 495tex, the number of spindles of the braiding machine is 32, and the braiding angle is 65°; Carry out setting then, parameter is: setting temperature 60 ℃ s...

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Abstract

The invention discloses a peripheral nerve regeneration tube and its manufacturing method, comprising: using the biodegradable material via the weave to attain the tube, and the surface of tube has chitinase and its derivant, a coating of nerve growth factor whose thickness is 0.01-0.5 mm, and the molecular weight of chitinase and its derivant is 50-0.5 million. The degradation cycle of said inventive peripheral nerve regeneration tube is synchronous to the peripheral nerve regeneration, and the invention can induce the nerve to grow quick with better elasticity and anchorage force, therefore, it can effectively improve the quality and speed of nerve regeneration. In addition, the invention can bridge connect the damaged nerve in 80 mm, to reach the advanced world level.

Description

1. Technical field [0001] The invention relates to a medical material and a preparation method thereof, more particularly to a peripheral nerve regeneration catheter made of PGLA material and a preparation method thereof. 2. Background technology [0002] Biomedical materials are the product of the intersection of life science and material science. They are an important material basis for the development of modern clinical medicine. Their products have extremely high added value. At present, they have become a research hotspot in countries all over the world, and their development momentum is booming. [0003] Since the beginning of the 20th century, the repair, regeneration and functional recovery of peripheral nerves have been one of the difficult and hot topics in the field of neuroscience research. Until this year, with the development of microsurgical techniques, the repair of damaged nerves , the therapeutic effect has been significantly improved, but it is still diffi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/00A61M39/08A61L27/00C12N5/08
Inventor 郯志清陈南梁沈新元张佩华杨庆王文祖沈尊理
Owner DONGHUA UNIV
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