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Changsanye-factor oral liquor and clinical use

A technology of intestinal trefoil factor and oral preparations, applied in pill delivery, medical preparations containing active ingredients, digestive system, etc., can solve problems such as non-specificity, promotion of gluconeogenesis, interference with glucose metabolism, etc.

Inactive Publication Date: 2006-03-08
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But most of them are non-specific. In addition to promoting intestinal mucosal proliferation and repair, they also affect other cell functions. For example, growth hormone can interfere with glucose metabolism and promote gluconeogenesis, which limits its application in diabetic patients and severe trauma patients. Another example is fibroblast growth factor, insulin-like growth factor, etc., which have the side effects of promoting the expression of bacterial drug resistance genes and promoting the growth of tumor cells.
In conclusion, the current biopharmaceutical preparations prepared from the above-mentioned prodrugs have many defects in the treatment of gastrointestinal diseases

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048]After mixing 5.3kg of lactose, 6g of linguinin and 50g of colorant, add 0.48kg of gum arabic to make a uniform soft material, and pass through a 16-mesh sieve to granulate. The wet granules are dried in an oven at 45°C, and the dry granules are passed through a 14-mesh sieve for granulation. Another 50ml of 95% ethanol was mixed with 10g of peppermint oil, and sprayed evenly on the dry granules. Add 60g of magnesium stearate evenly, put it in an open container for 1 hour, then add 0.1g of intestinal trefoil factor, 30g of sucralfate and 10g of glycine, 5g of lysine, 15g of vitamin C, 1g of Na 3 PO 4 Add the mixture after mixing, and press 10,000 tablets, each containing ITF10μg.

Embodiment 2

[0050] Preparation process is with embodiment 1, and batching is as follows:

[0051] Intestinal trefoil factor (any one of the above ITF) 0.1g

[0052] Sucralfate 10g

[0053] Chitin 15g

[0054] Vitamin C 15g

[0055] Na 3 PO 4 1g

[0056] Lactose 5.4kg

[0057] Stevioside 10g

[0058] Citric acid 40g

[0059] Colorant 40g

[0060] Gum Arabic 0.35kg

[0061] peppermint oil 20g

[0062] Polyethylene glycol 12g

[0063] Press 10,000 tablets, and each tablet contains 10 μg of ITF.

Embodiment 3

[0065] Preparation process is with embodiment 1, and batching is as follows:

[0066] Intestinal trefoil factor (any one of the above ITF) 0.1g

[0067] Hydroxyprolyl Cellulose 60g

[0068] Glycine 20g

[0069] Lysine 10g

[0070] Chitin 8g

[0071] Vitamin C 20g

[0072] Na 3 PO 4 0.5g

[0073] Sucrose 5.1g

[0074] Stevioside 10g

[0075] Citric acid 40g

[0076] Colorant 50g

[0077] Gelatin 0.6kg

[0078] peppermint oil 10g

[0079] Press 10,000 tablets, and each tablet contains 10 μg of ITF.

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PUM

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Abstract

The enteric trilobate factor oral preparation is characterized by that it contains enteric trilobate factor as pharmacodynamic active component, also contains enteric trilobate factor activating agent and enteric trilobate factor protecting agent, so that it can be used for curing the diseases of ulcer of digestive tract, radiation enteritis, chronic gastritis and enteritis.

Description

1. Technical field [0001] The invention belongs to pharmaceutical preparations containing protein materials, in particular to a biomedical preparation containing specific growth factor-intestinal trefoil factor (abbreviated as ITF, hereinafter the same). 2. Background technology [0002] The gastrointestinal tract is the corridor through which food and water lead to the body. It is often subjected to mechanical and chemical impacts (especially strong acids and alkalis), and is often attacked by other harmful or toxic substances. Compared with other organs, it is more affected. More chances of loss. Modern medical research shows that the gastrointestinal tract is very sensitive to ischemic and hypoxic damage, and the gastrointestinal tract is one of the most vulnerable organs in the body under various pathological conditions. Therefore, how to reduce gastrointestinal damage and promote damage repair is particularly important. Although the currently clinically used gastroint...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/10A61K9/14A61K9/16A61K9/20A61K9/48A61K9/00A61P1/04
Inventor 彭曦孙勇汪仕良黄跃生
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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