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Micro fluid device and process for producing the same

A technology of microfluidic devices and manufacturing methods, which is applied in the direction of chemical instruments and methods, instruments, scientific instruments, etc., can solve problems such as unknown, and achieve the effects of increased sensitivity, increased sample volume, and high yield

Inactive Publication Date: 2006-04-12
KAWAMURA INST OF CHEM RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, also regarding this method, there is as yet no known method of providing this resin in a uniform thickness on the inner surface of the tiny channels of a microfluidic device.

Method used

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  • Micro fluid device and process for producing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0145] Example 1 is an example of producing a porous resin layer having a three-dimensional network structure according to the "reaction-induced phase separation method".

[0146] [Preparation of film deposition solution (J)]

[0147] 72 parts of trifunctional urethane acrylate oligomer (Unidic V-4263, Dainippon Ink and Chemicals) with an average molecular weight of 2000, 18 parts of dicyclopentanyl diacrylate (R-684, Nippon Kayaku ), 10 parts glyceryl methacrylate (Wako Pure Chemical Industries), 150 parts methyl caprate (Wako Pure Chemical Industries), 10 parts a well-volatile solvent in the form of acetone, and 3 parts 1-hydroxycyclohexyl phenyl ketone (Irgacure 184, Ciba-Geigy) UV polymerization initiators were uniformly mixed to prepare a film deposition solution (J1).

[0148] [Preparation of Composition (X)]

[0149] 50 parts of trifunctional urethane acrylate oligomer (Unidic V-4263, Dainippon Ink and Chemicals) with an average molecular weight of 2000, 40 parts of h...

Embodiment 2

[0170] Example 2 is an example of producing a porous resin layer having a three-dimensional network structure according to the "surface swelling method".

[0171] [Preparation of Composition (X)]

[0172] Composition (X2) was prepared in the same manner as the preparation method of Example 1 composition (X1), except that 40 parts of 1,6-hexanediol ethoxylated diacrylate (Photomer 4361, Cognis Japan) instead of 40 parts of hexanediol diacrylate (New Frontier HDDA, Daiichi Pharmaceutical), and mixed with 10 parts of nonylphenoxy polyethylene glycol (n=17) acrylate (N-177E, Daiichi Pharmaceutical) instead of 10 parts Glyceryl methacrylate (Wako Pure Chemical Industries). The viscosity of this composition was 220 mPa·s.

[0173] [Step 1: Formation of a porous resin layer having a three-dimensional network structure]

[0174] (with the formation of a three-dimensional network structure)

[0175] After immersing a polystyrene plate (Dainippon Ink and Chemicals) with a thickness of...

Embodiment 3

[0190] Example 3 is an example of manufacturing a porous resin layer having a three-dimensional network structure according to the "wet method".

[0191] [Preparation of film deposition solution (K)]

[0192] 5 parts of linear polymer in the form of aromatic polyamide (Conex, Teijin), 90 parts of solvent (U) in the form of N,N-dimethylacetamide (Wako Pure Chemical Industries), and 5 parts of additives in the form of ethylene glycol Mix uniformly to obtain a film deposition solution (K).

[0193] [Preparation of Composition (X)]

[0194] 50 parts of tris(tetraethylene glycol) bismaleimide (Lumicure MIA200, Dainippon Ink and Chemicals), 40 parts of 1,6-hexanediol ethoxylated diacrylate (Photomer 4361, CognisJapan), 10 parts of N A composition (X3 ). The viscosity of the composition (X3) was 100 mPa·s.

[0195] [Step 1: Formation of a porous resin layer having a three-dimensional network structure]

[0196] (Formation of three-dimensional network structure)

[0197] Using ...

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Abstract

A process for producing a micro fluid device in which a porous resin layer capable of fixing a most appropriately large amount of proteins, such as enzymes and antigens, catalysts, etc. on the inside surface of minute channels of the micro fluid device without clogging of the channels is provided with a uniform thickness on the surface of the channels. Providing of a porous resin layer with a uniform thickness on the surface of the channels can be easily accomplished through a process comprising forming in advance on a support a porous resin layer having a multiplicity of pores on its surface, applying an actinic energy radiation hardening composition onto the porous resin layer so as to form depressed portions having the porous resin layer at bottoms thereof, and thereafter securing a covering member to the depressed portions so as to provide channels.

Description

technical field [0001] The present invention relates to a microfluidic device having a porous resin layer adopting a three-dimensional network structure on the inner surface of a channel, and a method for manufacturing the device. Background technique [0002] In recent years, in various fields, including medical diagnosis and biochemical tests, attempts have been made to analyze components of fluids containing trace amounts of DNA, biological substances, and the like using microfluidic devices. [0003] Microfluidic devices are also referred to as microfluidic devices, microfabricated devices, lab-on-a-chips, and micro-total analysis systems (μ-TAS), and are performed in tiny capillaries contained inside the device. Reaction and analysis, which can speed up reaction and analysis, reduce the amount of reagents required and reduce waste products. [0004] In the case of using such a microfluidic device to react with a sample in a fluid state by immobilizing enzymes, catalyst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/60B01J20/281G01N37/00G01N27/447B81C99/00G01N30/52G01N30/56G03F7/20
CPCG01N2030/562G01N30/6095G01N2030/525G01N30/6052Y10T137/2224
Inventor 高田哲生穴泽孝典寺前敦司
Owner KAWAMURA INST OF CHEM RES
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