Composite fiber membrane with chiral molecular imprint and its prepn and application

A chiral molecule and fiber composite technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve problems such as poor sharing, difficult continuous operation, and high cost

Inactive Publication Date: 2006-05-17
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Generally speaking, a specific chiral resolution method is only effective for the resolution of certain chiral compounds, but not for other chiral compounds. The sharing is poor, it is difficult to operate continuously, and the cost is relatively high. There is often a lot of blindness in the separation process (such as the choice of chiral split ligand reagents)

Method used

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  • Composite fiber membrane with chiral molecular imprint and its prepn and application
  • Composite fiber membrane with chiral molecular imprint and its prepn and application
  • Composite fiber membrane with chiral molecular imprint and its prepn and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] First, weigh raw materials according to mass percentage, azobisisobutyronitrile: 6%, acetonitrile: 94%, and prepare an initiator solution. The process is: add AIBN to acetonitrile and shake gently to dissolve AIBN. Then apply the solution evenly on the outer surface of the pre-prepared PSF hollow fiber, and let it dry.

[0051] Then weigh raw materials by mass percentage, chiral compound dibenzoyl-L-tartaric acid: 2%; Acetonitrile: 60%; Methyl methacrylate: 5%; Ethylene glycol dimethacrylate: 32% to prepare Coating solution, the process is: first add L-DBTA to acetonitrile, shake it gently to dissolve it, let it stand for 2 hours at a temperature of 25°C, then add methyl methacrylate and ethylene glycol dimethacrylate, shake it Evenly, it is the coating solution. Then apply the coating solution evenly on the outer surface of the PSF hollow fiber membrane coated with the initiator, and after standing for 3 hours, place the PSF hollow fiber membrane in a vacuum drying oven...

Embodiment 2

[0056] According to the preparation conditions and process described in Example 1, the material is a hollow fiber ultrafiltration membrane of polyethersulfone (PES) as a support, and the others are the same as in Example 1. Repeat the process of Example 1 to obtain chiral The molecularly imprinted composite membrane is assembled into a membrane module, and the separation factor of the racemic L, D-DBTA solution can reach 2.0.

Embodiment 3

[0058] According to the preparation conditions and process described in Example 1, levofloxacin is used as the template molecule, and the others are the same as in Example 1, and the process of Example 1 is repeated to prepare the levofloxacin chiral molecularly imprinted composite film, and assemble Membrane-forming components, the separation factor of the racemic ofloxacin solution can reach 1.7.

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Abstract

The present invention discloses composite fiber membrane with chiral molecular imprint and its preparation process and application. The composite fiber membrane with chiral molecular imprint has excellent identifying selectivity. For example, the composite fiber membrane with L-DBTA as template molecule has high identifying selectivity on L-DBTA only, low identifying selectivity on other compounds and separation factor on racemic L, D-DBTA solution up to 2.7. Altering the temperature molecules can obtain different composite fiber membrane for separating several kinds of racemic compounds.

Description

technical field [0001] The invention relates to a method for preparing a molecularly imprinted composite membrane, in particular to a method for preparing a chiral molecularly imprinted composite membrane. Background technique [0002] Molecular Imprinting Technique (Molecular Imprinting Technique) is a technology that uses molecularly imprinted polymers to carry out specific molecular recognition on the "memory" function of the three-dimensional structure and shape of imprinted molecules. Therefore, it is predetermined and recognizable. Since 1993, Mosbach et al Since the report on molecularly imprinted polymers that can separate theophylline was published in "Nature", it has developed rapidly and has become an interdisciplinary field of chemistry, biology, polymer materials, medicine and other disciplines. Separation, immunoassay, antibody simulation, imitation biosensor, catalyst and synthetic enzyme have shown good application prospects. [0003] Molecular imprinting te...

Claims

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Application Information

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IPC IPC(8): B01D67/00B01D69/08B01D71/00
Inventor 许振良杨座国魏永明杨虎
Owner EAST CHINA UNIV OF SCI & TECH
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