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Preparation process of total salvianolic acid

A technology of total phenolic acid and resin of salvia miltiorrhiza, which is applied in the field of medicine, can solve the problems of loss of curative effect, difficulty, and high production cost, and achieve the effects of avoiding the loss of active ingredients of phenolic acids, less loss of active ingredients, and lower production costs

Active Publication Date: 2011-05-11
CHENGDU DIAO JIUHONG PHARMA FAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are some problems in the preparation of salvia miltiorrhiza by the above methods, which affect the yield of industrialization and finished products.
First of all, most of the above methods are extracted by boiling water or heating for a long time (50-60°C), and salvianolic acid is a polyphenol structure, which is easily oxidized and degraded by heat, and loses its curative effect, thus seriously affecting the quality of the product. quality and curative effect; secondly, most extraction methods adopt the step of high-concentration ethanol precipitation, which greatly reduces the safety of industrial production, the consumption of ethanol is large, and the production cost is high; thirdly, when the above-mentioned method is extracted, a large amount of concentrated water is needed, It is not convenient for industrialized large-scale production, and the operation is relatively complicated; the fourth, the yield of salvianolic acid extracted by the above-mentioned method is low, generally 2 to 4%, and the low yield also increases the cost of industrialized production and brings difficulties

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Extracting Salvia phenolic acids from the traditional Chinese medicine Salvia miltiorrhiza

[0024] Salvia miltiorrhiza 5kg, softened by steam. Cut into pieces, add 25L of deionized water, cold soak for 6h, percolate for 24h, flow rate 2L / h. Collect 45L of percolation liquid, centrifuge, put on macroporous adsorption resin column HPD100, elute with 7.5L of water, add 20L of 70% ethanol to elute, collect ethanol eluate, dry under reduced pressure, temperature is controlled at 60°C. Obtain salvianolic acid dry powder 320g, finished product yield 6.4%. After testing, the salvianolic acid B content was 71.2%, and the total phenolic acid content was 90.4%.

[0025] Detection method of salvianolic acid B and total salvianolic acid:

[0026] (1) Salvianolic acid B: determined by HPLC method, the detection wavelength is 285nm, and the standard salvianolic acid B is provided by China Institute for the Control of Pharmaceutical and Biological Products, with a purity ...

Embodiment 2

[0031] Example 2 Extracting total phenolic acids of Salvia miltiorrhiza from Chinese medicine Salvia miltiorrhiza

[0032] Salvia miltiorrhiza 5kg, softened by steam. Cut into pieces, add 25L of deionized water, cold soak for 24h, percolate for 18h, flow rate 2L / h. Collect 45L of the percolation solution, centrifuge, put it on a macroporous adsorption resin column HPD100, elute with 7.5L of water, then add 20L of 95% ethanol, collect the ethanol eluate, dry it under reduced pressure, and control the temperature at 60°C. Obtain salvianolic acid dry powder 300g, finished product yield 6%. Measured by the method of Example 1, the salvianolic acid B content was 62.7%, and the total phenolic acid content was 86.4%.

Embodiment 3

[0033] Example 3 Extracting the total phenolic acid of Salvia miltiorrhiza from Chinese medicine Salvia miltiorrhiza

[0034] Salvia miltiorrhiza 5kg, softened by steam. Cut into pieces, add 25L of deionized water, cold soak for 12h, percolate for 12h, flow rate 2L / h. Collect 45L of percolation solution, centrifuge, put on macroporous adsorption resin column HPD100, elute with 7.5L of water, add 20L of 80% ethanol to elute, collect ethanol eluate, dry under reduced pressure, the temperature is controlled at 60°C. Obtain salvianolic acid dry powder 275g, finished product yield 5.5%. Measured by the method of Example 1, the salvianolic acid B content is 61.5%, and the total phenolic acid content is 82.5%.

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PUM

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Abstract

The present invention discloses preparation process and use of total salvianolic acid. The preparation process includes soaking red sage in cold water, percolating extraction, macroporous resin adsorption of the percolate, elution, decompression concentrating the eluted liquid, and drying to obtain total salvianolic acid. The preparation process is simple, high in yield, low in power consumption,safe, pollution-less and easy to industrialize. The obtained total salvianolic acid is used as medicine for preventing and treating cardiac and cerebral vascular diseases, etc.

Description

technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine extract, in particular to a method for extracting salvia miltiorrhiza from the traditional Chinese medicine Salvia miltiorrhiza, belonging to the technical field of medicine. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia salviz miltiorrhiza Bge., a plant of the Labiatae family. It has the effects of promoting blood circulation and removing blood stasis, cooling blood and eliminating carbuncle, eliminating troubles and calming the nerves. Modern pharmacological studies have confirmed that Danshen has the effects of dilating blood vessels, improving microcirculation, increasing myocardial oxygen supply and blood supply, and reducing myocardial oxygen consumption. Danshen mainly contains water-soluble and fat-soluble components. The fat-soluble component is a quinone compound represented by tanshinone, which has obvious anti-inflammat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/53A61P9/00A61K125/00A61K135/00
Inventor 张志峰付铁军刘忠荣李伯刚
Owner CHENGDU DIAO JIUHONG PHARMA FAB
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