Process of preparing squalene

A technology of squalene and squalene, which is applied in chemical instruments and methods, purification/separation of hydrocarbons, hydrocarbons, etc., can solve the problems of complex step reaction and small experimental scale, and achieve abundant wood resources and easy operation Convenience and high promotional value

Inactive Publication Date: 2006-08-02
SOUTH CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Up to now, the artificial synthesis of squalene has the disadvantages of too many steps and complex reactions, or the experimental scale is too small (only at the mmol level), which is quite different from the actual application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Material preparation: The wood of Eucalyptus urophylla is made into wood powder through a flaker and a crusher, 2kg;

[0028] (2) Extraction: Use petroleum ether (boiling point 70±10℃) to extract the crude squalene-containing extract from Eucalyptus urophylla powder with a microwave extractor. Extraction conditions: bath ratio V 溶剂 / V 木 3:1, temperature 55℃, reflux time 4h;

[0029] (3) Separate: Use 5% hydrochloric acid, 5% sodium hydroxide solution, cold water, boiling water, and absolute ethanol in V 溶剂 / V 粗提物 It is 10:1 at room temperature (wherein boiling water leaching temperature is 100℃) through continuous extractor to dissolve non-hydrocarbon compounds from the crude extract of step (2), thereby obtaining a pure squalene-containing hydrocarbon mixture ;

[0030] (4) Purification: The squalene-containing hydrocarbon mixture is subjected to molecular distillation with a molecular distillation apparatus under a vacuum of 1.330 Pa for 3 molecular distillations, whe...

Embodiment 2

[0032] (1) Material preparation: The wood of Eucalyptus urophylla is made into wood powder through a chipper and a crusher, 2kg;

[0033] (2) Extraction: Use an organic solvent mixture of petroleum ether (boiling point 75±10℃) and n-hexane in a volume ratio of 1:1 to extract the crude squalene-containing powder from Eucalyptus urophylla powder by ultrasonic extraction. Extract, extraction conditions: bath ratio V 溶剂 / V 木 50:1, temperature 65℃, reflux time 2h;

[0034] (3) Separation: Use 3% sulfuric acid, 5% sodium carbonate solution, cold water, and absolute ethanol in the V 溶剂 / V 粗提物 It is 50:1 at room temperature through continuous extractor to dissolve non-hydrocarbon compounds from the crude extract of step (2), and then use boiling water in V 溶剂 / V 粗提物 When the ratio is 50:1, dissolve non-hydrocarbon compounds from the crude extract of step (2), thereby obtaining a purer squalene-containing hydrocarbon mixture;

[0035] (4) Purification: The squalene-containing hydrocarbon m...

Embodiment 3

[0037] (1) Material preparation: The wood chips of Eucalyptus urophylla are made into wood chips through a chipper and a chipper, 2kg;

[0038] (2) Extraction: The crude extract containing squalene is extracted from Eucalyptus urophylla wood chips with a 2:1 organic solvent mixture of ethanol and benzene in a volume ratio by cold soaking method. Extraction conditions: bath ratio V 溶剂 / V 木 5:1, temperature 75℃, reflux time 4h;

[0039] (3) Separation: Use 8% phosphoric acid, 10% sodium bicarbonate solution, cold water, and absolute ethanol in V 溶剂 / V 粗提物 The ratio is 1:1, the non-hydrocarbon compounds are dissolved out from the crude extract of step (2) through the continuous extractor at room temperature, and then use boiling water in the V 溶剂 / V 粗提物 When it is 1:1, dissolve non-hydrocarbon compounds from the crude extract of step (2), thereby obtaining a purer squalene-containing hydrocarbon mixture;

[0040](4) Purification: The squalene-containing hydrocarbon mixture is subject...

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Abstract

The present invention provides process of extracting squalene from Weiju eucalyptus, and the process includes the steps of preparing material, extraction, separation and purification. The process has low cost, convenient operation and high yield, and can utilize the rich Weiju eucalyptus resource to meet the industrial need and extend the industrial chain of timber industry and papermaking industry.

Description

Technical field [0001] The invention relates to a method for preparing squalene, in particular to a method for extracting squalene from Eucalyptus urophylla wood. Background technique [0002] Squalene is a long-chain triterpene compound, aliased as squalene, squalene, hexadecene, squalene or cod liver oil terpene, and its systematic names are 2, 6, 10, 15, 19, 23-hexamethyl-2,6,10,14,18,22-docosahexaene, the molecular formula is C 30 H 50 , The relative molecular weight is 410.7, it is a colorless or slightly yellow clear oily liquid, which is mainly distilled from deep-sea shark liver oil. Squalene is an unsaturated hydrocarbon compound that is beneficial to human health. It has an oxygen-carrying function similar to red blood cells. It can improve the oxygen-carrying capacity of human hemoglobin, enhance cell viability, promote metabolism, enhance immunity, and promote bile Secretion, lower serum total cholesterol, adjust lipoprotein ratio, prevent arteriosclerosis, etc., fore...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C11/21C07C7/00
Inventor 彭万喜李凯夫
Owner SOUTH CHINA AGRI UNIV
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