Tetrandrine solid lipide nano particle and its preparing method

A technology of solid lipid nanometer and tetrandrine, which is applied to the solid lipid nanoparticle preparation of tetragonin and its preparation, and the field of active ingredients of traditional Chinese medicine fangji, which can solve the problem of large toxic and side effects, small safety range, and application range. Restrictions and other issues, to achieve the effects of formulation optimization, high encapsulation efficiency, and small particle size
CN1813737AInactive Publication Date: 2006-08-09XI AN JIAOTONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2006-08-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses a tetrandrine solid lipid nano particles preparation and its preparation method. Said invention uses the tetrandrine extracted from Chinese medicinal material stephaniae tetrandrae radix as medicinal effective component, uses the lipid material of stearic acid, etc. as carrier, uses soybean phospholipid as emulsifying agent and adopts ultrasonic method and high-pressure uniform emulsification method to make the tetrandrine be coated and carried in the solid lipid nano particles so as to obtain the invented product.
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Description

technical field

[0001] The invention belongs to the field of nanometer traditional Chinese medicine preparations, in particular to a solid lipid nanoparticle preparation of tetrandrine, an active ingredient of the traditional Chinese medicine tetrandrine, and a preparation method thereof. Background technique

[0002] Solid lipid nanoparticles (SLN) is a new colloid drug delivery system developed in the early 1990s that can replace emulsions, liposomes and polymeric nanoparticles. It contains solid lipid components that are available, biodegradable, and less toxic than polymeric nanoparticles. Compared with liposomes, since the drug is encapsulated in the framework of the solid liposome, there is no leakage of the drug during storage. SLN also has slow-release, controlled-release and targeting effects. After intravenous administration, it is quickly swallowed by the reticuloendothelial system and passively enters the liver and spleen to achieve liver targeting.

[0003] T...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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