Tetrandrine solid lipide nano particle and its preparing method

A technology of solid lipid nanometer and tetrandrine, which is applied to the solid lipid nanoparticle preparation of tetragonin and its preparation, and the field of active ingredients of traditional Chinese medicine fangji, which can solve the problem of large toxic and side effects, small safety range, and application range. Restrictions and other issues, to achieve the effects of formulation optimization, high encapsulation efficiency, and small particle size

Inactive Publication Date: 2006-08-09
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But tetrandrine is insoluble in water, and its common preparation bioavailability is not high, also has no tissue targeting effect, has influenced the therapeutic effect of this medicine; The scope of clinical use of the drug is subject to certain restrictions

Method used

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  • Tetrandrine solid lipide nano particle and its preparing method
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  • Tetrandrine solid lipide nano particle and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Weigh 70 mg of tetrandrine, 60 mg of stearic acid and 150 mg of soybean lecithin, and dissolve them in 10 ml of absolute ethanol in a 70°C water bath to form an organic phase solution.

[0030] (2) Measure 15ml of glycerin and disperse in 30ml of distilled water to form a water phase, and place it on a constant temperature magnetic stirrer at a temperature of 80°C and a stirring speed of 1000rpm.

[0031] (3) Inject the organic phase obtained in step (1) into the aqueous phase obtained in step (2), and stir for 1.5 hours to form a milky white suspension and form colostrum.

[0032] (4) ultrasonically treat the colostrum prepared in step (3) for 300 seconds, stir to room temperature, filter with a 0.45 μm microporous membrane to remove the titanium particle impurities released by the ultrasonic probe, and obtain tetrandrine solid lipid nanoparticle water Dispersion, sealed and stored at 4°C.

[0033] Detection: the average particle diameter of the tetrandrine solid ...

Embodiment 2

[0035] (1) Weigh 65 mg of tetrandrine, 45 mg of cholesterol and 120 mg of lecithin, and dissolve them in 9.5 ml of ethyl acetate in a water bath at 70°C to form an organic phase solution.

[0036] (2) Measure 15ml of mannitol and disperse in 30ml of distilled water to form an aqueous phase, and place it on a constant temperature magnetic stirrer at a temperature of 75°C and a stirring speed of 800rpm.

[0037] (3) Inject the organic phase prepared in step (1) into the aqueous phase prepared in step (2), and stir for 1 hour to form a milky white suspension and form colostrum.

[0038](4) ultrasonically treat the colostrum prepared in step (3) for 400 seconds, stir to room temperature, filter with a 0.45 μm microporous membrane to remove impurities such as titanium particles released by the ultrasonic probe, and obtain tetrandrine solid lipid nanoparticles Water dispersion, sealed and stored at 4°C.

[0039] Detection: The Tetrandrine solid lipid nanoparticles prepared by this ...

Embodiment 3

[0041] (1) Weigh 250 mg of tetrandrine, 150 mg of stearic acid and 450 mg of soybean lecithin, and dissolve them in 30 ml of absolute ethanol in a 75°C water bath to form an organic phase solution.

[0042] (2) Measure 45ml of glycerin and disperse in 95ml of distilled water to form a water phase, and place it on a constant temperature magnetic stirrer at a temperature of 80°C and a stirring speed of 1300rpm.

[0043] (3) Inject the organic phase prepared in step (1) into the aqueous phase prepared in step (2), and stir for 2 hours to form a milky white suspension and form colostrum.

[0044] (4) ultrasonically treat the colostrum prepared in step (3) for 600 seconds, stir to room temperature, filter with a 0.45 μm microporous membrane to remove impurities such as titanium particles released by the ultrasonic probe, and obtain tetrandrine solid lipid nanoparticles Water dispersion, sealed and stored at 4°C.

[0045] Detection: The Tetrandrine solid lipid nanoparticles prepare...

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Abstract

The present invention discloses a tetrandrine solid lipid nano particles preparation and its preparation method. Said invention uses the tetrandrine extracted from Chinese medicinal material stephaniae tetrandrae radix as medicinal effective component, uses the lipid material of stearic acid, etc. as carrier, uses soybean phospholipid as emulsifying agent and adopts ultrasonic method and high-pressure uniform emulsification method to make the tetrandrine be coated and carried in the solid lipid nano particles so as to obtain the invented product.

Description

technical field [0001] The invention belongs to the field of nanometer traditional Chinese medicine preparations, in particular to a solid lipid nanoparticle preparation of tetrandrine, an active ingredient of the traditional Chinese medicine tetrandrine, and a preparation method thereof. Background technique [0002] Solid lipid nanoparticles (SLN) is a new colloid drug delivery system developed in the early 1990s that can replace emulsions, liposomes and polymeric nanoparticles. It contains solid lipid components that are available, biodegradable, and less toxic than polymeric nanoparticles. Compared with liposomes, since the drug is encapsulated in the framework of the solid liposome, there is no leakage of the drug during storage. SLN also has slow-release, controlled-release and targeting effects. After intravenous administration, it is quickly swallowed by the reticuloendothelial system and passively enters the liver and spleen to achieve liver targeting. [0003] T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4748A61K9/127A61P1/16A61P31/14
Inventor 厉英超
Owner XI AN JIAOTONG UNIV
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