Compound medicinal formulation for treating acute-chronic vespiratory tract infection and its preparing method

A technology for pharmaceutical preparations and respiratory tract, applied in the field of medicine, can solve the problems of affecting the therapeutic effect, large dosage, difficult dosage control, etc., and achieve the effects of improving the therapeutic effect, taking a small dosage and facilitating clinical application.

Inactive Publication Date: 2006-08-09
西安新安医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Respiratory tract infection is often accompanied by phlegm, and a large amount of sputum affects the absorption of drugs, thereby affecting the therapeutic effect
At present, in the clinical treatment of respiratory tract infections, single-use antibiotics (such as azithromycin) or expectorants (such as ambroxol hydrochloride, erdosteine, etc.) are often used, and the dosage is relatively large; The method of compatibility of expectorant preparations is used to treat respiratory tract infection diseases, but often the dosage of compatibility application is not accurate enough
In a word, the drugs in the existing treatment methods have disadvantages such as poor curative effect, large dosage, and difficult dosage control.

Method used

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  • Compound medicinal formulation for treating acute-chronic vespiratory tract infection and its preparing method
  • Compound medicinal formulation for treating acute-chronic vespiratory tract infection and its preparing method
  • Compound medicinal formulation for treating acute-chronic vespiratory tract infection and its preparing method

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Embodiment 1: the preparation of azithromycin ambroxol sheet

[0030] Prescription: Azithromycin hydrochloride 250g (calculated as azithromycin)

[0031] Ambroxol Hydrochloride 60g

[0032] Starch 30g

[0033] Microcrystalline Cellulose 45g

[0034] Micronized silica gel 2g

[0035] Talc powder 4.5g

[0036] Magnesium Stearate 2.5g

[0037] Proper amount of hydroxypropyl methylcellulose (E-30) (4% solution)

[0038] Made into 1000 pieces

[0039] Preparation method: Prepare 4% hydroxypropyl methylcellulose (E-30) solution and set aside. Weigh 10 g of starch and dry at 105°C for 5 hours for later use. Take by weighing 20g of starch and azithromycin hydrochloride, ambroxol hydrochloride, microcrystalline cellulose of prescription quantity, mix, pulverize and cross 80 mesh sieves. Use 4% hydroxypropyl methylcellulose (E-30) solution to make the material into a soft material, granulate it with a 20-me...

Embodiment 2

[0039] Preparation method: Prepare 4% hydroxypropyl methylcellulose (E-30) solution and set aside. Weigh 10 g of starch and dry at 105°C for 5 hours for later use. Take by weighing 20g of starch and azithromycin hydrochloride, ambroxol hydrochloride, microcrystalline cellulose of prescription quantity, mix, pulverize and cross 80 mesh sieves. Use 4% hydroxypropyl methylcellulose (E-30) solution to make the material into a soft material, granulate it with a 20-mesh sieve, and dry it at 50-60°C until the water content in the granule is about 3%. Pass through a 20-mesh sieve for granulation, add dry starch (dried at 105°C for 5 hours), magnesium stearate, micronized silica gel, and talcum powder in the prescribed amount, and finally mix, measure the content of intermediates, and determine the tablet weight; tablet. Embodiment 2: the preparation of azithromycin fudosteine ​​sheet

[0040] prescription:

[0041] Azithromycin hydrochloride 125g (calculated as azithromycin)

...

Embodiment 3

[0051] Embodiment 3: the preparation of azithromycin ambroxol dry suspension

[0052] prescription:

[0053] Azithromycin hydrochloride 250g (calculated as azithromycin)

[0054] Ambroxol Hydrochloride 30g

[0055] Sucrose 720g

[0056] Made into 1000g

[0057] Preparation method: Weigh azithromycin hydrochloride, ambroxol hydrochloride and sucrose according to the above prescription, crush them through a 60-mesh sieve, mix them evenly, and pack them in packaging bags, 1g per bag.

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PUM

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Abstract

The present invention relates to a compound medicine preparation for curing acute and chronic respiratory tract infection. It is made up by using azithromycin and phlegm-removing active component according to the weight mixing ratio of 1:0.05-2.

Description

Technical field: [0001] The invention relates to a medicine, in particular to a compound chemical medicine preparation for treating acute and chronic respiratory infections. technical background: [0002] Respiratory tract infection is a common infectious disease. The pathogenic microorganisms are mainly bacteria, followed by viruses and mycoplasma. my country is a country with a high incidence of bacterial infectious diseases. Due to factors such as air pollution, the number of children infected is particularly high. Respiratory tract infection is often accompanied by phlegm, and a large amount of sputum affects the absorption of drugs, thereby affecting the therapeutic effect. At present, in the clinical treatment of respiratory tract infections, single-use antibiotics (such as azithromycin) or expectorants (such as ambroxol hydrochloride, erdosteine, etc.) are often used, and the dosage is relatively large; The method for the compatibility of expectorant preparations is...

Claims

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Application Information

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IPC IPC(8): A61K31/7052A61K31/145A61K31/137A61P11/00
Inventor 苏红军
Owner 西安新安医药科技有限公司
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