Cosmetic compositions containing fullerene clusters

A cosmetic composition and composition technology, applied in the direction of cosmetics, cosmetics, medical preparations containing active ingredients, etc., can solve the problem of reducing the number of double bonds, reducing the specific reactivity of fullerenes, and no one has successfully prepared fullerenes, etc. question

Inactive Publication Date: 2006-09-13
奈尔·伯兰古洛夫 +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the addition of functional groups to fullerene molecules endows fullerene derivatives with the necessary solubility, the preparation of these derivatives inevitably leads to a reduction in the number of double bonds and, concomitantly, a reduction in the ability of fullerene molecules to scavenge free radicals.
In addition, the functional groups create steric hindrance to the interaction of fullerene cage double bonds with free radicals in solution, thereby further reducing the specific reactivity of fullerenes
[0010] To date, no one has succeeded in preparing pharmacologically or biologically active fullerenes without the addition of functional groups to the fullerene cage

Method used

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  • Cosmetic compositions containing fullerene clusters
  • Cosmetic compositions containing fullerene clusters

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0200] Will C 60 Vacuum sublimation of the crystalline solvate of , followed by grinding in an agate mortar in an argon-dried box to crystallites averaging about 10 μm yielded a solvent-free fullerene C with a purity of 99.9% by weight 60 . 400 mg of this powder was added to a thin-walled polyethylene test tube, followed by deionized (DI) water to 3 ml, and the open end heat sealed. Pass the sample thus prepared through an electrohydraulic device ( figure 2 ) through the small hole in the upper cover, which is inserted into a cavity filled with deionized water, which is circulated through the cooler. Fix the sample with a special fixture so that the fullerene powder is located at the upper focus of the ellipsoid. A series of discharges at a pulse frequency of 2 Hz were performed at the lower focus of the ellipsoid for a total of 2 hours, with a 5 μF capacitor charged to 6,000 V between pulses with a high-voltage power supply. The device produced about 75J of energy per pu...

Embodiment 2

[0202] For 400 mg of fullerene C with a purity of 99.9% by weight 60 The suspension in 3 ml of clarified olive oil was subjected to the same EH treatment as in Example 1, except that the total treatment time was 4 hours. The process must be interrupted several times to adjust the gap between the electrodes, which increases due to spark erosion of the electrodes. The prepared product was diluted with ethanol at 1:10,000, and then a small drop of ethanol solution on a polished aluminum carrier was dried to obtain a sample. High-resolution SEM examination showed that there were fullerene clusters with an average diameter of about 20 nm in the sample. The prepared product is stored in the refrigerator and is easily dissolved in a large amount of olive oil or other natural oils that can be used cosmetically under gentle sonication.

Embodiment 3

[0204] 100 mg of finely ground 99.9% pure fullerene C by magnetic stirrer 60 The slurry in 200 ml of reagent grade ethanol was maintained, suspended, in a two-necked glass flask, which was further circulated with a peristaltic pump at a rate of 20 ml / min in a closed loop comprising PTFE thin tubes passing through figure 2 The upper focus of the middle ellipsoid cavity. The EH treatment conditions are the same as those in Example 1, except that the treatment time is 4 hours. After the product was filtered through a 0.22 μm PTFE filter, a reddish milky white solution was obtained with a fullerene concentration of about 0.25 mg / ml. SEM studies confirm that there are a large number of fullerene clusters with a diameter of 7-30nm and larger clusters with a diameter of 50-150nm, which account for about 1 / 3 of the mass of the entire sample. Aliquots of the product were stored in the refrigerator without signs of precipitation for at least 5 months. Additional prolonged sonication...

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Abstract

The present invention is directed to a cosmetic composition comprising effective amounts of fullerene clusters in association with cosmetically acceptable carrier to prevent or retard fee radical oxidation processes in the skin and to the methods of using said composition for reducing damage to healthy skin or mucous membranes by free radicals.

Description

field of invention [0001] The present invention relates to dispersed fullerene ultrafine particles and their use in cosmetics. Background of the invention [0002] Fullerenes are the third allotrope of carbon, which differ from other forms of carbon such as diamond or graphite. It consists only of carbon atoms arranged in a hollow closed cage. More specifically, fullerenes consist of closed polyhedra in which the carbon atoms are connected to form hexagons and pentagons. The stabilized fullerenes used in the present invention are produced in industrial or laboratory scale quantities. Examples include C 60 、C 70 、C 76 、C 78 、C 80 、C 82 、C 84 and higher molecular weight molecules. [0003] Fullerenes were first described by Kroto et al. (Nature, vol. 318, p. 163 (1985)), whose existence was postulated based on the mass spectrum of the products of laser-evaporated graphite. When Huffman and Kratschmer found the preparation and separation of macroscopic fullerenes (su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/81A61K8/84A61Q19/00A61Q17/04A61Q1/00A61K8/02A61K8/30A61K8/49A61K8/86A61K33/44
CPCA61K2800/522A61K8/02A61K8/8176A61Q19/00A61K8/19A61K33/44A61K8/4913A61Q17/04A61K8/86A61P31/00A61K8/81B82Y5/00
Inventor 奈尔·伯兰古洛夫亚历山大·P·莫拉夫斯基尤雅·V·库里科娃乔治·I·戴亚楚克拉乌夫·O·洛特菲
Owner 奈尔·伯兰古洛夫
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