Puerarin self-emulsifying microemulsified composition and its preparation method

A composition and technology of puerarin, applied in the field of puerarin self-emulsifying microemulsion composition and its preparation, can solve the problems of poor puerarin solubility, increased cost, low bioavailability of puerarin tablets, etc., and achieve improved bioavailability , the effect of improving solubility

Inactive Publication Date: 2006-09-27
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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Problems solved by technology

Currently, there are only two formulations of puerarin on the market: injection and tablet. Due to the poor solubility of puerarin in water, only 1.1×10 -2 mol / l, so it is necessary to add a large amount of high-viscosity propylene glycol to aid dissolution, which not only increases the cost, but also causes difficulty in filtration in production due to the high viscosity, and the oral bioavailability of puerarin tablets is low, so it is necessary A new oral formulation of puerarin, convenient for patients

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  • Puerarin self-emulsifying microemulsified composition and its preparation method
  • Puerarin self-emulsifying microemulsified composition and its preparation method

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Embodiment Construction

[0019] Puerarin self-emulsifying microemulsion composition, it is the solution that comprises puerarin, oil phase, surfactant, co-surfactant, it is characterized in that described solution is the microemulsion that particle diameter is less than 100nm, and this microemulsion is at least Containing a hydrophilic surfactant of polyoxyethylene with HLB (Chinese) value greater than 10, the amount of surfactant is 15-60% of the weight of the microemulsion without water, preferably 25-50%, so The surfactant is selected from condensation products of sorbitan fatty acid esters, polyoxyethylene castor oil and polyoxyethylene hydrogenated castor oil; at least one oil phase with 15 to 25 carbon atoms in the carbon chain, The content of the oil phase is 2 to 15% of the total weight of the microemulsion, and the selected oil phase is selected from refined vegetable oil, peanut oil, ethyl oleate, ethyl linoleate, isopropyl myristate, tricaprylic caprylate Glyceride or triglyceride myristate...

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Abstract

The self-emulsified puerarin micro emulsion composition contains puerarin, and micro emulsion system comprising polyoxyethylenefatty acid ester as the surfactant, medium carbon chain fatty acid ester as the oil phase and polyhydroxyl alcohol as co-surfactant. The preparation process includes dissolving puerarin in co-surfactan at 10-80 deg.c, cooling, mixing Tween-80 with surfactant, adding oil phase through stirring, and adding certain amount of water solution through stirring to form the micro smulsion. The self-emulsified puerarin micro emulsion composition has relatively high stability, and may be diluted with water into transparent low viscosity micro emulsion.

Description

Technical field: [0001] The invention relates to a drug self-emulsifying microemulsion composition and other manufacturing methods, in particular to a puerarin self-emulsifying microemulsion composition and a preparation method thereof. Background technique: [0002] Puerarin is a flavonoid glycoside extracted from the root of the leguminous plant Pueraria lobata. The use of kudzu root to treat general diseases has been recorded in ancient Chinese medical works "The Classic", "Treatise on Febrile Diseases" and "Dictionary of Medicine". Japan's "Niyangshijian" and "Waka Food Materia Medica" also record that Pueraria lobata has the effects of "sweet, non-toxic, heat removal, thirst quenching, laxative, hangover, and stomach nourishing". In 1959, the Japanese Shibata Chengji’s research on the chemical components of Pueraria lobata showed that isoflavones are the main active components of Pueraria lobata, among which puerarin, daidzein and daidzein are more abundant. In China,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/107A61P9/10A61P1/10A61P25/32
Inventor 贾晓斌陈彦潘国梁
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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