Puerarin self-emulsifying microemulsified composition and its preparation method
A composition and technology of puerarin, applied in the field of puerarin self-emulsifying microemulsion composition and its preparation, can solve the problems of poor puerarin solubility, increased cost, low bioavailability of puerarin tablets, etc., and achieve improved bioavailability , the effect of improving solubility
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[0019] Puerarin self-emulsifying microemulsion composition, it is the solution that comprises puerarin, oil phase, surfactant, co-surfactant, it is characterized in that described solution is the microemulsion that particle diameter is less than 100nm, and this microemulsion is at least Containing a hydrophilic surfactant of polyoxyethylene with HLB (Chinese) value greater than 10, the amount of surfactant is 15-60% of the weight of the microemulsion without water, preferably 25-50%, so The surfactant is selected from condensation products of sorbitan fatty acid esters, polyoxyethylene castor oil and polyoxyethylene hydrogenated castor oil; at least one oil phase with 15 to 25 carbon atoms in the carbon chain, The content of the oil phase is 2 to 15% of the total weight of the microemulsion, and the selected oil phase is selected from refined vegetable oil, peanut oil, ethyl oleate, ethyl linoleate, isopropyl myristate, tricaprylic caprylate Glyceride or triglyceride myristate...
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