Strontium ranelate chewing tablet and its preparation process

A technology of strontium ranelate and chewable tablets, which is applied in the directions of pill delivery, bone disease, and drug combination, etc., can solve problems such as inconvenience of patients, and achieve the effect of reducing packaging volume, easy to take, and controllable product quality.

Inactive Publication Date: 2006-10-04
CHONGQING PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the inconvenience brought by the existing strontium ranelate granule to patients who do not have the conditions for taking i

Method used

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  • Strontium ranelate chewing tablet and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0026] Example 1

[0027] prescription:

[0028] Strontium ranelate 1000g

[0029] Mannitol 500g

[0030] Aspartame 30g

[0031] 10% starch slurry appropriate amount

[0032] Orange flavor 50g

[0033] Magnesium stearate 15g

[0034] 1000 pieces

[0035] Weigh the raw and auxiliary materials of the above prescription and pass through a 100-mesh sieve respectively, and prepare the starch into 10% starch slurry for later use; mix strontium ranelate, mannitol, and aspartame evenly, and add an appropriate amount of 10% starch slurry to make a soft Material, pass a 20-mesh sieve to granulate, dry at 60~80℃, and then pass a 20-mesh sieve to granulate. The dry granules are mixed with sweet orange flavor and magnesium stearate, mixed evenly, and then compressed into capsule-shaped tablets.

Example Embodiment

[0036] Example 2

[0037] prescription:

[0038] Strontium ranelate 1000g

[0039] Lactose 500g

[0040] Glycyrrhizin 30g

[0041] Sodium cyclamate 15

[0042] 5% polyvinylpyrrolidone 50% ethanol solution

[0043] Apple flavor 50g

[0044] Talcum powder 20g

[0045] 1000 pieces

[0046] Weigh the raw and auxiliary materials of the above prescription and pass through a 100-mesh sieve, and prepare polyvinylpyrrolidone with 50% ethanol to prepare a 5% solution for later use; mix strontium ranelate, lactose, glycyrrhizin, and sodium cyclamate, and add A suitable amount of 5% polyvinylpyrrolidone in 50% ethanol is made into a soft material, which is granulated through a 20-mesh sieve, dried at 60-80°C, and then sized through a 20-mesh sieve. The dry granules are mixed with apple flavor and talcum powder, mixed evenly, and then pressed into oval tablets.

Example Embodiment

[0047] Example 3

[0048] prescription:

[0049] Strontium ranelate 1000g

[0050] Compressible starch 170g

[0051] Microcrystalline cellulose 100g

[0052] Xylitol 200g

[0053] Stevia 30g

[0054] Strawberry flavor 50g

[0055] Magnesium stearate 20g

[0056] Monascus pigment 30g

[0057] 1000 pieces

[0058] Weigh the raw and auxiliary materials of the above-mentioned prescription amount, respectively pass through a 100-mesh sieve, mix strontium ranelate, compressible starch, microcrystalline cellulose, xylitol, stevia, strawberry flavor, and then mix with magnesium stearate Mix it with monascus pigment and press directly into a heart-shaped tablet weighing about 1.6g.

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Abstract

The invention relates to a chewing tablet containing strontium ranelate as the active ingredient and its preparing process, wherein the tablet comprises 10-90% of strontium ranelate, 9-80% of bulking agent, 0.1-10% of flavoring agent, 0.1-10% of glidant or lubricant, and 0-20% of moistening agent or binding agent. The chewing tablet can be used for treating and preventing osteoporosis.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a chewable tablet containing strontium ranelate as an active ingredient and a preparation method thereof. Background technique [0002] Osteoporosis is a common and easily overlooked metabolic disease. Osteoporosis patients range from low back pain and limb weakness to hunched back and bone pain in severe cases. The direct harm is that the incidence of fractures is significantly increased. In particular, femoral neck fractures, vertebral fractures, and distal radius fractures that occur at the hip and wrist are known as the "three major fractures of osteoporosis." Because women's postmenopausal bone loss is significantly accelerated, women who have stopped menstruating for 15 to 20 years may lose 30% of their total body bone weight, so postmenopausal women are prone to postmenopausal osteoporosis. [0003] Strontium ranelate (strontium ranelate), chemical name: 3-thio...

Claims

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Application Information

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IPC IPC(8): A61K31/381A61K9/20A61P19/10
Inventor 赵小萍邓杰牟才华樊斌
Owner CHONGQING PHARMA RES INST
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