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Strontium ranelate chewing tablet and its preparation process

A technology of strontium ranelate and chewable tablets, which is applied in the directions of pill delivery, bone disease, and drug combination, etc., can solve problems such as inconvenience of patients, and achieve the effect of reducing packaging volume, easy to take, and controllable product quality.

Inactive Publication Date: 2006-10-04
CHONGQING PHARMA RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the inconvenience brought by the existing strontium ranelate granule to patients who do not have the conditions for taking it with boiled water, and to provide a ranelic acid with small volume, exquisite packaging, good taste, easy to carry and take. Strontium chewable tablet and preparation method thereof

Method used

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  • Strontium ranelate chewing tablet and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] prescription:

[0028] Strontium ranelate 1000g

[0029] Mannitol 500g

[0030] Aspartame 30g

[0031] 10% starch slurry appropriate amount

[0032] Sweet Orange Flavor 50g

[0033] Magnesium Stearate 15g

[0034] Made into 1000 pieces

[0035] Weigh the raw and auxiliary materials of the above prescription amount and pass through 100 mesh sieve respectively, prepare starch into 10% starch slurry for later use; mix strontium ranelate, mannitol, and aspartame evenly, add appropriate amount of 10% starch slurry to make soft Material, passed through a 20-mesh sieve to granulate, dried at 60-80°C, and then passed through a 20-mesh sieve for granulation. The dry granules are mixed with sweet orange essence and magnesium stearate, mixed evenly, and then compressed into capsule-shaped tablets.

Embodiment 2

[0037] prescription:

[0038] Strontium ranelate 1000g

[0039] Lactose 500g

[0040] Glycyrrhizin 30g

[0041] Sodium cyclamate 15

[0042] 5% polyvinylpyrrolidone 50% ethanol solution appropriate amount

[0043] Apple essence 50g

[0044] Talc powder 20g

[0045] Made into 1000 pieces

[0046] Weigh the raw and auxiliary materials of the above-mentioned prescription quantity and pass through 100 mesh sieve respectively, and prepare a 5% solution of polyvinylpyrrolidone with 50% ethanol for later use; mix strontium ranelate, lactose, glycyrrhizin, and sodium cyclamate evenly, and add An appropriate amount of 5% polyvinylpyrrolidone 50% ethanol solution is made into a soft material, passed through a 20-mesh sieve to granulate, dried at 60-80°C, and then passed through a 20-mesh sieve for granulation. The dry granules are mixed with apple essence and talcum powder, mixed evenly, and then pressed into oval tablets.

Embodiment 3

[0048] prescription:

[0049] Strontium ranelate 1000g

[0050] Compressible starch 170g

[0051] Microcrystalline Cellulose 100g

[0052] Xylitol 200g

[0053] Stevia 30g

[0054] Strawberry essence 50g

[0055] Magnesium Stearate 20g

[0056] Red Yeast Pigment 30g

[0057] Made into 1000 pieces

[0058] Weigh the raw and auxiliary materials of the above prescription amount, pass through a 100-mesh sieve, mix strontium ranelate, compressible starch, microcrystalline cellulose, xylitol, stevioside, and strawberry flavor evenly, and then mix them with magnesium stearate Mix evenly with Monascus pigment, and then directly press into heart-shaped tablets weighing about 1.6g.

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Abstract

The invention relates to a chewing tablet containing strontium ranelate as the active ingredient and its preparing process, wherein the tablet comprises 10-90% of strontium ranelate, 9-80% of bulking agent, 0.1-10% of flavoring agent, 0.1-10% of glidant or lubricant, and 0-20% of moistening agent or binding agent. The chewing tablet can be used for treating and preventing osteoporosis.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a chewable tablet containing strontium ranelate as an active ingredient and a preparation method thereof. Background technique [0002] Osteoporosis is a common and easily overlooked metabolic disease. Osteoporosis patients range from low back pain and limb weakness to hunched back and bone pain in severe cases. The direct harm is that the incidence of fractures is significantly increased. In particular, femoral neck fractures, vertebral fractures, and distal radius fractures that occur at the hip and wrist are known as the "three major fractures of osteoporosis." Because women's postmenopausal bone loss is significantly accelerated, women who have stopped menstruating for 15 to 20 years may lose 30% of their total body bone weight, so postmenopausal women are prone to postmenopausal osteoporosis. [0003] Strontium ranelate (strontium ranelate), chemical name: 3-thio...

Claims

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Application Information

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IPC IPC(8): A61K31/381A61K9/20A61P19/10
Inventor 赵小萍邓杰牟才华樊斌
Owner CHONGQING PHARMA RES INST
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