Vitamin A liposome artificial lacrimal eye drops

Abstract

The present invention relates to a vitamin A liposome artificial tears eye drops for preventing and curing xerophthalmia and ophthalmokopia. Its composition includes fat-soluble vitamin A, liposome encapsulating material, vitamin E and artificial tears hydrated liquor, in which the fat-soluble vitamin A is vitamin A palmitate or vitamin A acetate, the liposome encapsulating material is soya bean lecithin and cholesterol, and the composition of artificial tears hydrated liquor includes sodium hydrogen carbonate, sodium chloride, glucose, potassium chloride, calcium chloride and water. Besides, according to requirements one or several kinds of auxiliary components of menthanol, PVP and HPMC, etc. also can be added.

Description

Technical field: [0001] The invention relates to an eye drop, in particular to a liposome artificial tear eye drop containing vitamin A. For the prevention and treatment of dry eye disease and eye fatigue. Background technique: [0002] The causes of dry eye or dry conjunctiva and dry eye mainly include the following aspects: [0003] 1. Due to physiological reasons such as advanced age, lack of sleep, and mental stress, the quality of tears is reduced. [0004] 2. The effect of taking some antihypertensive drugs and some neuroleptics on tear production. At present, some contraceptives can reduce tear production. [0005] 4. Engaged in computer operation, car driving, reading and other fine work for a long time. [0006] 5. Due to other reasons such as contact lenses, allergic conjunctivitis, air pollution, ultraviolet rays, etc., the tears are reduced and the quality is reduced. [0007] 6. Patients with dry eye syndrome are sensitive to airflow, and the cornea is parti...

AI Technical Summary

Problems solved by technology

[0006] 5. Due to other reasons such as contact lenses, allergic conjunctivitis, air pollution, ultraviolet rays, etc., the tears are reduced and the quality is reduced

[0025] The administration of eye drops, due to the action of eyeball movement and the nasolacrimal system, causes a large amount of drug loss, which requires multiple administrations every day, the dosage is inaccurate, and the concentration of the drug in the eye fluctuates greatly; the administration of suspension or ointment also affects vision and eye movements

In order to overcome the above shortcomings, add hydrophilic gel carbomer (carbomer) to increase the viscosity, delay the residence time of the drug, and increase the absorption; but it is easy to blur the vision and affect the eyelid movement; or implant a long-acting controlled release drug delivery system , but the patient has a foreign body sensation