Vitamin A liposome artificial lacrimal eye drops

A technology of artificial tears and vitamins, applied in liposome delivery, active ingredients of hydroxyl compounds, organic active ingredients, etc., can solve problems affecting vision and eye movement, tear reduction, foreign body sensation in patients, etc.

Active Publication Date: 2006-10-25
CHINA RESOURCES SAIKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 5. Due to other reasons such as contact lenses, allergic conjunctivitis, air pollution, ultraviolet rays, etc., the tears are reduced and the quality is reduced
[0025] The administration of eye drops, due to the action of eyeball movement and the nasolacrimal system, causes a large amount of drug loss, which requires multiple administrations every day, the dosage is inaccurate, and the concentration of the drug in the eye fluctuates ...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] Prescription: 1000ml fat-soluble vitamin A liposome

[0083] Vitamin A palmitate or vitamin A acetate (calculated as vitamin A) 0.25g

[0084] Soy Lecithin 8.90g

[0085] Cholesterol 1.10g

[0086] Vitamin E 0.05g

[0087] 1000ml

[0088] Preparation of hydration solution: 1000ml

[0089] Sodium bicarbonate 0.20g

[0090] Sodium chloride 9.00g

[0091] Glucose 1.00g

[0092] Potassium chloride 0.14g

[0093] Calcium chloride 0.42g

[0094] 1000ml

[0095] pH value: 5.0~7.0

[0096] The preparation method is as follows:

[0097] 1. Weigh the prescribed amount of vitamin A palmitate or vitamin A acetate, soybean lecithin, cholesterol, vitamin E, and dissolve it with chloroform or absolute ethanol or ether or petroleum ether.

[0098] 2. Put the lipid solution on a thin film evaporator, and remove the organic solvent under reduced pressure to obtain a lipid film.

[0099] 3. Prepare the hydration solution acc...

Embodiment 2

[0103] Prescription: 1000ml fat-soluble vitamin A liposome

[0104] Vitamin A palmitate or vitamin A acetate (calculated as vitamin A) 0.5g

[0105] Soy Lecithin 8.25g

[0106] Cholesterol 1.75g

[0107] Vitamin E 0.05g

[0108] 1000ml

[0109] Preparation of hydration solution: 1000ml

[0110] Sodium bicarbonate 0.20g

[0111] Sodium chloride 9.00g

[0112] Glucose 1.00g

[0113] Potassium chloride 0.14g

[0114] Calcium chloride 0.42g

[0115] Menthol 10mg

[0116] PVP 20mg

[0117] 1000ml

[0118] pH value: 5.0~7.0

[0119] The preparation method is the same as in Example 1.

Embodiment 3

[0121] Prescription: 1000ml fat-soluble vitamin A liposome

[0122] Vitamin A palmitate or vitamin A acetate (calculated as vitamin A) 1.0g

[0123] Soy Lecithin 7.52g

[0124] Cholesterol 2.48g

[0125] Vitamin E 0.05g

[0126] 1000ml

[0127] Preparation of hydration solution: 1000ml

[0128] Sodium bicarbonate 0.20g

[0129] Sodium chloride 9.00g

[0130] Glucose 1.00g

[0131] Potassium chloride 0.14g

[0132] Calcium chloride 0.42g

[0133] HPMC 250mg

[0134] 1000ml

[0135] pH value: 5.0~7.0

[0136] The preparation method is the same as in Example 1.

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PUM

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Abstract

The present invention relates to a vitamin A liposome artificial tears eye drops for preventing and curing xerophthalmia and ophthalmokopia. Its composition includes fat-soluble vitamin A, liposome encapsulating material, vitamin E and artificial tears hydrated liquor, in which the fat-soluble vitamin A is vitamin A palmitate or vitamin A acetate, the liposome encapsulating material is soya bean lecithin and cholesterol, and the composition of artificial tears hydrated liquor includes sodium hydrogen carbonate, sodium chloride, glucose, potassium chloride, calcium chloride and water. Besides, according to requirements one or several kinds of auxiliary components of menthanol, PVP and HPMC, etc. also can be added.

Description

Technical field: [0001] The invention relates to an eye drop, in particular to a liposome artificial tear eye drop containing vitamin A. For the prevention and treatment of dry eye disease and eye fatigue. Background technique: [0002] The causes of dry eye or dry conjunctiva and dry eye mainly include the following aspects: [0003] 1. Due to physiological reasons such as advanced age, lack of sleep, and mental stress, the quality of tears is reduced. [0004] 2. The effect of taking some antihypertensive drugs and some neuroleptics on tear production. At present, some contraceptives can reduce tear production. [0005] 4. Engaged in computer operation, car driving, reading and other fine work for a long time. [0006] 5. Due to other reasons such as contact lenses, allergic conjunctivitis, air pollution, ultraviolet rays, etc., the tears are reduced and the quality is reduced. [0007] 6. Patients with dry eye syndrome are sensitive to airflow, and the cornea is parti...

Claims

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Application Information

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IPC IPC(8): A61K9/127A61K31/07A61K31/355A61P27/02
Inventor 孙猛孙仁俊
Owner CHINA RESOURCES SAIKE PHARMA
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