Beta-element nitrogenous derivative, and its preparing method and use

Abstract

This invention discloses beta-elemene nitrogen contained derivant. Nitrogen contain hetero atomic ring is brought in beta-elemene nitrogen structure to synthesize new structure beta-elemene nitrogen contained derivant. Its molecular structure formula is (I), R represents C1-C20 fatty amine group and aromatic amine group, C1-C20 contains hetero atomic ring amido group, cyclohexane backbone has three chirality centers. The derivent has some biological activities like alkaloid, it can increase polar at the same time, and make the synthesized derivent display certain alkalinity, so the goal of improve water-solubility by it with mineral acid or organic acid salt.

Description

Technical field:

[0001] The present invention relates to new β-elemene nitrogen-containing derivatives and a preparation method thereof, to an intermediate for synthesizing said β-elemene nitrogen-containing derivatives and a preparation method thereof, and to said β-elemene nitrogen-containing derivatives Application of nitrogen derivatives. Background technique:

[0002] The β-elemene (I) isolated from the volatile oil of Curcuma wenyujin Y.H.Chen et C.Ling (Curcuma wenyujin Y.H.Chen et C.Ling), also known as Wenzezhu, is a broad-spectrum anti-tumor drug elemene milk developed by my country. The main components of (Guo Yongming, Wu Xiuying, Chen Yuren. Isolation and identification of elemene in the volatile oil of Wen Zezhu [J]. Chinese Medicine Bulletin, 1983, 8(30): 31-33). β-Elemene has high selectivity to tumor cells, no myelosuppressive effect, no obvious liver and kidney toxicity, and has the "double effect" of selectively inhibiting tumor cell proliferation and impr...

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