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Separation and refining method of 1,3-methyl glycol in ferment liquor

A technology of propylene glycol and fermentation broth, applied in the fields of bioengineering and chemical engineering, can solve problems such as blockage of pipelines, and achieve the effects of no blockage problem, reduction of separation cost, and short process route.

Active Publication Date: 2006-12-20
PETROCHINA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for separating and refining 1,3-propanediol from microbial fermentation liquid. By selecting suitable reagents, the crystalline sediment in the fermentation liquid can be effectively separated, and the foaming and condensation of the still liquid in the later stage of rectification can be overcome. Block and clogged pipelines, achieve continuous operation, reduce separation costs as much as possible, and increase the recovery rate of 1,3-propanediol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The fermented liquid used in the embodiment of the present invention is obtained by adopting Klebsiella pneumoniae (Klebsiella pneumoniae) to produce 1,3-propanediol by batch-feeding glycerin fermentation, and each cubic meter of this fermented liquid contains 1,3-propanediol 70kg.

[0023] Klebsiella (K.pneumoniae) was purchased from the China General Microorganism Culture Collection (CGMCC), strain number: 1.1736.

[0024] The separation and refining process is as follows:

[0025] (1) Get 4000g of sterilized fermented liquid, add 1600g of normal-temperature n-amyl alcohol to it, carry out batch rectification to it under reduced pressure to remove moisture content therein, batch rectification tower (referred to as dehydration tower) ) The operating pressure is 0.05MPa, and the reflux ratio is 1:1. When the amount of distillate reached 3200g, the rectification was stopped.

[0026] (2) When the still liquid that step (1) obtains is separated the sediment of 365g by ...

Embodiment 2

[0031] (1) Get 4000g of sterilized fermented liquid, add 1600g of normal-temperature n-butanol to it, carry out intermittent rectification to it under reduced pressure to remove moisture content wherein, operating condition is the same as embodiment 1, when tower top When no water distilled out, the rectification stopped, and the amount of distillate at the top of the tower was 4100g.

[0032] (2) The still liquid that step (1) obtains is separated the sediment of 580g (filter residue is more viscous) by vacuum suction filtration, obtains the clear liquid of 830g. The filter cake was washed with 160 g of n-butanol.

[0033](3) Add 100g of glycerol to the pretreatment solution obtained in step (2), and stir to make it fully mixed, then add this mixed solution to the dehydration tower still, and the operating conditions are the same as in Example 1. Dealcoholization was stopped when the fraction containing n-butanol reached 710 g.

[0034] (4) adding the still liquid of the de...

Embodiment 3

[0037] The n-amyl alcohol in embodiment 1 is changed into n-hexanol, and other operating conditions and steps are with embodiment 1, and obtained result is identical with embodiment 1.

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Abstract

This invention relates to a method for separating and purifying 1,3-dihydroxypropane from microbial fermentation liquor, comprising: after the sterilization and dehydration of fermentation liquor, add in 1-pentanol or isoamyl alcohol, n-butanol and n-hexanol, then remove the sediment in the fermentation liquor by filtration or settlement followed by washing; add in appropriate amount of glycerol or 1,4-butylene glycol to the supernatant to recover 1-pentanol or isoamyl alcohol, n-butanol and n-hexanol, by decompression or normal pressure distillation, so as to produce high-purity 1,3-dihydroxypropane, with more than 95% recovering rate. This invention is characterized of simple separation process, mature technique, low separation cost, and little additional introduced agent with easy recovery. Besides, the crystallization sediment in the fermentation liquor can be efficiently separated, which overcomes the problems of foaming, agglomerating and pipe clogging during distillation, so as to realize continuous operation.

Description

technical field [0001] The invention belongs to the technical fields of bioengineering and chemical engineering, and relates to the separation technology of microbial fermentation liquid, in particular to a method for separating and refining 1,3-propanediol from microbial fermentation liquid. Background technique [0002] 1,3-Propanediol (1,3-Propanediol, referred to as 1,3-PD) is an important chemical raw material, mainly used in the synthesis of new polyester materials polytrimethylene terephthalate (PTT), polyurethane and engineering thermoplastics Plastics, etc. These new polymers have many excellent properties, such as good elasticity, dimensional stability and dyeability, anti-ultraviolet, ozone and nitrogen oxide coloring properties, internal stress resistance, low water adsorption, low static electricity and good Biodegradability, excellent rigidity, toughness and insulation, etc., so it has broad application prospects in textile, carpe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C31/20C07C29/80C12P7/18
Inventor 张鹏刘海军马玉喜
Owner PETROCHINA CO LTD
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