Method for preparing D-pan-ethyl ether by microbial enzyme method

A microbial enzyme and diethyl ether technology, which is applied in the field of microbial enzymatic preparation of D-panethyl ether, can solve the problems of many operation steps, large amount of wastewater treatment, high price of resolving agent, etc., and achieve the effect of simple process and low manufacturing cost

Active Publication Date: 2007-01-24
重庆鑫富化工有限公司
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Problems solved by technology

Disadvantages of splitting DL-pantolactone by chemical method are high price of splitting agent, many operation steps, troublesome product refining, the product may contain impurities such as chemicals and solvents that are harmf

Method used

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Embodiment Construction

[0015] The culture of microorganisms is carried out by fermentation and culture according to the conventional filamentous fungus culture method. Prepare the enzyme-producing medium as 2% glycerol, 1% peptone, 0.5% yeast extract, 0.2% corn steep liquor, pH 6.5, divide into 100mL / 500mL triangular bottles, heat sterilize in a sterilizing pot for 20 minutes, The temperature was 121°C. The strains Fusarium moniliforme AS3.349; Fusarium oxysporum AF93327; Fusarium bisporum F.dimerum AS 3.1831; .fujikuroi AS3.4663 and other strains were inoculated into the culture medium and cultured in shake flasks at 28°C for 5 days. After the cultivation, the bacteria were collected by filtration. Prepare a 10% DL-pantolactone solution containing 0.05mol / L CaCl2 and a pH of 7.0, add 4g of wet bacteria to 100ml DL-pantoolactone solution for hydrolysis reaction, control the temperature at 30°C and the stirring speed 200r / min, automatic feeding of ammonia water to adjust pH 7.0, hydrolysis rate an...

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Abstract

The microbial enzyme process of preparing D-pan-ethyl ether includes the following steps: splitting chemically synthesized DL- pantoic lactone to obtain D-pantoic lactone with filamentous fungi of Fusarium, Gibberella, Aspergillus, Penicillium, Rhizopus, Gliocladium, Aureobasidium, etc; and the subsequent reaction of D-pantoic lactone with 3-ethoxy propylamine to prepare D-pan-ethyl ether with high optical activity and high purity. The present invention has low preparation cost, simple technological process, high splitting efficiency and no environmental pollution.

Description

technical field [0001] The invention relates to a method for preparing D-panthenethyl ether by microbial enzymatic method. Background technique [0002] D-pantothenic acid is an ether compound of D-pantothenic acid. D-pantothenic acid is an indispensable substance for organisms. It belongs to the water-soluble B vitamins and is a component of coenzyme A. It exists in all living tissues and participates in sugar, Physiological processes such as fat and protein metabolism. Because D-pantothenic acid is extremely unstable, its commercial form mostly adopts calcium D-pantothenate or D-panthenol, but calcium D-pantothenate is in solid form, and its application range is limited; although D-panthenol is widely used in medicine and daily chemical industry However, it is inconvenient for some applications due to its high viscosity and poor thermal stability; while D-panthenethyl ether has similar functions and effects as D-panthenol, and is easily absorbed t...

Claims

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Application Information

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IPC IPC(8): C12P13/02C12R1/66C12R1/77C12R1/80C12R1/845C12R1/645
Inventor 白彦兵孙志浩林关羽何本雄姜伟林
Owner 重庆鑫富化工有限公司
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