Novel imaging agents comprising caspase-3 inhibitors

A cysteine ​​aspartic acid, protease technology, applied in the directions of in vivo radioactive preparations, antiviral agents, preparations for in vivo experiments, etc.
CN1905904AInactive Publication Date: 2007-01-31GE HEALTHCARE LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GE HEALTHCARE LTD
Publication Date
2007-01-31
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to diagnostic imaging agents for in vivo imaging. Such imaging agents comprise synthetic caspase 3 inhibitors labeled with an imaging moiety suitable for in vivo diagnostic imaging. The invention also provides a pharmaceutical composition and a radiopharmaceutical composition comprising the imaging agent, and a kit for preparing the radiopharmaceutical composition. The present invention also provides chelator conjugates of caspase 3 inhibitors which are suitable for use in the preparation of imaging agents comprising radioactive or paramagnetic metal ions. Imaging agents of the invention are useful in vivo for diagnostic imaging and / or therapeutic monitoring in various disease states involving caspase 3.
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Description

field of invention

[0001] The present invention relates to diagnostic imaging agents for in vivo imaging. Such imaging agents comprise synthetic caspase-3 inhibitors labeled with an imaging moiety suitable for in vivo diagnostic imaging. Background of the invention

[0002] Programmed cell death (apoptosis) is a complex process involving many cellular processes involving multilevel regulation. Apoptosis is initiated by one of two pathways. The first is an extrinsic pathway initiated by cell surface death receptors, and the second is an intrinsic pathway initiated by endogenous initiators such as DNA damage induced by UV radiation. These two pathways culminate in energy-demanding co-ordinated cell death, which, unlike necrotic cell death, does not involve an inflammatory response. Apoptotic cells send out "eat me" signals on their cell surface, which induce other cells to destroy them through phagocytosis.

[0003] Apoptosis is essential for many processes in the body. F...

Claims

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