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Lacrimal duct plug and its preparing process and use

A technology of embolism and lacrimal duct, which is applied in the field of lacrimal duct embolism and its preparation, can solve problems such as high price, foreign body sensation, and inappropriate eye structure characteristics, and achieve the effect of improving biocompatibility and facilitating clinical operation

Inactive Publication Date: 2007-02-07
SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to clinical trials, because Chinese people have smaller palpebral fissures, tighter upper and lower eyelids, or eyelids that are closer to the eyeball, it is possible to make the top cover and the ball of the eye by using the cap-type or trumpet-type tear duct plugs from Medennium or CIBA Vision in the United States. Conjunctival friction, causing foreign body sensation, not suitable for Chinese eye structure characteristics, and expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, the preparation of collagen-based lacrimal duct plug

[0027] The degree of deacetylation is 80%, the viscosity average molecular weight is 2×10 5 The chitosan was dissolved in 0.01% hydrochloric acid solution to prepare a solution with a chitosan concentration of 2%. Collagen (prepared according to the method of steps 1-8 in Example 1 of Patent No. 01142070.7) was dissolved in 0.01% hydrochloric acid solution to obtain a solution with a collagen concentration of 2%. The above-mentioned chitosan solution and collagen solution are uniformly mixed according to the chitosan and collagen protein mass ratio of 1:9. Extruded or injected into a rod-shaped body, introduced into a closed container of alkali vapor formed by 0.2mol / L sodium carbonate solution, exposed for 30 minutes, and then exposed to formaldehyde gas for 25 minutes. The obtained collagen-based lacrimal duct plug is sealed in paper-plastic packaging, 60 Co radiation sterilization serves as the f...

Embodiment 2

[0031] Embodiment 2, the preparation of collagen-based lacrimal duct plug

[0032] The degree of deacetylation is 80%, the viscosity average molecular weight is 2×10 5 Chitosan was dissolved in 1% hydrochloric acid solution to prepare a solution with a chitosan concentration of 4%. Collagen (purchased from Guangzhou Hechuan Biotechnology Co., Ltd.) was dissolved in 1% hydrochloric acid solution to obtain a solution with a collagen concentration of 4%. The above-mentioned chitosan solution and collagen solution are uniformly mixed according to the chitosan and collagen protein mass ratio of 1:4. Extruded or injected into rods, introduced into a closed container of alkali vapor formed by 0.2mol / L sodium carbonate solution, exposed for 30 minutes, and then exposed to the mixed gas of formaldehyde and glyoxal (the volume ratio of formaldehyde and glyoxal is 1: 1) for 25 minutes. The obtained collagen-based lacrimal duct plug is sealed in paper-plastic packaging, 60 Co radiatio...

Embodiment 3

[0036] Embodiment 3, the preparation of collagen-based lacrimal duct plug

[0037] The degree of deacetylation is 80%, the viscosity average molecular weight is 2×10 5 The chitosan was dissolved in 0.001% hydrochloric acid solution to prepare a solution with a chitosan concentration of 1%. Collagen (purchased from Canada Bioengineering Development Corporation) was dissolved in 0.001% hydrochloric acid solution to obtain a solution with a collagen concentration of 1%. The above-mentioned chitosan solution and collagen solution are uniformly mixed according to the chitosan and collagen protein mass ratio of 1:99. Extruded or injected into a rod-shaped body, introduced into a closed container of alkali vapor formed by 0.2mol / L sodium carbonate solution, exposed for 30 minutes, and then exposed to formaldehyde gas for 25 minutes. The obtained collagen-based lacrimal duct plug is sealed in paper-plastic packaging, 60Co radiation sterilization Serve final product collagen-based l...

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Abstract

The invention relates to a dacryosolen plug, relative preparation and application, wherein it materials are the collagen at 60-100 deals and one or two of following components as chitose at 1-20 deals and polyvinyl alcohol at 1-20 deals; the inventive product can function the lacrimal passage for 10-50 day, while the water adsorption force can reach 10mg / mg and the volume expanding rate can be over 10mm3 / mm3; when it has been planted for 10mins, it will adsorb water, to radial expand into flexible cylinder, to block the lacrimal passage.

Description

technical field [0001] The invention relates to a lacrimal duct embolism, a preparation method and application thereof. Background technique [0002] Many eye diseases are related to the amount of tears secreted by the surface of the eye. These ophthalmic conditions include dry eye, corneal ulcers, conjunctivitis, blepharitis, and many other conditions external to the eye. Dry eye syndrome is the most common ophthalmic disease caused by lack of tears in clinical practice. In mild cases, it manifests as dry eyes, red eyes, burning sensation, foreign body sensation or eye soreness, and in severe cases, diffuse epithelial punctate or flake staining of the cornea occurs. , will cause eye pain and blindness in the long run. The normality of tears and tear film on the surface of the eyes depends on the comprehensive balance of tear secretion, tear evaporation, tear discharge, and tear composition and layer integrity. [0003] The treatment of dry eye syndrome mainly relies on a...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/14
Inventor 武继民李志宏关静许媛媛
Owner SANITARY EQUIP INST ACAD OF MILITARY MEDICAL SCI PLA
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