Lacrimal duct plug and its preparing process and use
A technology of embolism and lacrimal duct, which is applied in the field of lacrimal duct embolism and its preparation, can solve problems such as high price, foreign body sensation, and inappropriate eye structure characteristics, and achieve the effect of improving biocompatibility and facilitating clinical operation
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[0026] Example 1. Preparation of collagen-based lacrimal duct embolism
[0027] The degree of deacetylation is 80%, and the viscosity average molecular weight is 2×10 5 The chitosan is dissolved in a 0.01% hydrochloric acid solution to prepare a solution with a chitosan concentration of 2%. Collagen (prepared according to the method of steps 1-8 in Example 1 of the patent No. 01142070.7) was dissolved in a 0.01% hydrochloric acid solution to obtain a solution with a collagen concentration of 2%. The above-mentioned chitosan solution and collagen solution are mixed uniformly according to the mass ratio of chitosan and collagen at a ratio of 1:9. Extruded or injected into a rod-shaped body, introduced into a closed container of alkali vapor formed by 0.2mol / L sodium carbonate solution and exposed for 30 minutes, and then exposed to formaldehyde gas for 25 minutes. The obtained collagen-based punctal plug is packaged in a paper-plastic airtight package, 60 Co radiation sterilization ...
Example Embodiment
[0031] Example 2. Preparation of collagen-based lacrimal duct embolism
[0032] The degree of deacetylation is 80%, and the viscosity average molecular weight is 2×10 5 The chitosan was dissolved in a 1% hydrochloric acid solution to prepare a solution with a 4% chitosan concentration. The collagen (purchased from Guangzhou Hechuan Biotechnology Co., Ltd.) was dissolved in a 1% hydrochloric acid solution to obtain a solution with a collagen concentration of 4%. The above-mentioned chitosan solution and collagen solution are mixed uniformly according to the mass ratio of chitosan and collagen of 1:4. Extrude or inject into a rod-shaped body, introduce it into a closed container of alkali vapor formed by a 0.2mol / L sodium carbonate solution and expose for 30 minutes, and then expose it to a mixed gas of formaldehyde and glyoxal (the volume ratio of formaldehyde and glyoxal is 1: 1) Medium exposure for 25 minutes. The obtained collagen-based punctal plug is packaged in a paper-plasti...
Example Embodiment
[0036] Example 3. Preparation of collagen-based lacrimal duct embolism
[0037] The degree of deacetylation is 80%, and the viscosity average molecular weight is 2×10 5 The chitosan is dissolved in a 0.001% hydrochloric acid solution to prepare a solution with a chitosan concentration of 1%. The collagen (purchased from the Canadian Bioengineering Development Company) was dissolved in a 0.001% hydrochloric acid solution to obtain a solution with a collagen concentration of 1%. The above-mentioned chitosan solution and collagen solution are mixed uniformly according to the mass ratio of chitosan and collagen at a ratio of 1:99. Extrude or inject into a rod-shaped body, introduce it into a closed container of alkali vapor formed by a 0.2mol / L sodium carbonate solution and expose it for 30 minutes, and then expose it to formaldehyde gas for 25 minutes. The obtained collagen-based punctal plug is packaged in a paper-plastic airtight package, 60Co radiation sterilization is the final p...
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