Implantation micro-electrode having integrated medicinal agent releasing function, its manufacturing method and application

Abstract

An implantation microelectrode with medicine releasing function is composed of a functional region consisting of a metallic site for electric stimulation and electric record and a micropool for releasing medicine, a welded point, and a connection line between said functional region and welded point and wrapped by substrate and an insulating layer. Said micropool has at least one opening covered by a nano-hole film and sealed by biodegradable polymer, and an acid-sensitive gel micropost in it, which is expanding when it is in contact with body fluid to extrude the medicine out of said micropool.

Description

technical field [0001] The invention relates to an implanted microelectrode integrated with drug release function, which belongs to the fields of neurorehabilitation and neurobiology. Background technique [0002] Neural engineering system is currently a very active and rapidly developing research field, such as brain-computer interface, neural prosthesis and other issues have received more and more attention. Microelectrodes have become an important tool for revealing the working mechanism of the nervous system, treating neurological diseases and neurorehabilitation. Whether it is a brain-computer interface or a neural prosthesis, electrodes are usually implanted in animals or patients, and electrical signals are loaded through the electrodes to stimulate or inhibit neural activity to achieve functional electrical stimulation (FES), or use micro Electrodes convert neural activity into electrical signals that are recorded for analysis and study. According to different obje...

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Problems solved by technology

However, no matter what kind of microelectrode is implanted in the body, it will cause more or less damage to the nerve tissue, which may lead to implantation failure or microelectrode work failure after a period of time [J.N.Turner, et al. "Cerebralastrocyte response to micromachined silicon implants,” Exp. Neurol., 1999, 156: 33-49.]

On the one hand, this kind of implantation failure or failure may be due to the implanted microelectrode damages its peripheral nerve cells, leading to their death and degeneration, which makes the implanted microelectrode lose the object of stimulation or recording, thereby leading to implantation failure; on the other hand, even if After the microelectrode is implanted, the surrounding nerve cells are not completely damaged, but because of the rejection reaction of the body after the microelectrode implantation, a layer of sheath-like fibrous layer tissue will be formed around the long-term implanted microelectrode, which will affect the stimulation of the microelectrode. Or recording effect, resulting in the long-term work stability of the microelectrode being affected

Therefore, due to the lack of a long-term effective and reliable microelectrode working system, it is difficult to make breakthroughs in the research of brain-computer interface and neural prosthesis.

[0003] A large number of basic studies have shown that nerve growth factors or neurotrophic factors play a very important role in the survival, development, growth, differentiation, injury repair, and nerve regeneration of neurons. In addition, studies have also shown that anti-fibrosis factors or anti-inflammatory agents It can effectively prevent the formation of sheath-like fibrous tissue around damaged cells, but these research results have not been paid attention to and applied in the study of implantable electrodes

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