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Preparation of gardenia jasminoides by membrane separation technology

A gardenia extract, membrane separation technology, applied in the direction of membrane technology, semipermeable membrane separation, carboxylate preparation, etc., can solve the problems of difficult storage, easy moisture absorption of products, etc., to reduce production costs, improve separation and purification efficiency, The effect of increasing the saturated adsorption capacity

Inactive Publication Date: 2010-05-19
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The Gardenia jasminoides extract prepared with a hydrophilic solvent contains main medicinal active ingredients such as gardenia iridoid glycosides, carotenoids or organic acids, but also contains a large amount of proteins, polysaccharides, tannins, etc. There are impurities, and the product has defects such as easy moisture absorption and difficult storage

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Take the gardenia produced in Fujian as the raw material, wash the fresh gardenia with water, dry (air-dried, dried or sun-dried), crush, and sieve through 20-30 mesh to obtain the gardenia powder, and put 2.9kg of the gardenia powder into the extraction tank In, using 10 times dry weight (W / W) of gardenia powder (W / W) of 40% methanol-acetone (1:1) aqueous solution, reflux and extract 3 times at 68°C for 2 hours each time, combine the extracts, filter, The filtrate is under the conditions of -0.06~-0.095MPa and 50~80°C, the solvent is recovered under reduced pressure, and it is concentrated in vacuo to form a gardenia extract. After testing, the extraction rates of gardenia iridoid glycosides, carotenoids and chlorogenic acid were 93.2%, 96.3% and 93.1%, respectively.

[0035] Then, the crude gardenia extract was mixed with appropriate amount of water to form a suspension to make the specific gravity of the suspension reach 1.03, and then a polysulfone membrane with a mole...

Embodiment 2

[0037] Put 2.6 kg of 20-30 mesh gardenia powder into the extraction tank, use 15 times the dry weight (W / W) of the gardenia powder in 25% methanol aqueous solution, extract twice at 50℃, 3 hours each time, and combine The extract is filtered, and the filtrate is recovered under reduced pressure under the conditions of -0.06~-0.095MPa and 50~80°C to recover the solvent and concentrate in vacuo to form a gardenia extract. After testing, the extraction rates of gardenia iridoid glycosides, carotenoids and chlorogenic acid were 92.3%, 92.8% and 91.8%, respectively.

[0038] Stir the crude gardenia extract with appropriate amount of water to form a suspension to make the specific gravity of the suspension reach 1.12, and then use a polyvinylidene fluoride membrane with a molecular weight cut-off of 30,000 to carry out membrane separation and impurity removal at 0.60 MPa to remove protein, polysaccharides and other After the macromolecular impurities, the gardenia extract after membran...

Embodiment 3

[0040] Put 2.7 kg of 20-30 mesh gardenia powder into the extraction tank, use 5 times the dry weight (W / W) of the gardenia powder in 75% methanol aqueous solution, reflux for 1 hour at 80°C, filter, and filter the filtrate in- Under the conditions of 0.06~-0.095MPa and 50~80℃, the solvent was recovered under reduced pressure and concentrated in vacuo to form a gardenia extract. After determination, the extraction rates of gardenia iridoid glycosides, carotenoids and chlorogenic acid were 95.6%, 95.0% and 93.5%, respectively.

[0041] Stir the crude gardenia extract with appropriate amount of water to form a suspension to make the specific gravity of the suspension reach 1.03, and then use an inorganic ceramic membrane with a membrane pore size of 0.22μm to separate and remove impurities at 0.25MPa to remove protein and polysaccharides and other large molecules After impurities, the gardenia extract after membrane separation and purification is obtained. After determination, the ...

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Abstract

A process for preparing the extract from capejasmine fruit by use of membrane separation technique includes such steps as extracting in hydrophilic solvent to obtain coarse extract, adding water to become suspension, and membrane separation for removing protein, polyose and other macromolecular impurities.

Description

Technical field [0001] The invention relates to a green chemical preparation method for extracting and separating medicinal active ingredients from plants, and more specifically to a method for preparing gardenia extracts by adopting membrane separation technology. Background technique [0002] Gardenia is the fruit of Gardenia, an evergreen shrub of Rubiaceae (Rubiaceae) of the genus Gardenia. It is a large traditional Chinese medicinal material in China. It is listed in the first batch of Chinese medicinal materials for medicine and food by the Ministry of Health. It is a national protected species of Chinese medicine. The main medicinal ingredients of Ling injection, Longdan Xiegan tablets and Yindan Pinggan capsules are the first choice for the clinical treatment of jaundice hepatitis in traditional Chinese medicine and the raw material for extracting gardenia natural pigments. They are abundant in Fujian, Zhejiang, Jiangxi, Hui, Mountainous areas in Hunan and other provinces...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/744C07B63/00C07C403/24C07C51/47C07C67/56B01D71/02B01D71/08B01D71/34B01D71/56
Inventor 陈剑锋郭养浩陈浩
Owner FUZHOU UNIV
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