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Chinese traditional western compound medicine and its preparation method

A compound prescription and drug technology, applied in the field of medicine, to achieve the effects of inhibiting tumor growth, improving tumor-bearing survival rate and quality of life, and reducing the efficacy of chemotherapy

Inactive Publication Date: 2007-05-02
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, the use of ginseng or its extracts, Poria cocos or its extracts, Gynostemma pentaphyllum or its extracts, and matrine to make compatible prescriptions to prepare anti-tumor drugs has not been reported.

Method used

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  • Chinese traditional western compound medicine and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0173] Example 1 Preparation and content determination of ginseng total saponin

[0174] Preparation of total ginsenosides

[0175] Take ginseng, crush it, add 10 times the amount of ethanol for reflux extraction twice, each time for 3 hours, combine the extracts, refrigerate, filter, the filtrate recovers the ethanol and concentrates to a thick paste, add water to an appropriate amount (each 1ml is equivalent to 1g of the original medicinal material ), stir well, refrigerate, and filter. The filtrate is added to the processed macroporous resin column, first eluted with 2 to 3 times the column volume of water, discarded the washing liquid, and then used 3 times the column volume Elute with 80% ethanol, collect the eluate, recover the ethanol and concentrate it under reduced pressure to a thick paste with a relative density of 1.30 to 1.35, and vacuum dry to obtain.

[0176] Three batches of total ginseng saponins were prepared respectively, and the yields are shown in Table 2-1.

...

Embodiment 2

[0192] Example 2 Preparation and content determination of ginseng sugar

[0193] Preparation of Ginseng Polysaccharide

[0194] Take ginseng, chop it, extract with 75% ethanol, reflux for 4 hours, filter, dry the medicine residue, add water and cook five times, combine the decoction, add 0.3% activated carbon, stir for 30 minutes, let stand overnight, filter Pass the filtrate through a resin column, collect the effluent, concentrate under reduced pressure, add ethanol to make the alcohol content reach 95%, refrigerate, filter, take the precipitate and wash with acetone, drain the acetone, take out the precipitate and dry it at 60-80°C, crush it Get the powder.

[0195] Three batches of ginseng polysaccharide were prepared separately, and the yields are shown in Table 2-2.

[0196] Identification of Ginseng Polysaccharide

[0197] (1) Take about 0.2g of ginseng polysaccharide, add 5ml of water to dissolve it, add 5 drops of alkaline copper tartrate test solution, heat it to produce...

Embodiment 3

[0206] Example 3 Preparation and content determination of Poria cocos extract

[0207] Preparation of Poria cocos extract

[0208] Take Poria cocos, pulverize it into fine powder, add 0.5mol / L sodium hydroxide solution to extract twice, stir, first time 4 hours, add 8 times the amount of solvent, second time 3 hours, add 6 times the amount of solvent, stir at low temperature, Filter with suction, combine the filtrate, neutralize with 10% acetic acid, refrigerate for 12 hours, and filter. Wash the precipitate with water, acetone, and ether successively, and dry to obtain it.

[0209] Three batches of Poria extracts were prepared, and the yields are shown in Table 2-3.

[0210] Identification of Poria cocos extract

[0211] (1) Take 1g of Poria cocos extract powder, add 10ml of acetone, heat to reflux for 10 minutes, filter, evaporate the filtrate to dryness, add 1ml of glacial acetic acid to the residue to dissolve, add 1 drop of sulfuric acid, it will appear light red, then turn b...

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Abstract

A compound medicine in the form of injection or orally taken solid or liquid for preventing and treating cancer is proportionally prepared from ginseng, tuckahoe, gynostemma pentaphyllum and sophocarpidine. Its preparing process is also disclosed.

Description

1. Technical field [0001] The present invention relates to a Chinese and Western compound medicine made from ginseng or its extract, Poria or its extract, Gynostemma pentaphyllum or its extract, matrine, and a preparation method thereof, application in the preparation of anti-tumor medicines and preparations containing the compound medicine Preparation belongs to the field of medical technology. 2. Background technology [0002] Tumor is a serious disease threatening human life and health, and the mortality rate of patients is extremely high. With the deteriorating human living environment, the incidence of cancer is increasing year by year. The treatment of cancer in modern medicine is mainly surgery combined with radiotherapy and chemotherapy. Although surgery can remove the primary lesions, it cannot fundamentally prevent the regeneration and reproduction of cancer cells. Although radiotherapy and chemotherapy can kill cancer cells, they also damage a large number of normal ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/424A61P35/00A61K31/4375
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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