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Method of controlling size of nanometer gold grain with phospholipid

A technology of gold nanoparticles and phospholipids, applied in the nano field, can solve the problems of inability to realize the biocompatibility of gold nanoparticles and lack of biological activity, and achieve the effects of simple synthesis method, good controllability and simple process

Inactive Publication Date: 2007-06-06
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the chemical stabilizer that controls the growth of gold nanoparticles does not have biological activity and cannot achieve the biocompatibility of size-controllable gold nanoparticles.

Method used

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  • Method of controlling size of nanometer gold grain with phospholipid
  • Method of controlling size of nanometer gold grain with phospholipid
  • Method of controlling size of nanometer gold grain with phospholipid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Using auric acid as the initial raw material, the reduction of sodium borohydride produces small-sized gold nanoparticles, which are prepared into a seed solution, and then mixed with the growth solution mixed with auric acid and phospholipids according to different ratios to prepare phospholipid-assisted The size-controllable gold nanoparticles.

[0026] Step a: In a 100 ml round bottom flask, add 2 mg of auric acid, 1.5 mg of citrate and 20 ml of deionized water, stir well, and prepare 2.5×10 -4 mol / L of the solution, while adding 0.6 ml of an aqueous solution of 2.3 mg of sodium borohydride newly prepared in an ice bath dropwise, along with the addition of sodium borohydride, the solution turns pink, marking a diameter of 1.5 nanometers For the generation of gold particles, the citrate in the solution acts as a stabilizer for the gold nanoparticles, and the prepared seed solution can be stabilized for 2 to 5 hours.

[0027] Step b: In a 100-ml round-bottomed flask, ...

Embodiment 2

[0032] Using auric acid as the initial raw material, the reduction of sodium borohydride produces small-sized gold nanoparticles, which are prepared into a seed solution, and then mixed with the growth solution mixed with auric acid and phospholipids according to different ratios to prepare phospholipid-assisted The size-controllable gold nanoparticles.

[0033] Step a: Add 1 mg of auric acid, 1 mg of citrate and 10 ml of deionized water in a 100 ml round bottom flask, stir well, and prepare 2.5×10 -4 mol / L solution, while adding 0.1 ml of an aqueous solution newly prepared in an ice bath to dissolve 1 mg of sodium borohydride dropwise, with the addition of sodium borohydride, the solution turns pink, marking the diameter of 1.5 nanometers For the generation of gold particles, the citrate in the solution acts as a stabilizer for the gold nanoparticles, and the prepared seed solution can be stabilized for 2 to 5 hours.

[0034] Step b: Add 1 mg of chloric acid aureus and 50 ml...

Embodiment 3

[0039] Using auric acid as the initial raw material, the reduction of sodium borohydride produces small-sized gold nanoparticles, which are prepared into a seed solution, and then mixed with the growth solution mixed with auric acid and phospholipids according to different ratios to prepare phospholipid-assisted The size-controllable gold nanoparticles.

[0040] Step a: in 100 milliliters of round-bottomed flasks, add 100 milligrams of auric acid, 100 milligrams of citrate and 20 milliliters of deionized water, fully stir, be mixed with the solution of 0.0125 mol / liter, add dropwise at the same time In the ice bath, 1 milliliter of aqueous solution of 100 mg of sodium borohydride was newly prepared. With the addition of sodium borohydride, the solution turned pink, indicating the generation of gold particles with a diameter of 1.5 nanometers. The citrate in the solution As a stabilizer of gold nanoparticles, the prepared seed solution can be stabilized for 2 to 5 hours.

[00...

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Abstract

The present invention relates to nanometer technology, and is especially method of controlling size of nanometer gold grain with phospholipid. Chloroauric acid is reduced with sodium borohydride to obtain nanometer gold grain of 1.5 nm diameter, while citrate is added for stabilizing to obtain seed liquid. Chloroauric acid and phospholipid are then mixed to compound growing liquid. By means of altering the compounding ratio between the seed liquid and the growing liquid, nanometer gold grain of different sizes up to 30 nm may be obtained. The prepared nanometer gold grain of controllable size may be used in preparing biosensor, molecular detection device, biological catalysis device and other devices.

Description

technical field [0001] The invention relates to a method in the field of nanotechnology, in particular to a method for controlling the size of gold nanoparticles by using phospholipids. Background technique [0002] In the past ten years, a large number of research works have deeply explored the formation and morphological structure of gold nanoparticles. The preparation of gold nanoparticles has size controllability, which has potential application prospects in future biomedicine and molecular biology. People have been able to control the formation and morphology of gold nanostructures by changing experimental conditions and reaction systems. The formation of gold nanostructures and the size and shape of nanoparticles are determined by many factors, among which the choice of stabilizer plays an important role. For example, gold nanoparticles can form small-scale structures with a diameter of 5 nm in an aqueous system, and with the help of cationic surfactants, large-scale...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24
Inventor 何鹏朱新远
Owner SHANGHAI JIAO TONG UNIV