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Angelica polysaccharide iron and its preparing process

A polysaccharide iron, angelica technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, extracellular fluid diseases, etc., can solve the problems of skin pigmentation, unsatisfactory treatment effect, cytotoxicity and biological system damage.

Inactive Publication Date: 2007-07-11
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ferrous sulfate has higher iron content and better absorption, it can alleviate the symptoms of iron deficiency and anemia to a certain extent, but studies have shown that this iron supplement has many side effects: stimulate the gastrointestinal tract, cause nausea, vomiting, diarrhea, Cause gastric discomfort, constipation and other gastrointestinal adverse reactions; when administered intravenously, it can cause allergic reactions, local pain and skin pigmentation
Moreover, studies have confirmed that ferrous ions can catalyze the generation of OH free radicals in the body, causing cytotoxicity and damage to biological systems
Facts have proved that the widely used ferrous sulfate or other ferrous salts in the prior art are not ideal for the treatment of iron deficiency anemia.

Method used

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  • Angelica polysaccharide iron and its preparing process
  • Angelica polysaccharide iron and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] Weigh 2g of angelica polysaccharide, 0.5g of trisodium citrate, dissolve in 60ml of distilled water, heat in a water bath at about 70°C and stir continuously. During the stirring process, first add 20% sodium hydroxide solution drop by drop to adjust the pH value to 8~ 9. Then slowly add 2mol / L ferric chloride solution dropwise; repeat the above operation of adding sodium hydroxide solution dropwise and ferric chloride solution dropwise until reddish-brown insoluble substances appear in the reaction solution; continue at 70°C Heat and stir in a water bath for about 1 hour. After stopping stirring, centrifuge to remove the precipitate, collect the reddish-brown centrifugate, add about twice the amount of absolute ethanol to the centrifugate, and keep stirring at the same time; after standing overnight, pour off the supernatant, The precipitate was washed with anhydrous methanol, 95% ethanol, absolute ethanol, and ether, and then the precipitate was vacuum-dried to obtain ...

Embodiment 2

[0061] Weigh 250g of angelica sinensis, soak in 2000ml water for 2 hours, heat and decoct for 1 hour, filter while it is hot; repeat the extraction once, and combine the filtrate obtained twice to obtain the water extract of angelica polysaccharide; add 10% calcium hydroxide solution dropwise to adjust The pH value of the polysaccharide water extract is to pH>10; after standing overnight, filter the non-alkali-soluble impurities with gauze to obtain the polysaccharide alkali extract; add 3mol / L sulfuric acid solution to adjust the alkali extract to pH 5-6; Filtrate, concentrate the filtrate to about 200ml, then add about twice the amount of absolute ethanol while stirring constantly; after standing overnight, pour off the supernatant, wave off the residual ethanol, and dry the precipitate in vacuum to obtain dark brown angelica polysaccharide about 15g.

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Abstract

The invention discloses a chiretta ferric polysaccharide, which comprises the following steps: adopting high-quantivalent ferric compound blood tonic to provide raw material; extracting anoelica sinensis polysaccharide from anoelica sinensis through boiling in the water; dripping iron trichloride solution in the anoelica sinensis polysaccharide solution; displaying the adsorbing peak and corresponding chemical group irradiated by infrared spectrum: -OH and -NH extension vibration near 3400cm-1, -C-H extension vibration near 2930cm-1, -C-O vibration of amide carbonyl near 1620cm-1, -C-O vibration of carboxyl near 1400cm-1, C-O-H and C-O-C vibration near 1050 cm-1, adsorbing peak at 855cm-1 and 680cm-1.

Description

technical field [0001] The invention relates to a medical drug and a preparation method thereof, in particular to a polysaccharide-iron complex for treating anemia and a preparation method thereof. Background technique [0002] Angelica sinensis (Oliv.) Diels] is a commonly used traditional Chinese medicine, which has the functions of nourishing blood, promoting blood circulation, regulating menstruation and relieving pain. These functions have been confirmed by research. Basic research shows that angelica also has anti-colic, anti-asthma, analgesic, anti-rheumatic and other functions. These functions depend on pharmacologically active components such as coumarin, phytosterols, polysaccharides, and flavonoids contained in Angelica sinensis. A large number of pharmacological studies have shown that angelica can be used as a blood-tonifying drug, and its effect of nourishing blood and promoting blood circulation is mainly due to the fact that the polysaccharides in angelica ...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P7/06
Inventor 王凯平
Owner HUAZHONG UNIV OF SCI & TECH
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