Soluble recombinant botulinum toxin proteins
Patent Information
- Authority / Receiving Office
- US · United States
- Current Assignee / Owner
- ALLERGAN SALES ALLERGAN BOTOX
- Publication Date
- 2005-10-27
- Estimated Expiration
- Not applicable · inactive patent
Smart Images
Figure 1 
Figure 2 
Figure 3
Abstract
Description
[0001] This application is a Continuation-In-Part of copending application Ser. No. 08 / 405,496, filed Mar. 16, 1995.FIELD OF THE INVENTION
[0002] The present invention relates to the isolation of polypeptides derived from Clostridium botulinum neurotoxins and the use thereof as immunogens for the production of vaccines, including multivalent vaccines, and antitoxins. BACKGROUND OF THE INVENTION
[0003] The genus Clostridium is comprised of gram-positive, anaerobic, spore-forming bacilli. The natural habitat of these organisms is the environment and the intestinal tracts of humans and other animals. Indeed, clostridia are ubiquitous; they are commonly found in soil, dust, sewage, marine sediments, decaying vegetation, and mud. [See e.g., P. H. A. Sneath et al., “Clostridium,” Bergey's Manual® of Systematic Bacteriology, Vol. 2, pp. 1141-1200, Williams & Wilkins (1986).] Despite the identification of approximately 100 species of Clostridium, only a small number have been recognized as ...